Abstract: Compositions and methods useful for the prevention or treatment of a human or animal disorder or for the regulation of the human or animal physiological condition are provided. The compositions used comprise, in admixture, a biologically-effective amount of a drug specific for the disorder or condition and a biocompatible, water-soluble, amphiphilic steroid, other than a natural bile salt, which is capable of increasing drug permeability of the human or animal body surface across which the drug is to be administered, in an amount effective to increase the permeability of the surface to the drug.
Type:
Grant
Filed:
May 23, 1988
Date of Patent:
September 25, 1990
Assignees:
Beth Israel Hospital Assn., The Brigham and Womens Hospital, Inc.
Inventors:
Martin C. Carey, Alan C. Moses, Jeffrey S. Flier
Abstract: Compositions and methods useful for the prevention or treatment of a human or animal disorder or for the regulation of a human or animal physiological condition are provided. The compositions used comprise, in admixture, a biologically-effective amount of a drug specific for the disorder or condition and a biocompatible, water-soluble, amphiphilic steroid, other than a natural bile salt, which is capable of increasing drug permeability of the human or animal body surface across which the drug is to be administered, in an amount effective to increase the permeability of the surface to the drug.
Type:
Grant
Filed:
May 25, 1984
Date of Patent:
May 24, 1988
Assignees:
Beth Israel Hospital Assn., The Brigham and Womens Hospital, Inc.
Inventors:
Martin C. Carey, Alan C. Moses, Jeffrey S. Flier