Abstract: The present invention relates to recombinant DNA molecules which encode chimeric polypeptides of differing allergens of Parietaria judaica which can be used for the prevention and treatment of allergies, in particular pollen allergies. Specifically, chimeric polypeptides composed of fragments of the allergens Par j 1 and Par j 2 having hypoallergenic characteristics are described. Methods for producing these recombinant polypeptides in heterologous expression systems are also described. Efficient methods of purifying the chimeric proteins are also described.
Type:
Grant
Filed:
March 5, 2014
Date of Patent:
December 20, 2016
Assignee:
Bial Industrial Farmaceutica, S.A.
Inventors:
Juan Andres Asturias, Alberto Martinez Garate, Roberto Gonzales Rioja
Abstract: The present invention refers to recombinant AND molecules coding to hybrids polypeptides of different allergens from D. pteronyssinus useful for the prevention and treatment of allergies, particularly allergies caused by mites. Specifically, the invention describes hybrid proteins composed of fragments of allergens Derp p 1 y Derp p 2 with hypoallergenic characteristics and maintain their immunogenic capacity, being particularly useful for the treatment of allergy. The invention also describes the production methods of these polypeptides in heterologous expression systems. Besides, the invention describes efficient purification methods of these hybrid proteins.
Type:
Application
Filed:
February 9, 2015
Publication date:
June 4, 2015
Applicant:
BIAL INDUSTRIAL FARMACEUTICA, S.A.
Inventors:
Juan Andrés Asturias Ortega, Iñaki Ibarrola Lopez De Davalillo, Maria Carmen Arilla Rodriguez, Alberto Martinez Garate
Abstract: The present invention refers to recombinant ADN molecules coding to hybrids polypeptides of different allergens from D. pteronyssinus useful for the prevention and treatment of allergies, particularly allergies caused by mites. Specifically, the invention describes hybrid proteins composed of fragments of allergens Derp p 1 y Derp p 2 with hypoallergenic characteristics and maintain their immunogenic capacity, being particularly useful for the treatment of allergy. The invention also describes the production methods of these polypeptides in heterologous expression systems. Besides, the invention describes efficient purification methods of these hybrid proteins.
Type:
Grant
Filed:
March 24, 2009
Date of Patent:
February 10, 2015
Assignee:
Bial Industrial Farmaceutica, S.A.
Inventors:
Juan Andrés Asturias Ortega, Iñaki Ibarrola Lopez De Davalillo, Maria Carmen Arilla Rodriguez, Alberto Martinez Garate
Abstract: The present invention relates to recombinant DNA molecules which encode chimeric polypeptides of differing allergens of Parietaria judaica which can be used for the prevention and treatment of allergies, in particular pollen allergies. Specifically, chimeric polypeptides composed of fragments of the allergens Par j 1 and Par j 2 having hypoallergenic characteristics are described. Methods for producing these recombinant polypeptides in heterologous expression systems are also described. Efficient methods of purifying the chimeric proteins are also described.
Type:
Application
Filed:
March 5, 2014
Publication date:
September 25, 2014
Applicant:
BIAL INDUSTRIAL FARMACEUTICA, S.A.
Inventors:
Juan Andres Asturias, Alberto Martinez Garate, Roberto Gonzales Rioja
Abstract: The present invention relates to recombinant DNA molecules which encode chimeric polypeptides of differing allergens of Parietaria judaica which can be used for the prevention and treatment of allergies, in particular pollen allergies. Specifically, chimeric polypeptides composed of fragments of the allergens Par j 1 and Par j 2 having hypoallergenic characteristics are described. Methods for producing these recombinant polypeptides in heterologous expression systems are also described. Efficient methods of purifying the chimeric proteins are also described.
Type:
Grant
Filed:
April 11, 2007
Date of Patent:
April 15, 2014
Assignee:
Bial Industrial Farmaceutica, S.A.
Inventors:
Juan Andres Asturias Ortega, Alberto Martinez Garate, Roberto Gonzales Rioja
Abstract: The present invention refers to recombinant ADN molecules coding to hybrids polypeptides of different allergens from D. pteronyssinus useful for the prevention and treatment of allergies, particularly allergies caused by mites. Specifically, the invention describes hybrid proteins composed of fragments of allergens Derp p 1 y Derp p 2 with hypoallergenic characteristics and maintain their immunogenic capacity, being particularly useful for the treatment of allergy. The invention also describes the production methods of these polypeptides in heterologous expression systems. Besides, the invention describes efficient purification methods of these hybrid proteins.
Type:
Application
Filed:
March 24, 2009
Publication date:
March 3, 2011
Applicant:
BIAL INDUSTRIAL FARMACEUTICA, S.A.
Inventors:
Juan Andrés Asturias Ortega, Iñaki Ibarrola Lopez De Davalillo, Maria Carmen Arilla Rodriguez, Alberto Martinez Garate
Abstract: The present invention relates to recombinant DNA molecules which encode chimeric polypeptides of differing allergens of Parietaria judaica which can be used for the prevention and treatment of allergies, in particular pollen allergies. Specifically, chimeric polypeptides composed of fragments of the allergens Par j 1 and Par j 2 having hypoallergenic characteristics are described. Methods for producing these recombinant polypeptides in heterologous expression systems are also described. Efficient methods of purifying the chimeric proteins are also described.
Type:
Application
Filed:
April 11, 2007
Publication date:
December 10, 2009
Applicant:
BIAL INDUSTRIAL FARMACEUTICA, S.A.
Inventors:
Juan Andres Asturias Ortega, Alberto Martinez Garate, Roberto Gonzales Rioja