Abstract: The present invention refers to a method for producing a human insulin analogue with high efficiency and excellent yield, by means of a biotechnological process comprising transformation of a Pichia pastoris yeast strain. In particular, the invention refers to a biotechnological process for obtaining aspart insulin.

Abstract: The present invention refers to a method for producing a human insulin analogue with high efficiency and excellent yield, by means of a biotechnological process comprising transformation of a Pichia pastoris yeast strain. In particular, the invention refers to a biotechnological process for obtaining aspart insulin.

Abstract: Methylotrophic recombinant yeast strain producing human insulin precursor, the strain comprising, in its genome, a copy of a first DNA construction and a second DNA construction, wherein the constructions are capably of directing the expression and secretion of human insulin precursor of the formula B(1-30)-Y1-Y2-A(1-21), wherein Y1 is lysine or arginine; Y2 is lysine or arginine; B(1-30) is the B peptide of the human insulin; and B(1-21) is the A peptide of human insulin, and wherein the strain is yeast Pichia Pastoris. DNA constructions and method for obtaining the strain are also provided.

Abstract: The present invention relates to spironolactone contain compositions for application to an area of human skin afflicted with acne, seborrheic condition or hirsutism. N,N-dialkyl lauramides are used as permeation enhancers.

Abstract: The disclosure concerns apparatus for stacking folded laundry. A pair of clamping jaws is supported for swinging about a swinging axis. A first pneumatic cylinder is connected through a first rack with a first pinion connected with the first clamping jaw. A second pneumatic cylinder is connected through a second rack with a second pinion connected with the other clamping jaw. The first pneumatic cylinder is stronger than the second pneumatic cylinder, whereby when both pneumatic cylinders are operated, the first pneumatic cylinder swings the clamping jaws together around the swinging axis to deliver laundry to a stacking table and the second pneumatic cylinder acts in opposition to the first pneumatic cylinder to cause the clamping jaws to clamp together.

Abstract: A machine for cleaning cup-shaped filters, particularly those for "expresso" coffee, having a substantially closed casing divided into an upper and a lower portion, the upper portion containing a brush shaped in the form of a cup and driven by an electric motor disposed outside of the casing, a hopper narrowing downwardly in the casing for collecting coffee grounds and a bag container releaseably positioned in the lower part connected to the hopper for receiving the coffee grounds. The casing is provided with an opening adjacent the brush for insertion of the filter to be cleaned.

Abstract: A loading station located at one side of a feeding conveyor, into which the corners of a sheet can be loaded. The station comprises two movable clamping devices supported on a track which runs across the rear of the feeding conveyor. Each clamping device is driven by an independent transmission system, the two transmission systems are connected to a selfcentering interlock mechanism. The centering mechanism is arranged to permit independent movement of the two clamping mechanisms, whereby they can move from the side position into a position in front of the feeding conveyor. The centering mechanism will then automatically control the tensioning and positioning of the leading edge of the sheet which is held by the clamping devices irrespective of the width of the sheet.This will result in the center of the sheet being positioned in line with the required feeding center of the feed conveyor.