Abstract: This invention relates to a transdermal patch in the form of a layer complex, comprising a backing layer, a drug-reservoir layer comprising pharmacologically active ingredients and pharmaceutically acceptable adjuvants, and a release liner covering the drug-reservoir layer, characterized in that the drug-reservoir layer comprises isosorbide dinitrate and Bisoprolol at a ratio of 1:3 to 3:1 by weight, as the pharmacologically active ingredients. Animal tests show that said patch can reduce the elevation of T wave of cardiogram, the increase of the level of myocardial enzyme in blood serum, and the extension of the range of myocardial infarction caused by ligating the coronary artery in animals. Results show that said patch exhibits a considerable synergistic effect in the treatment of cardiovascular diseases and has good preventive and therapeutic effects on several adverse events on heart.
Type:
Grant
Filed:
December 9, 2005
Date of Patent:
December 6, 2011
Assignee:
Beijing Kangbeide Pharmaceutical Technology Development Co., Ltd.
Inventors:
Shuming Wang, Li Wang, Xiaoling Fan, Huiyong Xue, Shuang Zhang, Enhong Zhang, Xuying Zhong, Yucheng Lu, Chun Li, Li Song
Abstract: This invention relates to a transdermal patch in the form of a layer complex, comprising a backing layer, a drug-reservoir layer comprising pharmacologically active ingredients and pharmaceutically acceptable adjuvants, and a release liner covering the drug-reservoir layer, characterized in that the drug-reservoir layer comprises isosorbide dinitrate and Bisoprolol at a ratio of 1:3 to 3:1 by weight, as the pharmacologically active ingredients. Animal tests show that said patch can reduce the elevation of T wave of cardiogram, the increase of the level of myocardial enzyme in blood serum, and the extension of the range of myocardial infarction caused by ligating the coronary artery in animals. Results show that said patch exhibits a considerable synergistic effect in the treatment of cardiovascular diseases and has good preventive and therapeutic effects on several adverse events on heart.
Type:
Application
Filed:
December 9, 2005
Publication date:
November 27, 2008
Applicant:
BEIJING KANGBEIDE PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD
Inventors:
Shuming Wang, Li Wang, Xiaoling Fan, Huiyong Xue, Shuang Zhang, Enhong Zhang, Xuying Zhong, Yucheng Lu, Chun Li, Li Song