Patents Assigned to BIND Biosciences, Inc.
-
Patent number: 8846077Abstract: This application provides a high throughput method of making nanoparticles that utilizes plates comprising wells (e.g., 96-well plates).Type: GrantFiled: December 17, 2012Date of Patent: September 30, 2014Assignee: Bind Biosciences, Inc.Inventor: David M. Dewitt
-
Patent number: 8734846Abstract: This application provides nanoparticles and methods of making nanoparticles using pre-functionalized poly(ethylene glycol)(also referred to as PEG) as a macroinitiator for the synthesis of diblock copolymers. Ring opening polymerization yields the desired poly(ester)-poly (ethylene glycol)-targeting agent polymer that is used to impart targeting capability to therapeutic nanoparticles. This “polymerization from” approach typically employs precursors of the targeting agent wherein the reactivity of functional groups of the targeting agent is masked using protecting groups. Also described is a “coupling to” that utilized the poly(ethylene glycol)-targeting agent conjugate where the targeting agent remains in its native un-protected form. This method uses “orthogonal” chemistry that exhibit no cross reactivity towards functional groups typically found within targeting agents of interest.Type: GrantFiled: November 2, 2012Date of Patent: May 27, 2014Assignee: Bind Biosciences, Inc.Inventors: Mir M. Ali, Jeff Hrkach, Stephen E. Zale, Luis Alvarez de Cienfuegos
-
Publication number: 20130243863Abstract: The present disclosure generally relates to lyophilized pharmaceutical compositions comprising polymeric nanoparticles which, upon reconstitution, have low levels of greater than 10 micron size particles. Other aspects of the invention include methods of making such nanoparticles.Type: ApplicationFiled: October 30, 2012Publication date: September 19, 2013Applicant: Bind Biosciences, Inc.Inventors: Greg Troiano, Young-Ho Song, Stephen E. Zale, James Wright, Christina Van Geen Hoven
-
Publication number: 20130236500Abstract: The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol. Other aspects of the invention include methods of making such nanoparticles.Type: ApplicationFiled: October 24, 2012Publication date: September 12, 2013Applicant: BIND BIOSCIENCES, INC.Inventors: Stephen E. Zale, Greg Troiano, Mir Mukkaram Ali, Jeff Hrkach, James Wright
-
Publication number: 20130123351Abstract: This application provides a high throughput method of making nanoparticles that utilizes plates comprising wells (e.g., 96-well plates).Type: ApplicationFiled: December 17, 2012Publication date: May 16, 2013Applicant: BIND BIOSCIENCES, INC.Inventor: BIND BIOSCIENCES, INC.
-
Publication number: 20130115192Abstract: This application provides nanoparticles and methods of making nanoparticles using pre-functionalized poly(ethylene glycol)(also referred to as PEG) as a macroinitiator for the synthesis of diblock copolymers. Ring opening polymerization yields the desired poly(ester)-poly(ethylene glycol)-targeting agent polymer that is used to impart targeting capability to therapeutic nanoparticles. This “polymerization from” approach typically employs precursors of the targeting agent wherein the reactivity of functional groups of the targeting agent is masked using protecting groups. Also described is a “coupling to” that utilized the poly(ethylene glycol)-targeting agent conjugate where the targeting agent remains in its native un-protected form. This method uses “orthogonal” chemistry that exhibit no cross reactivity towards functional groups typically found within targeting agents of interest.Type: ApplicationFiled: November 2, 2012Publication date: May 9, 2013Applicant: BIND BIOSCIENCES, INCInventor: BIND BIOSCIENCES, INC
-
Patent number: 8420123Abstract: The present disclosure generally relates to methods of making nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol.Type: GrantFiled: June 16, 2009Date of Patent: April 16, 2013Assignee: BIND Biosciences, Inc.Inventors: Greg Troiano, Michael Figa, Abhimanyu Sabnis
-
Patent number: 8357401Abstract: The present disclosure generally relates to lyophilized pharmaceutical compositions comprising polymeric nanoparticles which, upon reconstitution, have low levels of greater than 10 micron size particles. Other aspects of the invention include methods of making such nanoparticles.Type: GrantFiled: December 10, 2010Date of Patent: January 22, 2013Assignee: BIND Biosciences, Inc.Inventors: Greg Troiano, Young-Ho Song, Stephen E. Zale, James Wright, Christina Van Geen Hoven
-
