Abstract: The invention provides a modified haem which is chemically coupled with a polyalkylene glycol methyl ether or an .omega.-amino derivative thereof through at least one of the two carboxyl groups in said haem molecule. The modified haem has a peroxidase activity and is soluble in water or various organic solvents.
Abstract: Disclosed is a conjugate comprising a magnetic material and a physiologically active substance bound to each other through a polyethylene glycol derivative, and a conjugate comprising a magnetic material and a polyethylene glycol derivative bound to each other. According to the present invention, a bioreactor enabling application to or recovery of physiologically active substances under liquid state by utilizing the magnetic properties is provided.
Abstract: A modified lipase, comprising lipase molecules which are partially substituted with an active derivative of a polyalkylene glcyol having a hydrophobic group at the terminal end.
Abstract: A method of treating thrombosis, which comprises administering to a living body a thrombosis preventive and curative preparation containing as an active ingredient a pharmaceutically effective amount of a plant sterol selected from the group consisting of sitosterol and fucosterol, or an ester thereof.