Patents Assigned to Bell Biosystems, Inc.
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Patent number: 10280403Abstract: The present invention is directed generally to eukaryotic host cells comprising artificial endosymbionts and methods of introducing artificial endosymbionts into eukaryotic host cells. The invention provides artificial endosymbionts that introduce a phenotype to host cells that is maintained in daughter cells. The invention additionally provides eukaryotic host cells containing magnetotactic bacteria.Type: GrantFiled: July 12, 2018Date of Patent: May 7, 2019Assignee: Bell Biosystems, Inc.Inventors: Caleb B. Bell, III, Alexey Bazarov
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Publication number: 20190112581Abstract: The present invention is directed generally to host cells with artificial endosymbionts, wherein the artificial endosymbiont and the host cell communicate with each other to alter a phenotype of the host cell. In some embodiments, the communication comprises the secretion of a polypeptide from the artificial endosymbiont into the host cell. The secreted polypeptide can be a selectable marker, a reporter protein, a transcription factor, a signal pathway protein, a receptor, a growth factor, a cytokine, an effector molecule or other factors that can produce a phenotype in the host cell.Type: ApplicationFiled: December 19, 2018Publication date: April 18, 2019Applicant: BELL BIOSYSTEMS, INC.Inventors: Caleb B. Bell, III, Alexey Bazarov, Abdul Wakeel, Joyce Barrozo
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Patent number: 10184114Abstract: The present invention is directed generally to host cells with artificial endosymbionts, wherein the artificial endosymbiont and the host cell communicate with each other to alter a phenotype of the host cell. In some embodiments, the communication comprises the secretion of a polypeptide from the artificial endosymbiont into the host cell. The secreted polypeptide can be a selectable marker, a reporter protein, a transcription factor, a signal pathway protein, a receptor, a growth factor, a cytokine, an effector molecule or other factors that can produce a phenotype in the host cell.Type: GrantFiled: September 1, 2017Date of Patent: January 22, 2019Assignee: Bell Biosystems, Inc.Inventors: Caleb B. Bell, III, Alexey Bazarov, Abdul Wakeel, Joyce Barrozo
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Publication number: 20180327721Abstract: The present invention is directed generally to eukaryotic host cells comprising artificial endosymbionts and methods of introducing artificial endosymbionts into eukaryotic host cells. The invention provides artificial endosymbionts that introduce a phenotype to host cells that is maintained in daughter cells. The invention additionally provides eukaryotic host cells containing magnetotactic bacteria.Type: ApplicationFiled: July 12, 2018Publication date: November 15, 2018Applicant: Bell Biosystems, Inc.Inventors: Caleb B. Bell, III, Alexey Bazarov
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Patent number: 10076579Abstract: The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell through at least five cell divisions, and methods of introducing such single-celled organisms into eukaryotic cells. The invention also provides methods of using such eukaryotic cells. The invention further provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetotactic bacteria.Type: GrantFiled: November 22, 2017Date of Patent: September 18, 2018Assignee: Bell Biosystems, Inc.Inventors: Caleb B. Bell, III, Alexey Bazarov
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Patent number: 10023843Abstract: The present invention is directed generally to eukaryotic host cells comprising artificial endosymbionts and methods of introducing artificial endosymbionts into eukaryotic host cells. The invention provides artificial endosymbionts that introduce a phenotype to host cells that is maintained in daughter cells. The invention additionally provides eukaryotic host cells containing magnetotactic bacteria.Type: GrantFiled: May 13, 2017Date of Patent: July 17, 2018Assignee: Bell Biosystems, Inc.Inventors: Caleb B. Bell, III, Alexey Bazarov
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Publication number: 20180092994Abstract: The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell through at least five cell divisions, and methods of introducing such single-celled organisms into eukaryotic cells. The invention also provides methods of using such eukaryotic cells. The invention further provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetotactic bacteria.Type: ApplicationFiled: November 22, 2017Publication date: April 5, 2018Applicant: Bell Biosystems, Inc.Inventors: Caleb B. Bell, III, Alexey Bazarov
