Abstract: Aspects of the present invention include compositions configured for maintaining health and/or treating progressive degenerative conditions, e.g., hip and joint conditions, kidney conditions, etc., in companion animals. The compositions include supplement formulations and a highly palatable edible backbone, e.g., in the form of a soft chew, tablet or drink. Supplement formulations of interest include one or more naturally occurring active agents which are effective in maintaining health and/or treating a progressive degenerative condition. Methods of maintaining health of and/or treating a companion animal for a progressive degenerative disease by administering the supplement formulations are also provided.