Abstract: A pharmaceutical product containing ?2-microglobulin or a functional variant thereof as an active ingredient in the form of liposomes is provided. The product can increase the concentration of ?2-microglobulin in the blood, and can also restore a normal HC/?2-microglobulin molar ratio within membrane MHC-I complexes, or prevent a ?2-microglobulin deficit from occurring in the MHC-I complexes, of patients suffering from autoimmune diseases. Methods of treating patients with the pharmaceutical product are also presented.
Abstract: Novel sterol derivatives, the preparation method thereof, pharmaceutical compositions containing them and use thereof for treating diseases involving transformed astrocyte cells or for treating malignant haemopathies. The treatment of glioblastoma multiforme, as well as of other cancers, such as lymphomas, neuroblastomas and melanomas is also described.
Type:
Grant
Filed:
May 7, 2013
Date of Patent:
October 13, 2020
Assignee:
BETA INNOV
Inventors:
Ludovic Clarion, Marcel Mersel, Didier Petite
Abstract: Novel sterol derivatives, the preparation method thereof, pharmaceutical compositions containing them and use thereof for treating diseases involving transformed astrocyte cells or for treating malignant haemopathies. The treatment of glioblastoma multiforme, as well as of other cancers, such as lymphomas, neuroblastomas and melanomas is also described.
Type:
Application
Filed:
May 7, 2013
Publication date:
March 26, 2015
Applicant:
BETA INNOV
Inventors:
Ludovic Clarion, Marcel Mersel, Didier Petite
Abstract: The use of beta2-microglobulin (?2m) as active ingredient, in particular in pharmaceutical compositions intended for the treatment of autoimmune diseases.