Patents Assigned to Ben-Gurion University of the Negev Research and Development Authority
  • INSULIN-LIKE GENE OF PRAWNS AND USES THEREOF
    Publication number: 20110010784
    Abstract: Nucleic acid molecules encoding an insulin-like factor of the androgenic gland of the freshwater prawn Macrobrachium rosenbergii (M. rosenbergii) are disclosed. Also disclosed are methods of silencing the expression of the insulin-like factor gene in decapod crustaceans order, particularly in M. rosenbergii, useful for producing male monosex populations.
    Type: Application
    Filed: February 4, 2009
    Publication date: January 13, 2011
    Applicant: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Amir Sagi, Tomer Ventura
  • Cells containing a nanopatch sensor in their membrane
    Patent number: 7855073
    Abstract: The present invention provides isolated cells comprising nanopatch sensors integrated into the cell membrane thereof, wherein said sensors are provided in the form of perturbation-sensitive constructs, and wherein said perturbation-sensitive constructs respond to perturbations of the cell membrane by means of a detectable change in one or more physical or chemical properties associated with said construct.
    Type: Grant
    Filed: September 28, 2004
    Date of Patent: December 21, 2010
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventor: Raz Jelinek
  • Fragments of NKp44 and NKp46 for targeting viral-infected and tumor cells
    Patent number: 7825085
    Abstract: The present invention relates generally to peptides derived from the natural cytotoxicity receptors on natural killer (NK) cells and to antibodies against peptide epitopes on these receptors. In particular, the present invention identifies an essential epitope in the proximal domain of NKp46 and NKp44 receptors present on NK cells, as a crucial element for the binding to viral-infected cells. The present invention provides peptides that are derived from the amino acid sequence of NKp46 receptor, capable of specific targeting of viral-infected cells and tumor cells and monoclonal antibodies which recognize a specific domain of NKp46. The present invention further provides hyperglycosylated peptides that are derived from the NKp44 receptor, capable of specific targeting of viral-infected cells.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: November 2, 2010
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Ofer Mandelboim, Angel Porgador
  • NANOWIRES, METHOD OF FABRICATION THE SAME AND USES THEREOF
    Publication number: 20100272993
    Abstract: A method of forming a nanowire structure is disclosed. The method comprises applying on a surface of carrier liquid a layer of a liquid composition which comprises a surfactant and a plurality of nanostructures each having a core and a shell, and heating at least one of the carrier liquid and the liquid composition to a temperature selected such that the nanostructures are segregated from the surfactant and assemble into a nanowire structure on the surface.
    Type: Application
    Filed: April 8, 2010
    Publication date: October 28, 2010
    Applicant: Ben Gurion University of the Negev Research and Development Authority
    Inventors: Roman VOLINSKY, Raz Jelinek
  • TELOMERASE ACTIVATING COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20100267667
    Abstract: The present invention is directed to use of a series of compounds and compositions comprising the same for activating telomerase and treating diseases, disorders and/or conditions related thereto.
    Type: Application
    Filed: June 4, 2008
    Publication date: October 21, 2010
    Applicant: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Aviv Gazit, Shimon Slavin, Esther Priel, Sara Yitzchak
  • Method for the preparation of dispersions of carbon nanotubes
    Patent number: 7812083
    Abstract: The invention provides a method for the preparation of a suspension of de-agglomerated carbon nanotubes, comprising mixing agglomerated carbon nanotubes with a block copolymer. Further, a powder of de-agglomerated carbon nanotubes is provided, that can be easily redispersed to obtain a suspension of untangled carbon nanotubes. The invention also relates to the use of the provided materials in the preparation of composites, and in electronics.
    Type: Grant
    Filed: December 13, 2004
    Date of Patent: October 12, 2010
    Assignee: Ben Gurion University of the Negev Research and Development Authority
    Inventor: Rachel Yerushalmi-Rozen
  • Alginate Biomaterials for the Treatment of Hepatic Disorders
    Publication number: 20100247652
    Abstract: The present invention relates to methods for the treatment of hepatic disorders in a subject in need thereof. More specifically, the methods of the invention are based on the administration, preferably, systemic administration, of a therapeutically effective amount of at least one biocompatible alginate biomaterial, any modification thereof and any combination thereof. The invention further provides methods for sustaining serum albumin levels, and/or reducing serum AST and ALT, in subjects suffering from hepatic disorder. Still further, the invention provides methods for reducing apoptosis and inducing cell proliferation in a damaged liver tissue of a subject suffering of hepatic disorder, using the alginate biomaterial described by the invention.
