Patents Assigned to BENEVOLENTAI CAMBRIDGE LIMITED
  • Compounds I
    Patent number: 11040969
    Abstract: The present invention relates to compounds of formula (I), and their pharmaceutically acceptable salts, solvates, hydrates, geometrical isomers, tautomers, optical isomers or N-oxides, which are inhibitors of SSAO activity. The invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the treatment of medical conditions wherein inhibition of SSAO activity is beneficial, such as inflammatory diseases and immune disorders.
    Type: Grant
    Filed: July 17, 2019
    Date of Patent: June 22, 2021
    Assignee: BENEVOLENTAI CAMBRIDGE LIMITED
    Inventors: Edward Savory, Michael Higginbottom, Kathryn Oliver, Viet-Anh Anne Horgan
  • PROCESS FOR THE PREPARATION OF (3S,4S)-TETRAHYDROFURAN-3-YL 4-ISOPROPYL-6,7-DIHYDRO-3H-IMIDAZO[4,5-C]PYRIDINE-5(4H)-CARBOXYLATE
    Publication number: 20200062746
    Abstract: The invention relates to an improved process for the synthesis of (3S,4S)-tetrahydrofuran-3-yl 4-isopropyl-6,7-dihydro-3H-imidazo[4,5-c]pyridine-5(4H)-carboxylate, and pharmaceutically acceptable salts thereof, such as the methanesulphonic acid salt.
    Type: Application
    Filed: October 25, 2017
    Publication date: February 27, 2020
    Applicant: Benevolentai Cambridge Limited
    Inventors: Anne HORGAN, Olof HAGLUND, Lee PATIENT, Edward SAVORY, Michael HIGGINBOTTOM, Michael ASHWOOD
  • COMPOUNDS I
    Publication number: 20190359611
    Abstract: The present invention relates to compounds of formula (I), and their pharmaceutically acceptable salts, solvates, hydrates, geometrical isomers, tautomers, optical isomers or N-oxides, which are inhibitors of SSAO activity. The invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the treatment of medical conditions wherein inhibition of SSAO activity is beneficial, such as inflammatory diseases and immune disorders.
    Type: Application
    Filed: July 17, 2019
    Publication date: November 28, 2019
    Applicant: BENEVOLENTAI CAMBRIDGE LIMITED
    Inventors: Edward SAVORY, Michael HIGGINBOTTOM, Kathryn OLIVER, Viet-Anh Anne HORGAN
  • Compounds I
    Patent number: 10399973
    Abstract: The present invention relates to compounds of formula (I), and their pharmaceutically acceptable salts, solvates, hydrates, geometrical isomers, tautomers, optical isomers or N-oxides, which are inhibitors of SSAO activity. The invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the treatment of medical conditions wherein inhibition of SSAO activity is beneficial, such as inflammatory diseases and immune disorders.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: September 3, 2019
    Assignee: BENEVOLENTAI CAMBRIDGE LIMITED
    Inventors: Edward Savory, Michael Higginbottom, Kathryn Oliver, Viet-Anh Anne Horgan
  • Crystalline compound as semicarbazide-sensitive amine oxidase (SSAO) enzyme inhibitor
    Patent number: 10369139
    Abstract: A specific crystalline mesylate salt form of (3S)-Tetrahydrofuran-3-yl (4S)-4-isopropyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylate, and the use of the same in medicine. (Formula (I)).
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: August 6, 2019
    Assignee: BENEVOLENTAI CAMBRIDGE LIMITED
    Inventor: Edward Savory
  • Pharmaceutical salt forms of an inhibitor of semicarbazide-sensitive amine oxidase (SSAO)
    Patent number: 10316034
    Abstract: The mesylate and sulphate salts of (3S)-Tetrahydrofuran-3-yl (4S)-4-isopropyl-,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylate mesylate, and hydrates thereof, and their use in medicine.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: June 11, 2019
    Assignee: BENEVOLENTAI CAMBRIDGE LIMITED
    Inventors: Edward Savory, Michael Higginbottom
  • VAP-1 INHIBITORS FOR TREATING PAIN
    Publication number: 20180360808
    Abstract: This invention relates to the use of inhibitors of VAP-1/SSAO activity, and pharmaceutical compositions comprising the same, for the treatment of pain; and to a combined preparation comprising an inhibitor of VAP-1/SSAO activity and a steroid, and the use of the combined preparation in medicine, particularly for treatment of pain.
    Type: Application
    Filed: December 7, 2016
    Publication date: December 20, 2018
    Applicant: BENEVOLENTAI CAMBRIDGE LIMITED
    Inventors: Martyn PRITCHARD, Peter RICHARDSON