Abstract: Described are antibodies that specifically bind to the Axl protein and inhibit the interaction between Axl and the Axl-ligand, Gas6. Also disclosed are methods for the production and use of the anti-Axl antibodies.

Abstract: The present disclosure relates to antibodies that specifically bind a novel epitope on the Axl protein. Also disclosed are methods for the production and use of the anti-Axl antibodies.

Abstract: Described are antibodies that specifically bind to the Axl protein and inhibit the interaction between Axl and the Axl-ligand, Gas6. Also disclosed are methods for the production and use of the anti-Axl antibodies.

Abstract: The present disclosure relates to antibodies that specifically bind a novel epitope on the Axl protein. Also disclosed are methods for the production and use of the anti-Axl antibodies.

Abstract: The present disclosure relates to antibodies that specifically bind a novel epitope on the AxI protein. Also disclosed are methods for the production and use of the anti-Axl antibodies.

Abstract: The present disclosure relates to antibodies that specifically bind a novel epitope on the Axl protein. Also disclosed are methods for the production and use of the anti-Axl antibodies.

Abstract: A method of predicting model parameters (R1, R2, R3, . . . ) of a geological formation under investigation, wherein said geological formation is distinguished by reservoir parameters including observable data parameters and the model parameters (R1, R2, R3, . . . ) to be predicted, comprises the steps of calculating at least one model constraint (M1, M2, M3, . . . ) of the model parameters (R1, R2, R3, . . . ) by applying at least one rock physics model (f1, f2, f3, . . . ) on the model parameters (R1, R2, R3, . . . ), said at least one model constraint (M1, M2, M3, . . . ) including modelled data of at least one of the data parameters, and applying an inverse model solver process on observed input data (d1, d2, d3, . . . ) of at least one of the data parameters, including calculating predicted model parameters, which comprise values of the model parameters (R1, R2, R3, . . .

Abstract: The present invention relates to compounds of formula (I) as defined in the specification for use as pharmacological chaperones having a stabilizing effect on phenylalanine hydroxylase (PAH) for the treatment of hyperphenylalaninemia (HPA), in particular phenylketonuria (PKU). The compounds include trimethoprim and analogues and derivatives thereof.

Abstract: Provided herein is technology relating to natural lipids containing non-?-oxidizable fatty acids and particularly, but not exclusively, to compositions and methods related to the production and use of natural lipids containing non-?-oxidizable fatty acids.

Abstract: The present invention relates to processes to make neosaxitoxin, and analogues and variants thereof, and intermediates in the production of neosaxitoxin in recombinant host cells. Neosaxitoxin and the analogues and variants thereof may be used in the production of pharmaceutical compositions.

Abstract: The present invention relates to compounds of formula (I) as defined in the specification for use as pharmacological chaperones having a stabilizing effect on phenylalanine hydroxylase (PAH) for the treatment of hyperphenylalaninemia (HPA), in particular phenylketonuria (PKU). The compounds include trimethoprim and analogues and derivatives thereof.

Abstract: A mutant of an E coli heat-stable toxin (ST) having the following wild-type sequence: NSSNYCCELCCNPACTGCY wherein the mutant comprises a mutation selected from the group consisting of: A14H, A14T and N12T.

Abstract: A method of predicting model parameters (R1, R2, R3, . . . ) of a geological formation under investigation, wherein said geological formation is distinguished by reservoir parameters including observable data parameters and the model parameters (R1, R2, R3, . . . ) to be predicted, comprises the steps of calculating at least one model constraint (M1, M2, M3, . . . ) of the model parameters (R1, R2, R3, . . . ) by applying at least one rock physics model (f1, f2, f3, . . . ) on the model parameters (R1, R2, R3, . . . ), said at least one model constraint (M1, M2, M3, . . . ) including modelled data of at least one of the data parameters, and applying an inverse model solver process on observed input data (d1, d2, d3, . . . ) of at least one of the data parameters, including calculating predicted model parameters, which comprise values of the model parameters (R1, R2, R3, . . .

Abstract: A method of processing three-dimensional image data for volume-rendering from a viewpoint is described. Lower- and upper-bound-generating functions are used (7) to determine whether, across all possible values for the image voxels between respective lower and upper bounds, for each voxel (i) the voxel may be at least partially opaque under the opacity transfer function (8); and (ii) the voxel may be unoccluded from the viewpoint (9). A predetermined processing operation is then applied to these potentially-visible voxels, for which both determinations hold true (10) and the processed voxels may be rendered (11). The bound-generating functions and the processing operation are such that, for any three-dimensional image data, the value of a voxel after the processing operation will necessarily lie between the lower and upper bounds for that voxel.

Abstract: Novel phenazine derivatives, methods for their preparation and their medical use, in particular as anti-neoplastic agents and anti-infective agents, are provided. Novel methods for the preparation of iodinin and myxin are also provided.

Abstract: A method of investigating a solid sample, in particular a geological sample, such as a borehole core sample, includes the steps of positioning the sample on a sample support device, positioning a hyperspectral camera device, so that a line-shaped surface region of the sample is covered by a field of view of the hyperspectral camera device, illuminating the sample on the sample support device, moving the hyperspectral camera device and the sample support device relative to each other, wherein the field of view of the hyperspectral camera device is moved along a scanning direction over the surface of the sample, and collecting a hyperspectral image of the sample during the moving step, wherein the hyperspectral image is composed of multiple hyperspectral line images.

Abstract: A method of investigating a solid sample, in particular a geological sample, such as a borehole core sample, includes the steps of positioning the sample on a sample support device, positioning a hyperspectral camera device, so that a line-shaped surface region of the sample is covered by a field of view of the hyperspectral camera device, illuminating the sample on the sample support device, moving the hyperspectral camera device and the sample support device relative to each other, wherein the field of view of the hyperspectral camera device is moved along a scanning direction over the surface of the sample, and collecting a hyperspectral image of the sample during the moving step, wherein the hyperspectral image is composed of multiple hyperspectral line images.