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Publication number: 20180008728Abstract: The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell, and methods of introducing such single-celled organisms into eukaryotic cells. The invention provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetic bacteria. The invention further provides eukaryotic cells engineered with single-celled organisms to allow for multimodal observation of the eukaryotic cells. Each imaging method (or modality) allows the visualization of different aspects of anatomy and physiology, and combining these allows the imager to learn more about the subject being imaged.Type: ApplicationFiled: September 20, 2017Publication date: January 11, 2018Applicant: Bell Biosystems, Inc.Inventors: Caleb B. Bell, III, Alexey Bazarov
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Publication number: 20170362576Abstract: The present invention is directed generally to host cells with artificial endosymbionts, wherein the artificial endosymbiont and the host cell communicate with each other to alter a phenotype of the host cell. In some embodiments, the communication comprises the secretion of a polypeptide from the artificial endosymbiont into the host cell. The secreted polypeptide can be a selectable marker, a reporter protein, a transcription factor, a signal pathway protein, a receptor, a growth factor, a cytokine, an effector molecule or other factors that can produce a phenotype in the host cell.Type: ApplicationFiled: September 1, 2017Publication date: December 21, 2017Applicant: BELL BIOSYSTEMS, INC.Inventors: Caleb B. Bell, III, Alexey Bazarov, Abdul Wakeel, Joyce Barrozo
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Patent number: 9827333Abstract: The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell through at least five cell divisions, and methods of introducing such single-celled organisms into eukaryotic cells. The invention also provides methods of using such eukaryotic cells. The invention further provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetotactic bacteria.Type: GrantFiled: December 5, 2016Date of Patent: November 28, 2017Assignee: Bell Biosystems, Inc.Inventors: Caleb B. Bell, III, Alexey Bazarov
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Publication number: 20170335291Abstract: The present invention is directed generally to systems for making host cells with artificial endosymbionts. In an embodiment, the systems of the invention comprise a host cell, an artificial endosymbiont, a means for introducing the artificial endosymbiont to the host cell, a means for separating the host cells with artificial endosymbionts from free artificial endosymbionts, and a means for detecting artificial endosymbionts in host cells.Type: ApplicationFiled: August 10, 2017Publication date: November 23, 2017Applicant: BELL BIOSYSTEMS, INC.Inventors: Caleb B. Bell, III, Alexey Bazarov, Brad Rice
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Patent number: 9814790Abstract: The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell, and methods of introducing such single-celled organisms into eukaryotic cells. The invention provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetic bacteria. The invention further provides eukaryotic cells engineered with single-celled organisms to allow for multimodal observation of the eukaryotic cells. Each imaging method (or modality) allows the visualization of different aspects of anatomy and physiology, and combining these allows the imager to learn more about the subject being imaged.Type: GrantFiled: May 13, 2017Date of Patent: November 14, 2017Assignee: Bell Biosystems, Inc.Inventors: Caleb B. Bell, III, Alexey Bazarov
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Patent number: 9752129Abstract: The present invention is directed generally to host cells with artificial endosymbionts, wherein the artificial endosymbiont and the host cell communicate with each other to alter a phenotype of the host cell. In some embodiments, the communication comprises the secretion of a polypeptide from the artificial endosymbiont into the host cell. The secreted polypeptide can be a selectable marker, a reporter protein, a transcription factor, a signal pathway protein, a receptor, a growth factor, a cytokine, an effector molecule or other factors that can produce a phenotype in the host cell.Type: GrantFiled: October 22, 2016Date of Patent: September 5, 2017Assignee: Bell Biosystems, Inc.Inventors: Caleb B. Bell, III, Alexey Bazarov, Abdul Wakeel, Joyce Barrozo