    Type: Application
    Filed: November 27, 2008
    Publication date: September 30, 2010
    Applicants: HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD., BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Yaron Ilan, Gadi Lalazar, Eyal Shteyer, Ami Ben-Yaakov, Smadar Cohen, Tsiona Elkayam
  • Polydiacetylene-containing solid colorimetric and/or fluorescent detector, method for its preparation and uses thereof
    Patent number: 7794968
    Abstract: The invention provides a colorimetric and/or fluorescent detector, which is a solid organic matrix, most preferably in the form of a gel, comprising polydiacetylene(s) and one or more lipids. Processes for preparing the detector and methods for using the same, including for the detection of microorganism suspected to be present in food products, are also provided.
    Type: Grant
    Filed: January 9, 2006
    Date of Patent: September 14, 2010
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventor: Raz Jelinek
  • INJECTABLE CROSS-LINKED POLYMERIC PREPARATIONS AND USES THEREOF
    Publication number: 20100190741
    Abstract: A therapeutic composition for treatment of a body tissue which includes an aqueous solution of a cross-linked polymer being capable of: (i) maintaining a liquid state in storage at room temperature for at least 24 hours; and (ii) assuming a gel state following deposition within the body tissue. The therapeutic composition can be effectively administered into a damaged body tissue via injection or catheterization, thereby treating the damaged body tissue.
    Type: Application
    Filed: December 24, 2009
    Publication date: July 29, 2010
    Applicant: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Smadar Cohen, Jonathan Leor
  • INJECTABLE CROSS-LINKED POLYMERIC PREPARATIONS AND USES THEREOF
    Publication number: 20100173867
    Abstract: A therapeutic composition for treatment of a body tissue which includes an aqueous solution of a cross-linked polymer being capable of: (i) maintaining a liquid state in storage at room temperature for at least 24 hours; and (ii) assuming a gel state following deposition within the body tissue. The therapeutic composition can be effectively administered into a damaged body tissue via injection or catheterization, thereby treating the damaged body tissue.
    Type: Application
    Filed: December 24, 2009
    Publication date: July 8, 2010
    Applicant: Ben-Gurion University of the Negev Research and Development Authority.
    Inventors: Smadar Cohen, Jonathan Leor
  • Highly conductive ordered ion exchange membranes
    Patent number: 7740967
    Abstract: Process for producing ion exchange membranes. A matrix material that comprises a polymeric component chosen from the group consisting of monomeric and oligomeric polymer precursors and cross-linkable polymers is provided. Ion cation or anion exchange particles, or proton or hydroxyl or ion conducting particles, or cation or anion exchange polymers, or proton or hydroxyl or ion conducting polymers are introduced in the matrix. The particles are mixed or the polymer is dissolved with the matrix. The resulting mixture is formed into membrane configuration. The particles or the domains of the polymer formed by polymer-matrix phase separation upon solvent evaporation or cooling, are ordered by an electric field.
    Type: Grant
    Filed: July 3, 2003
    Date of Patent: June 22, 2010
    Assignee: Ben Gurion University of the Negev Research and Development Authority
    Inventors: Yoram Oren, Viatcheslav Freger, Ora Kedem, Charles Linder, Eliyahu Korin
  • MICRO-CONCENTRATORS FOR SOLAR CELLS
    Publication number: 20100147375
    Abstract: A solar cell system comprises a solar cell comprising a grid and a photo-sensitive area, wherein the grid includes a conductor, and an optical micro-structure positioned between the conductors, wherein the micro-structure covers at least a portion of the conductors.
    Type: Application
    Filed: February 18, 2008
    Publication date: June 17, 2010
    Applicants: Ben Gurion University of the Negev Research and Development Authority, Naftali P. Eisenberg
    Inventors: Omer Korech, Jeffrey Gordon, Ivgeny Katz, Daniel Feuermann, Naftali P. Eisenberg
  • Hydrogel functionalized with a polymerizable moiety and their uses as biosensors or bioreactors
    Patent number: 7737240
    Abstract: The present invention relates to a new hydrogel functionalized with a polymerizable moiety, the polymerized hydrogels, films and gels comprising the same and their use for cells, proteins, DNA or other molecules encapsulation, including use as biosensors or bioreactors.
    Type: Grant
    Filed: March 3, 2008
    Date of Patent: June 15, 2010
    Assignees: Universite Joseph Fourier-Grenoble 1, Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Robert Marks, Serge Cosnier, Boris Polyak, Elena Rodica Ionescu, Khalil Abu-Rabeah
  • SULFUR CHELATED RUTHENIUM COMPOUNDS USEFUL AS OLEFIN METATHESIS CATALYSTS
    Publication number: 20100113722
    Abstract: Sulfur chelated ruthenium compounds represented by the following formula: wherein M indicates the ruthenium metal bound to a benzylidene carbon; R represents C1-C7 alkyl group or optionally substituted aryl; X1 and X2 each independently represent halogen; Y1 and Y2 each independently denote unsubstituted or alkyl-substituted phenyl; and Z independently represents hydrogen, electron withdrawing or electron donating substituent, with m being an integer from 1 to 4, and processes and compositions related thereto.