Patent number: 8318208Abstract: The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol. Other aspects of the invention include methods of making such nanoparticles.Type: GrantFiled: July 19, 2012Date of Patent: November 27, 2012Assignee: Bind Biosciences, Inc.Inventors: Stephen E. Zale, Greg Troiano, Mir Mukkaram Ali, Jeff Hrkach, James Wright
-
Patent number: 8318211Abstract: The present disclosure generally relates to therapeutic nanoparticles. Exemplary nanoparticles disclosed herein may include about 1 to about 20 weight percent of a vinca alkaloid; and about 50 to about 99 weight percent biocompatible polymer.Type: GrantFiled: June 16, 2009Date of Patent: November 27, 2012Assignee: Bind Biosciences, Inc.Inventors: Stephen E. Zale, Greg Troiano, Mir Mukkaram Ali, Jeff Hrkach, James Wright
-
Patent number: 8293276Abstract: The present disclosure generally relates to methods of making nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic)acid-poly(ethylene)glycol.Type: GrantFiled: May 17, 2011Date of Patent: October 23, 2012Assignee: Bind Biosciences, Inc.Inventors: Greg Troiano, Michael Figa, Abhimanyu Sabnis
-
Patent number: 8273363Abstract: The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.Type: GrantFiled: May 17, 2011Date of Patent: September 25, 2012Assignee: Bind Biosciences, Inc.Inventors: Stephen E. Zale, Mir Mukkaram Ali
-
Patent number: 8246968Abstract: The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.Type: GrantFiled: March 31, 2008Date of Patent: August 21, 2012Assignee: Bind Biosciences, Inc.Inventors: Stephen E. Zale, Mir Mukkaram Ali
-
Patent number: 8236330Abstract: The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.Type: GrantFiled: May 17, 2011Date of Patent: August 7, 2012Assignee: Bind Biosciences, Inc.Inventors: Stephen E. Zale, Mir Mukkaram Ali
-
Patent number: 8211473Abstract: The present disclosure generally relates to lyophilized pharmaceutical compositions comprising polymeric nanoparticles which, upon reconstitution, have low levels of greater than 10 micron size particles. Other aspects of the invention include methods of making such nanoparticles.Type: GrantFiled: October 5, 2011Date of Patent: July 3, 2012Assignee: BIND Biosciences, Inc.Inventors: Greg Troiano, Young-Ho Song, Stephen E. Zale, James Wright, Christina Van Geen Hoven
-
Patent number: 8206747Abstract: The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol. Other aspects of the invention include methods of making such nanoparticles.Type: GrantFiled: June 16, 2009Date of Patent: June 26, 2012Assignee: BIND Biosciences, Inc.Inventors: Stephen E. Zale, Greg Troiano, Mir Mukkaram Ali, Jeff Hrkach, James Wright
-
Publication number: 20100266642Abstract: This application provides methods of making modified cells containing pre-functionalized poly(ethylene glycol) (PEG) and/or other pre-functionalized polymers are provided. The modified cells produced according to the disclosed methods as well as their use in the treatment of various diseases are also provided.Type: ApplicationFiled: February 18, 2010Publication date: October 21, 2010Applicant: BIND BIOSCIENCES, INC.Inventors: Susan Langer, Jeff Hrkach
-
Publication number: 20100104645Abstract: This application provides methods of making nanoparticles using pre-functionalized poly(ethylene glycol) (also referred to as PEG) as a macroinitiator for the synthesis of diblock copolymers. These diblock copolymers comprise a poly(ethylene glycol) block bearing a targeting agent at its terminus and a second biocompatible and biodegradable hydrophobic polymer block (e.g. a poly(ester)). The poly(ethylene glycol) is hetero-bifunctional with a targeting moiety (agent) covalently bound to its ? terminus and a polymerization initiating functional group (e.g., a hydroxyl group) present on its ? terminus. Ring opening polymerization yields the desired poly(ester)-poly(ethylene glycol)-targeting agent polymer that is used to impart targeting capability to therapeutic nanoparticles. This “polymerization from” approach typically employs precursors of the targeting agent wherein the reactivity of functional groups of the targeting agent is masked using protecting groups.Type: ApplicationFiled: June 16, 2009Publication date: April 29, 2010Applicant: BIND BIOSCIENCES, INC.Inventors: Mir M. Ali, Jeff Hrkach, Stephen E. Zale
-
Publication number: 20100087337Abstract: This application provides a high throughput method of making nanoparticles is provided that utilizes plates comprising wells (e.g., 96-well plates).Type: ApplicationFiled: September 10, 2009Publication date: April 8, 2010Applicant: BIND BIOSCIENCES, INC.Inventor: David M. Dewitt