Patents Assigned to Bergen Teknologioverforing AS
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Publication number: 20180246080Abstract: The present invention relates to the use of Axl as a biomarker for detecting the occurrence of epithelial-to-mesenchymal transition (EMT) in a subject. More specifically, the invention relates to various methods for detecting the occurrence of epithelial-to-mesenchymal transition (EMT) in a subject by measuring Axl expression and/or activity.Type: ApplicationFiled: December 8, 2017Publication date: August 30, 2018Applicant: BERGEN TEKNOLOGIOVERFORING ASInventors: James Bradley Lorens, David Robert Micklem, Lars A. Akslen
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Publication number: 20170349658Abstract: Described are antibodies that specifically bind to the Axl protein and inhibit the interaction between Axl and the Axl-ligand, Gas6. Also disclosed are methods for the production and use of the anti-Axl antibodies.Type: ApplicationFiled: December 18, 2015Publication date: December 7, 2017Applicants: BERGEN TEKNOLOGIOVERFORING AS, BERGENBIO ASInventors: David Robert MICKLEM, Sergej KIPRIJANOV, James Bradley LORENS, Lavina AHMED, Linn Hodneland NILSSON, Tone SANDAL
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Patent number: 9795953Abstract: The present invention refers to novel ruthenium- and osmium-based catalysts for olefin metathesis reactions, particularly to catalysts having stereoselective properties. Z-selectivity is obtained by utilizing two mono-anionic ligands of very different steric requirement. In olefin metathesis reactions these catalysts selectively provide the Z-isomer of disubstituted olefinic products even in presence of air or of acids.Type: GrantFiled: March 31, 2016Date of Patent: October 24, 2017Assignee: Bergen Teknologioverforing ASInventors: Vidar R. Jensen, Giovanni Occhipinti
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Publication number: 20170287206Abstract: A method of processing three-dimensional image data for volume-rendering from a viewpoint is described. Lower- and upper-bound-generating functions are used (7) to determine whether, across all possible values for the image voxels between respective lower and upper bounds, for each voxel (i) the voxel may be at least partially opaque under the opacity transfer function (8); and (ii) the voxel may be unoccluded from the viewpoint (9). A predetermined processing operation is then applied to these potentially-visible voxels, for which both determinations hold true (10) and the processed voxels may be rendered (11). The bound-generating functions and the processing operation are such that, for any three-dimensional image data, the value of a voxel after the processing operation will necessarily lie between the lower and upper bounds for that voxel.Type: ApplicationFiled: September 2, 2015Publication date: October 5, 2017Applicant: BERGEN TEKNOLOGIOVERFØRING ASInventors: Veronika Solteszova, Ivan Viola, Åsmund Birkeland, Stefan Bruckner
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Patent number: 9745273Abstract: Novel phenazine derivatives, methods for their preparation and their medical use, in particular as anti-neoplastic agents and anti-infective agents, are provided. Novel methods for the preparation of iodinin and myxin are also provided.Type: GrantFiled: November 3, 2014Date of Patent: August 29, 2017Assignees: Universitetet I Oslo, Bergen Teknologioverføring AS, Université Claude Bernard Lyon 1Inventors: Stein Ove Døskeland, Pål Rongved, Lars Herfindal, Marc Le Borgne, Elvar Örn Viktorsson, Ove Alexander Høgmoen Åstrand
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Patent number: 9512484Abstract: A method for determining a prognosis for survival for a patient with breast cancer is described. Also described is a method for monitoring the effectiveness of a course of treatment for a patient with breast cancer, and the use of such a method in a kit. A kit determining the level of RINF is also described.Type: GrantFiled: December 8, 2009Date of Patent: December 6, 2016Assignee: Bergen Teknologioverforing ASInventors: Frederic Pendino, Johan R. Lillehaug, Thomas Aloysius, Stian Knappskog
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Patent number: 9457347Abstract: The present invention refers to novel ruthenium- and osmium-based catalysts for olefin metathesis reactions, particularly to catalysts having stereoselective properties. Z-selectivity is obtained by utilizing two mono-anionic ligands of very different steric requirement. In olefin metathesis reactions these catalysts selectively provide the Z-isomer of disubstituted olefinic products.Type: GrantFiled: May 2, 2014Date of Patent: October 4, 2016Assignee: Bergen Teknologioverforing ASInventors: Vidar R. Jensen, Giovanni Occhipinti, Frederik R. Hansen
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Patent number: 9303100Abstract: The present invention refers to novel ruthenium- and osmium-based catalysts for olefin metathesis reactions, particularly to catalysts having stereoselective properties. Z-selectivity is obtained by utilizing two mono-anionic ligands of very different steric requirement. In olefin metathesis reactions these catalysts selectively provide the Z-isomer of disubstituted olefinic products even in presence of air or of acids.Type: GrantFiled: July 17, 2014Date of Patent: April 5, 2016Assignee: Bergen Teknologioverforing ASInventors: Vidar R. Jensen, Giovanni Occhipinti
