Patents Assigned to Bio-Cancer Treatment International Limited
  • Methods and compositions for modulating the immune system with arginase I
    Patent number: 10532086
    Abstract: Methods and compositions comprising recombinant Arginase I proteins which are capable of depleting the plasma arginine levels in a subject are disclosed. The methods and compositions can be used to modulate the activity of the immune system in a subject. Modulation of the immune system is useful in the treatment of immune disorders and in preventing rejection of a transplanted organ, tissue, or cell. The methods and compositions can also be used to treat a bone condition of a subject.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: January 14, 2020
    Assignee: BIO-CANCER TREATMENT INTERNATIONAL LIMITED
    Inventors: Gernot Schabbauer, Stephan Bluml, Emine Sahin-Heco, Paul Cheng, Li Chen
  • Methods and compositions for modulating the immune system with Arginase I
    Patent number: 9867875
    Abstract: Methods and compositions comprising recombinant Arginase I proteins which are capable of depleting the plasma arginine levels in a subject are disclosed. The methods and compositions can be used to modulate the activity of the immune system in a subject. Modulation of the immune system is useful in the treatment of immune disorders and in preventing rejection of a transplanted organ, tissue, or cell. The methods and compositions can also be used to treat a bone condition of a subject.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: January 16, 2018
    Assignee: BIO-CANCER TREATMENT INTERNATIONAL LIMITED
    Inventors: Gernot Schabbauer, Stephen Bluml, Emine Sahin-Heco, Paul Cheng, Li Chen
  • Methods and compositions for modulating the immune system with arginase I
    Patent number: 9789169
    Abstract: Methods and compositions comprising recombinant Arginase I proteins which are capable of depleting the plasma arginine levels in a subject are disclosed. The methods and compositions can be used to modulate the activity of the immune system in a subject. Modulation of the immune system is useful in the treatment of immune disorders and in preventing rejection of a transplanted organ, tissue, or cell. The methods and compositions can also be used to treat a bone condition of a subject.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: October 17, 2017
    Assignee: Bio-Cancer Treatment International Limited
    Inventors: Gernot Schabbauer, Stephen Bluml, Emine Sahin-Heco, Paul Cheng, Li Chen
  • Pharmaceutical preparation and method of treatment of human malignancies with arginine deprivation
    Patent number: 8679810
    Abstract: The present invention provides an isolated and substantially purified recombinant human arginase having sufficiently high enzymatic activity and stability to maintain Adequate Arginine Depletion in a patient. The present invention also provides a pharmaceutical composition comprising the modified invention enzyme and method for treatment of diseases using the pharmaceutical composition.
    Type: Grant
    Filed: February 12, 2007
    Date of Patent: March 25, 2014
    Assignee: Bio-Cancer Treatment International Limited
    Inventors: Ning Man Cheng, Yun Chung Leung, Wai Hung Lo
  • Pharmaceutical preparation and method of treatment of human malignancies with arginine deprivation
    Patent number: 7951366
    Abstract: The present invention provides an isolated and substantially purified recombinant human arginase having sufficiently high enzymatic activity and stability to maintain Adequate Arginine Depletion in a patient. The present invention also provides a pharmaceutical composition comprising the modified invention enzyme and method for treatment of diseases using the pharmaceutical composition.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: May 31, 2011
    Assignee: Bio-Cancer Treatment International Limited
    Inventors: Ning Man Cheng, Yun Chung Leung, Wai Hung Lo
  • EXPRESSION SYSTEM FOR RECOMBINANT HUMAN ARGINASE I
    Publication number: 20100041101
    Abstract: A novel recombinant protein expression system is provided for improving expression of recombinant human arginase I. The system contains an isolated and purified nucleic acid molecule for constructing plasmid and E. coli strain in order to improve the expression of recombinant human arginase I. In another aspect of the present invention, a method is provided for producing an isolated E. coli strain in expressing said arginase.
    Type: Application
    Filed: November 20, 2007
    Publication date: February 18, 2010
    Applicant: BIO-CANCER TREATMENT INTERNATIONAL LIMITED
    Inventors: Yu Liang Huang, Zhong Shu Xian