Abstract: An ex-vivo brain perfusion system for perfusion of a brain includes a reservoir configured to receive perfusate, a housing configured to contain the brain, an arterial circuit configured to fluidly couple the reservoir to the brain, a venous circuit fluidly coupling the housing to the reservoir, and a syringe pump fluidly coupled to the reservoir and configured to introduce a therapeutic agent to the perfusate in the reservoir. The ex-vivo brain perfusion system is configured to perfuse the brain with the therapeutic agent to test at least one property of the therapeutic agent.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for predicting data characterizing a state or biological function of a brain. In one aspect, a method comprises obtaining, for each of a plurality of mammalian brains, respective multi-modal experimental data that characterizes a state of the mammalian brain during or after an artificial perfusion of the mammalian brain by an electromechanical perfusion device; generating a knowledge graph that jointly represents the multi-modal experimental data characterizing the plurality of mammalian brains, the knowledge graph comprising a set of nodes that each represent elements of the multi-modal experimental data and a set of edges that each represent a relationship between a respective pair of nodes; receiving a query from a user; and generating a response to the query based at least in part on the knowledge graph.