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Publication number: 20170247663Abstract: The present invention is directed generally to eukaryotic host cells comprising artificial endosymbionts and methods of introducing artificial endosymbionts into eukaryotic host cells. The invention provides artificial endosymbionts that introduce a phenotype to host cells that is maintained in daughter cells. The invention additionally provides eukaryotic host cells containing magnetotactic bacteria.Type: ApplicationFiled: May 13, 2017Publication date: August 31, 2017Applicant: Bell Biosystems, Inc.Inventors: Caleb B. Bell, III, Alexey Bazarov
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Publication number: 20170246325Abstract: The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell, and methods of introducing such single-celled organisms into eukaryotic cells. The invention provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetic bacteria. The invention further provides eukaryotic cells engineered with single-celled organisms to allow for multimodal observation of the eukaryotic cells. Each imaging method (or modality) allows the visualization of different aspects of anatomy and physiology, and combining these allows the imager to learn more about the subject being imaged.Type: ApplicationFiled: May 13, 2017Publication date: August 31, 2017Applicant: Bell Biosystems, Inc.Inventors: Caleb B. Bell, III, Alexey Bazarov
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Publication number: 20170239375Abstract: The present invention relates generally to the field of endosymbiosis, eukaryotic cells engineered with artificial endosymbionts, and magnetotactic bacteria. In particular, the invention provides single-celled organisms such as artificial endosymbionts, including magnetotactic bacteria, eukaryotic cells to host those single-celled organisms, and methods of using eukaryotic cells containing single-celled organisms. The invention also provides eukaryotic cells engineered with intracellular single-celled organisms which eukaryotic cells can be tracked in an animal and monitored for viability. The invention also provides for multimodal detection of a eukaryotic cell in an animal to monitor the location and viability of the eukaryotic cell.Type: ApplicationFiled: February 23, 2017Publication date: August 24, 2017Applicant: Bell Biosystems, Inc.Inventor: Caleb B. BELL, III
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Patent number: 9657275Abstract: The present invention is directed generally to eukaryotic host cells comprising artificial endosymbionts and methods of introducing artificial endosymbionts into eukaryotic host cells. The invention provides artificial endosymbionts that introduce a phenotype to host cells that is maintained in daughter cells. The invention additionally provides eukaryotic host cells containing magnetotactic bacteria.Type: GrantFiled: September 12, 2016Date of Patent: May 23, 2017Assignee: Bell Biosystems, Inc.Inventors: Caleb Bell, III, Alexey Bazarov
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Patent number: 9657358Abstract: The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell, and methods of introducing such single-celled organisms into eukaryotic cells. The invention provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetic bacteria. The invention further provides eukaryotic cells engineered with single-celled organisms to allow for multimodal observation of the eukaryotic cells. Each imaging method (or modality) allows the visualization of different aspects of anatomy and physiology, and combining these allows the imager to learn more about the subject being imaged.Type: GrantFiled: September 12, 2016Date of Patent: May 23, 2017Assignee: Bell Biosystems, Inc.Inventors: Caleb B. Bell, III, Alexey Bazarov
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Publication number: 20170080109Abstract: The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell through at least five cell divisions, and methods of introducing such single-celled organisms into eukaryotic cells. The invention also provides methods of using such eukaryotic cells. The invention further provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetotactic bacteria.Type: ApplicationFiled: December 5, 2016Publication date: March 23, 2017Applicant: Bell Biosystems, Inc.Inventors: Caleb B. BELL, III, Alexey Bazarov
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Publication number: 20160376561Abstract: The present invention is directed generally to eukaryotic host cells comprising artificial endosymbionts and methods of introducing artificial endosymbionts into eukaryotic host cells. The invention provides artificial endosymbionts that introduce a phenotype to host cells that is maintained in daughter cells. The invention additionally provides eukaryotic host cells containing magnetotactic bacteria.Type: ApplicationFiled: September 12, 2016Publication date: December 29, 2016Applicant: Bell Biosystems, Inc.Inventors: Caleb Bell, III, Alexey Bazarov