Patents Assigned to Berg Pharma LLC
  • METHODS FOR TREATMENT OF ONCOLOGICAL DISORDERS USING AN EPIMETABOLIC SHIFTER (COENZYME Q10)
    Publication number: 20150023940
    Abstract: Methods and formulations for treating oncological disorders in humans using Coenzyme Q10 are described.
    Type: Application
    Filed: February 3, 2014
    Publication date: January 22, 2015
    Applicant: BERG PHARMA LLC
    Inventors: Niven Rajin Narain, John Patrick McCook
  • METHODS AND USE OF INDUCING APOPTOSIS IN CANCER CELLS
    Publication number: 20150010614
    Abstract: The present disclosure relates to a method of inducing apoptosis in a cancer cell by delivery of exogenous Coenzyme Q1O or its metabolites thereof in a pharmaceutically acceptable carrier to effectuate cell contact of endogenous Coenzyme Q1O or its metabolites thereof in addition to but not limited to mevalonic acid and oleic add to form an intracellular complex. The present disclosure also provides a method of modulating the p53 pathway and Bcl-2 protein family in a manner that restores the apoptotic potential to a cancer cell by delivery of Coenzyme Q1O in a pharmaceutically acceptable carrier. The present disclosure further provides a method to specifically normalize the ratio of pro-apoptotic and anti-apopotic members of the Bcl-2 gene family in a proportion to re-program a cancer cell to undergo apoptosis.
    Type: Application
    Filed: February 10, 2014
    Publication date: January 8, 2015
    Applicant: BERG PHARMA LLC
    Inventors: Niven Rajin Narain, Indushekhar Persaud, John Patrick McCook
  • INHALABLE PHARMACEUTICAL COMPOSITIONS
    Publication number: 20140239525
    Abstract: Inhalable pharmaceutical compositions can include an aqueous dispersion of particles including a hydrophobic bioactive agent (e.g., CoQIO) suitable for continuous aerosolization. Due to their chemical composition and methods of manufacture, the pharmaceutical compositions exhibit distinctive physicochemical properties that provide advantageous aerosol transmission and output.
    Type: Application
    Filed: June 18, 2012
    Publication date: August 28, 2014
    Applicants: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM, BERG PHARMA LLC
    Inventors: Jason Thomas McConville, Thiago Cordoso Carvalho, Niven Rajin Narain, John Patrick McCook
  • METHODS OF TREATING A METABOLIC SYNDROME BY MODULATING HEAT SHOCK PROTEIN (HSP) 90-BETA
    Publication number: 20140154266
    Abstract: The invention provides methods of treatment of metabolic syndrome with HSP90 inhibitors, particularly HSP90? inhibitors. The invention provides methods of diagnosis and monitoring of metabolic syndrome using HSP90, particularly HSP90?, expression and activity level.
    Type: Application
    Filed: May 24, 2013
    Publication date: June 5, 2014
    Applicant: BERG PHARMA LLC
    Inventors: Niven Rajin Narain, Rangaprasad Sarangarajan, Vivek K. Vishnudas, Enxuan Jing
  • INTERROGATORY CELL-BASED ASSAYS AND USES THEREOF
    Publication number: 20130259847
    Abstract: Described herein is a discovery Platform Technology for analyzing a biological system or process (e.g.
    Type: Application
    Filed: September 7, 2012
    Publication date: October 3, 2013
    Applicant: BERG PHARMA LLC
    Inventors: Vivek K. Vishnudas, Rangaprasad Sarangarajan, Niven Rajin Narain, Min Du, Tony Walshe
  • TOPICAL FORMULATIONS HAVING ENHANCED BIOAVAILABILITY
    Publication number: 20130202683
    Abstract: The present disclosure provides compositions suitable for delivering lipophilic bioactive agents. The compositions may be utilized to treat numerous diseases and conditions that would benefit from the application of a lipophilic bioactive agent.
    Type: Application
    Filed: January 28, 2013
    Publication date: August 8, 2013
    Applicant: BERG PHARMA LLC
    Inventor: BERG PHARMA LLC
  • Topical formulations having enhanced bioavailability
    Patent number: 8454945
    Abstract: The present disclosure provides compositions suitable for delivering lipophilic bioactive agents. The compositions may be utilized to treat numerous diseases and conditions that would benefit from the application of a lipophilic bioactive agent.
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: June 4, 2013
    Assignee: Berg Pharma LLC
    Inventors: John Patrick McCook, Indushekhar Persaud, Niven Rajin Narain