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Publication number: 20150153326Abstract: A method for a microscope-based quantitative analysis of contact-dependent cell-to-cell transfer between cells. Single donor cells containing a traceable marker are cultured in a lawn of acceptor cells to allow cell-to-cell transfers. The donor and acceptor cells are then imaged and/or stained for microscopy to determine the location, shape and volumes of donor cells and of surrounding acceptor cells within selected regions of interest. The spatial distribution of the traceable marker in each volumetric picture element of the region of interest is determined and analyzed to determine quantitatively and qualitatively the substance transfer. The method allows a reliable quantitative evaluation of the effect of an active agent on cell-to-cell molecular communication and disease transmission.Type: ApplicationFiled: November 25, 2014Publication date: June 4, 2015Applicant: Bergen Teknologioverforing AS, BTOInventors: Tanja Kögel, Erlend Hodneland, Hans-Hermann Gerdes, Dominik Michael Frei, Anne Burtey
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Publication number: 20150079223Abstract: Animal feeds and feed components are provided which comprise tunicate material. The tunicate material may be whole tunicate, e.g. washed and/or dried, or a tunicate extract. Preferred tunicate extracts include protein- and/or lipid-enhanced extracts. Also provided are uses of tunicates and tunicate extracts as, or in, animal feeds and methods for feeding animals, e.g. fish, comprising administering feeds containing tunicate material.Type: ApplicationFiled: December 17, 2012Publication date: March 19, 2015Applicant: BERGEN TEKNOLOGIOVERFORING ASInventors: Christofer Troedsson, Eric Thompson, Jean-Marie Bouquet, Thorolf Magnesen, Christoffer Schander, Jiebing Li
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Publication number: 20140357478Abstract: The present invention refers to novel ruthenium- and osmium-based catalysts for olefin metathesis reactions, particularly to catalysts having stereoselective properties. Z-selectivity is obtained by utilising two mono-anionic ligands of very different steric requirement. In olefin metathesis reactions these catalysts selectively provide the Z-isomer of disubstituted olefinic products.Type: ApplicationFiled: May 2, 2014Publication date: December 4, 2014Applicant: Bergen Teknologioverforing ASInventors: Vidar R. Jensen, Giovanni Occhipinti, Frederick R. Hansen
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Publication number: 20140200155Abstract: The present invention relates to a method for diagnosing or determining the status of endometrial carcinoma in an individual afflicted with or suspected to be afflicted with endometrial carcinoma based on the phosphorylated stathmin compound whereby said stathmin is phosphorylated at position Serine 38. Moreover, the present invention relates to a method for evaluating the probability of survival, the clinical outcome or the treatment course of an individual afflicted with or suspected to be afflicted with endometrial carcinoma. In another aspect, the present invention relates to the stratification of the therapeutic regimen of an individual with endometrial carcinoma. In particular, the present invention provides a method for diagnosing or identifying endomentrial carcinoma with high grade aggressive phenotype, in particular, having low response and susceptibility to chemotherapeutic regimen, in particular, with respect to microtubule stabilization based regimen including treatment with taxanes.Type: ApplicationFiled: January 15, 2014Publication date: July 17, 2014Applicant: Bergen Teknologioverforing ASInventors: Helga B. SALVESEN, Jone TROVIK, Lars Andreas AKSLEN, Elisabeth WIK
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Patent number: 8763710Abstract: A method of recovering oil from a heterogeneous reservoir, comprising a plurality of permeable porous blocks of rock whose pores contain oil and which form interfaces with regions between the blocks, e.g. fractures, having a higher permeability than the blocks. Treating the interfaces such that the wettability of the surfaces of the blocks is in a predetermined wettability range, then reducing the permeability in the highly permeable regions, and finally flooding the reservoir by injecting a chase fluid into the reservoir. With the present method, water phase bridges are established between adjacent blocks in the reservoir thus allowing a transmission of injection pressure for viscous displacement from one block to the next across the reservoir. A method for long-time storage of CO2 by using CO2 as chase fluid or foaming gas according to the present method for oil recovery from heterogeneous reservoirs.Type: GrantFiled: July 21, 2010Date of Patent: July 1, 2014Assignee: Bergen Teknologioverforing ASInventor: Arne Graue
