Abstract: A method and a system of calibrating a DC offset voltage on a resistor load are provided. The system may include a first operational amplifier, a second operational amplifier, a comparator, a digital signal processor, and a digital to analog convertor. At a calibration mode, under control of the digital signal processor, the system may utilize open-loop high gain characteristics of the first operational amplifier and the comparator to automatically detect and calibrate the DC offset voltage. At an operation mode, the system may automatically compensate the DC offset voltage based on the calibration of the DC offset voltage. In this way, the system and the method can automatically detect, calibrate, and compensate the DC offset voltage with reduced cost and technical complexity.