Abstract: The current invention is related to a method for the production of a human monoclonal antibody from a immunodeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently contacting said reconstituted animal with a antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.
Type:
Grant
Filed:
March 13, 2013
Date of Patent:
November 11, 2014
Assignees:
Bernd Mueller-Beckmann
Inventors:
Alexander Lifke, Valeria Lifke, Bernd Mueller-Beckmann, Tobias Schnitzer