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Patent number: 8716488Abstract: The present invention refers to novel ruthenium- and osmium-based catalysts for olefin metathesis reactions, particularly to catalysts having stereoselective properties. Z-selectivity is obtained by utilizing two mono-anionic ligands of very different steric requirement. In olefin metathesis reactions these catalysts selectively provide the Z-isomer of disubstituted olefinic products.Type: GrantFiled: September 25, 2012Date of Patent: May 6, 2014Assignee: Bergen Teknologioverforing ASInventors: Vidar R. Jensen, Giovanni Occhipinti, Frederick Rosberg Hansen
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Patent number: 8673027Abstract: The present invention refers to a method of converting a lignin material into a liquid product and the liquid product obtainable by the method.Type: GrantFiled: August 13, 2008Date of Patent: March 18, 2014Assignee: Bergen Teknologioverforing ASInventors: Mike Kleinert, Tatjana (Tanja) Barth
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Publication number: 20140020283Abstract: This invention relates to the use of a tunicate or an extract obtained from a tunicate for the production of one or more biofuel selected from an alcohol and biodiesel. The invention also relates to a method for producing a biofuel from a tunicate wherein the biofuel is selected from an alcohol and biodiesel and wherein said method comprises the steps of: (a)(i) subjecting said tunicate or one or more polysaccharides extracted from said tunicate to enzymatic or acid hydrolysis to form a hydrolysate containing one or more monosaccharides and (ii) fermenting said one or more monosaccharides to form an alcohol; or (b)(i) extracting lipids/fatty acids from said tunicate and (ii) converting said lipids/fatty acids into biodiesel by transesterification or alcoholysis or (iii) subjecting said tunicate to transesterification or alcoholysis thereby converting lipids/fatty acids present in said tunicate into biodiesel.Type: ApplicationFiled: June 17, 2011Publication date: January 23, 2014Applicant: Bergen Teknologioverforing ASInventor: Willy Dalheim
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Publication number: 20130267440Abstract: The present invention relates to a method for diagnosis of different stages of endometrial cancer in an individual. Further, the present invention relates to a method for evaluating the probability of survival for an individual suffering from endometrial carcinoma. In another aspect, the present invention relates to the stratification of therapy regimen of endometrial tumor, ovarian cancer, breast cancer, non-small lung cancer or hormone refractory prostate cancer therapy in an individual or monitoring therapeutic efficacy in an individual suffering from the same based on the expression status of STMN1 gene or protein. Moreover, the present invention relates to a kit for use in any of the above referenced methods comprising a means for determining amplifications and deletions of chromosomal regions 3q26.32 and 12p12.Type: ApplicationFiled: December 8, 2011Publication date: October 10, 2013Applicant: BERGEN TEKNOLOGIOVERFORING ASInventors: Helga B. Salvesen, Lars A. Akslen, Jone Trovik, Henrica Maria Johanna Werner
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Publication number: 20130217590Abstract: A method for determining a prognosis for survival for a patient with leukaemia is described. Also described is a method for monitoring the effectiveness of a course of treatment for a patient with leukaemia, and the use of such a method in a kit. A kit determining the level of RINF is also described.Type: ApplicationFiled: July 21, 2011Publication date: August 22, 2013Applicant: BERGEN TEKNOLOGIOVERFORINGInventors: Frederic Pendino, Pierre De La Grange, Johan R. Lillehaug, Thomas Aloysius, Stian Knappskog
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Publication number: 20130023665Abstract: The present invention refers to novel ruthenium- and osmium-based catalysts for olefin metathesis reactions, particularly to catalysts having stereoselective properties. Z-selectivity is obtained by utilising two mono-anionic ligands of very different steric requirement. In olefin metathesis reactions these catalysts selectively provide the Z-isomer of disubstituted olefinic products.Type: ApplicationFiled: September 25, 2012Publication date: January 24, 2013Applicant: Bergen Teknologioverforing ASInventor: Bergen Teknologioverforing AS
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Publication number: 20120159655Abstract: The present invention relates to the use of AxI as a biomarker for detecting the occurrence of epithelial-to-mesenchymal transition (EMT) in a subject. More specifically, the invention relates to various methods for detecting the occurrence of epithelial-to-mesenchymal transition (EMT) in a subject by measuring AxI expression and/or activity.Type: ApplicationFiled: March 1, 2010Publication date: June 21, 2012Applicant: Bergen Teknologioverforing ASInventors: James Bradley Lorens, David Robert Micklem, Lars A. Akslen