Abstract: The invention provides enantiomers of ajoene and derivatives of Z(?)-ajoene. The derivative of Z(?)-ajoene are useful for modulating integrin-mediated functions, for treating disorders, diseases or conditions in which integrins play a role, and for treating tissues to improve their condition for a subsequent use, such as transplantation.
Type:
Grant
Filed:
May 15, 2006
Date of Patent:
January 22, 2008
Assignee:
Billings Pharmaceuticals, Inc.
Inventors:
John B. Davidson, Alexander V. Tatarintsev, Ali S. Turgiev, James K. Hildreth
Abstract: The invention provides enantiomers of ajoene and derivtives of Z(?)-ajoene. The derivative of Z(?)-ajoene are useful for modulating integrin-mediated functions, for treating disorders, diseases or conditions in which integrins play a role, and for treating tissues to improve their condition for a subsequent use, such as transplantation.
Type:
Grant
Filed:
July 10, 2001
Date of Patent:
May 16, 2006
Assignee:
Billings Pharmaceuticals, Inc.
Inventors:
John B. Davidson, Alexander V. Tatarintsev, Ali S. Turgiev, James K. Hildreth
Abstract: The invention provides methods of treating inflammatory diseases and conditions by administering an effective amount of an integrin modulating agent, as further defined and specified herein, to an animal suffering from one of the diseases or conditions. The preferred integrin modulating agents are ajoene and disintegrins, variants and analogs of disintegrins.
Type:
Grant
Filed:
May 12, 1997
Date of Patent:
January 23, 2001
Assignee:
Billings Pharmaceuticals, Inc.
Inventors:
Alexander V. Tatarintsev, Ali S. Turgiev, John B. Davidson