Abstract: The present invention relates to a transdermal delivery device for estradiol where the metabolic degradation of estradiol to estrone during permeation is inhibited by another substance in the transdermal delivery device. The transdermal device also includes a compound for enhancing the rate of estradiol permeation. The transdermal delivery device containing the inhibitor and enhancer can also be used to simultaneously deliver both estradiol and a progestin at therapeutic rates.
Type:
Grant
Filed:
January 11, 1996
Date of Patent:
January 6, 1998
Assignee:
Beta Pharmaceuticals Co.
Inventors:
Francisco Jose Evaristo Stefano, Jose Adrian Nowogrodski, Dario Norberto Ramon Carrara
Abstract: The present invention relates to a transdermal delivery device for estradiol where the metabolic degradation of estradiol to estrone during permeation is inhibited by another substance in the transdermal delivery device. The transdermal device also includes a compound for enhancing the rate of estradiol permeation. The transdermal delivery device containing the inhibitor and enhancer can also be used to simultaneously deliver both estradiol and a progestin at therapeutic rates.
Type:
Grant
Filed:
March 2, 1993
Date of Patent:
May 21, 1996
Assignee:
Beta Pharmaceuticals Co.
Inventors:
Francisco J. Stefano, Jose A. Nowogrodski, Dario N. Carrara