Patents Assigned to Berlex Biosciences Inc.
  • 6-azido-2-fluoropurine, useful in the synthesis of nucleosides
    Patent number: 5180824
    Abstract: This invention pertains to novel methods of synthesizing fludarabine, fludarabine phosphate and related nucleoside pharmacologic agents utilizing 6-azido-2-fluoropurine as a novel intermediate.In particular this invention pertains to a synthesis of fludarabine where the relatively low yield fluorination step is done before the costly coupling step.
    Type: Grant
    Filed: November 29, 1990
    Date of Patent: January 19, 1993
    Assignee: Berlex Biosciences Inc.
    Inventors: John G. Bauman, Randolph C. Wirsching