    Type: Application
    Filed: October 30, 2009
    Publication date: May 6, 2010
    Applicant: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: N. Gabriel LEMCOFF, Amos BEN-ASULY
  • Thulium-containing low dose rate brachytherapy seed
    Publication number: 20100099940
    Abstract: A low dose rate brachytherapy seed having activity in the range between 0.5 and 10 millicurie, preferably less than 3 millicurie, comprising thulium-170 placed within a casing and at least one layer of a radiation emission modifying metal, said layer being provided either internally within the casing or on the outer surface thereof. The radiation emission modifying metal is preferably gold.
    Type: Application
    Filed: September 10, 2009
    Publication date: April 22, 2010
    Applicant: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Gad Shani, Amal Ayoub
  • COMPOSITION COMPRISING CRUSTACEAN GASTROLITH COMPONENTS AND ITS USE
    Publication number: 20100098774
    Abstract: Provided is a formulation containing amorphous or microcrystalline calcium carbonate finely interspersed with organic matter in a ratio of 10 parts of the carbonate per 1 to 3 parts of the organic matter, wherein the organic matter consists of chitin and polypeptide. The formulation is efficient in treating various pathological conditions, including proliferative diseases, neurological disorders, and musculoskeletal disorders.
    Type: Application
    Filed: October 7, 2007
    Publication date: April 22, 2010
    Applicants: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Yossi Ben, Amir Sagi
  • CARBON NANOTUBE REINFORCED POLYMER AND PROCESS FOR PREPARING THE SAME
    Publication number: 20100072432
    Abstract: Carbon nanotube reinforced polymers include a polymer and carbon nanotubes reinforcing the polymer. The carbon nanotube reinforced polymer exhibits a conductivity percolation threshold of less than 106 ?/cm at a carbon nanotube content of 1.5 wt. % and less. The polymer may be selected from a polyamide or a polystyrene based polymer. In certain embodiments, the carbon nanotube content is between 0.1 to 1.5 wt. %, and the reinforced polymer will have a percolation threshold at a carbon nanotube content of less than 0.5 wt. %.
    Type: Application
    Filed: May 6, 2009
    Publication date: March 25, 2010
    Applicants: STICHTING DUTCH POLYMER INSTITUTE, BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Cornelis E. KONING, Oren REGEV, Joachim LOOS
  • Process for improving membranes
    Patent number: 7677398
    Abstract: The invention provides a process for improving the antifouling properties and for increasing the selectivity of commercial composite polyamide nanofiltration (NF) and reverse osmosis (RO) membranes comprising circulating a low concentration of water soluble monomers and an initiating redox couple in an aqueous solvent, without transverse pressure over the surface of the membrane thereby effecting a free-radical graft polymerization on the surface of the membrane.
    Type: Grant
    Filed: September 4, 2005
    Date of Patent: March 16, 2010
    Assignee: Ben Gurion University of the Negev Research and Development Authority
    Inventors: Sophia Belfer, Rosalia Fainstein, Luba Kesselman, Charles Linder
  • Nitrogen extraction from organic wastes for fertigation in organic agriculture
    Patent number: 7674311
    Abstract: A method is provided for manufacturing a liquid nitrogen fertilizer from organic wastes and manures, in which nitrogen is extracted as an aqueous ammonia, and further concentrated, and eventually converted to nitrate in a biological reactor. The method may utilize nitrogen rich organic wastes and manures, such as wastewater sludge, slaughter house wastes, broiler layer, and guano, and it is especially suitable for providing a nitrogen fertilizer in organic farming.
    Type: Grant
    Filed: November 7, 2006
    Date of Patent: March 9, 2010
    Assignee: Ben Gurion University of the Negev Research and Development Authority
    Inventors: Amit Gross, Ali Nejidat, Pinchas Fine
  • USE OF 2,2,3,3, TETRAMETHYLCYCLOPROPANE CARBOXYLIC ACID DERIVATIVES FOR TREATING PSYCHIATRIC DISORDERS
    Publication number: 20100048721
    Abstract: The invention relates to the use of 2,2,3,3 tetramethylcyclopropane carboxylic acid derivative compounds for the preparation of a medicament for treating a psychiatric disorder preferably a bipolar disorder. The invention additionally relates to the use of the compounds for the preparation of an inhibitor of MIP synthase and to a pharmaceutical composition comprising the compounds for treating a psychiatric disorder. A method for treating a psychiatric disorder preferably a bipolar disorder and a method for inhibiting an enzyme having MIP synthase activity is provided.
    Type: Application
    Filed: May 27, 2004
    Publication date: February 25, 2010
    Applicants: Yissum Research Development Co. of the Hebrew University of Jerusalem, Ben Gurion University of the Negev Research and Development Authority
    Inventors: Meir BIALER, Boris YAGEN, Haim BELMAKER, Galila AGAM, Galit SHALTIEL