Abstract: A power-assist drive system for a vehicle (e.g., a bicycle) is provided. The system includes a drive unit assembly attached to a frame of a vehicle and a motor having an output shaft, and a drive gear rotatably associated with the output shaft. The system further includes a driven unit assembly including a driven gear configured to be attached to a wheel hub of the vehicle, and a brake disc coaxially attached to the driven gear. The drive gear may be configured to operably engage the driven gear to transmit power from the motor to the wheel hub. A brake caliper may be integrated with the drive unit assembly. The system may further include a battery and a speed controller configured to receive an input signal to selectively direct electrical power from the battery to the motor to drive the wheel via the drive gear and the driven gear.