Abstract: The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the inhibition of the activation of macrophages. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by activation of macrophages including infections, allograft reactions, inflammation, allergic and autoimmune diseases, metabolic disease, cardiovascular disease, tissue injury, and cancer.
Type:
Application
Filed:
February 18, 2010
Publication date:
January 5, 2012
Applicants:
Glaxo Group Ltd., Bio-Focus DPI B.V.
Inventors:
Richard Antonius Jozef Janssen, Anton De Groot, Annemarie Nicolette Lekkerkerker, Eric Charles Meldrum, Nicola Thompson, Marion Catherine Dickson, Keith Paul Ray, Susan Heather Boyce