Abstract: An ergonomic musician's pick or pick holder for use with string instruments, such as a guitar, mandolin, bass guitar, or ukelele, has a curved finger grip portion on one side adapted to form a finger cradle for either the thumb or index finger of a user and has a flat generally planar area on another side against which the other fingers of a user may be pressed to allow the user to securely and comfortably grasp the pick for playing. The grip portion positively locates the fingers in a generally predetermined angular relationship to the string engaging pick tip. Different individual picks of the invention may have different angular relationships. The pick functions in the same way to bring the same advantages of the invention to any conventional and some non-standard or custom picks. Holder provides the added advantage that various picks may be used and the angular relationship may be more easily varied through various arrangements for attaching the pick to the holder.