Patents Assigned to Bio Holding, Inc.
  • Methods For Treating Arthritis, Autoimmune Disease, and Ischemia-Reperfusion Injury
    Publication number: 20110319330
    Abstract: The instant invention provides a method of treating an animal suffering a disease characterized by excessive apoptosis by administering a therapeutically effective amount of at least one serine protease inhibitor and thereafter monitoring a decrease in apoptosis. The inhibitor of the invention includes ?1-antitrypsin or an ?1-antitrypsin-like agent, including, but not limited to oxidation-resistant variants of ?1-antitrypsin, and peptoids with antitrypsin activity. The diseases treatable by the invention include cancer, autoimmune disease, sepsis neurodegenerative disease, myocardial infarction, stroke, ischemia-reperfusion injury, toxin induced liver injury and AIDS. The method of the invention is also suitable for the prevention or amelioration of diseases characterized by excessive apoptosis.
    Type: Application
    Filed: April 27, 2010
    Publication date: December 29, 2011
    Applicant: BIO HOLDING, INC.
    Inventor: LeLand Shapiro
  • HSP90 INHIBITORS AND METHODS OF USE
    Publication number: 20110201587
    Abstract: The present invention provides methods for treating various clinical conditions associated with biological activity of HSP90 in a subject. Such methods include administering to the subject in need of such a treatment a therapeutically effective amount of a composition comprising an HSP90 inhibitor.
    Type: Application
    Filed: February 16, 2010
    Publication date: August 18, 2011
    Applicant: BIO HOLDING, INC.
    Inventor: Leland Shapiro
  • Methods and compositions for inhibiting apoptosis using serine protease inhibitors
    Patent number: 7704958
    Abstract: The instant invention provides a method of treating an animal suffering a disease characterized by excessive apoptosis by administering a therapeutically effective amount of at least one serine protease inhibitor and thereafter monitoring a decrease in apoptosis. The inhibitor of the invention includes ?1-antitrypsin or an ?1-antitrypsin-like agent, including, but not limited to oxidation-resistant variants of ?1-antitrypsin, and peptoids with antitrypsin activity. The diseases treatable by the invention include cancer, autoimmune disease, sepsis neurodegenerative disease, myocardial infarction, stroke, ischemia-reperfusion injury, toxin induced liver injury and AIDS. The method of the invention is also suitable for the prevention or amelioration of diseases characterized by excessive apoptosis.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: April 27, 2010
    Assignee: Bio Holding, Inc.
    Inventor: Leland Shapiro
  • Methods and Compositions For Treatment of Nitric Oxide-Induced Clinical Conditions
    Publication number: 20090298747
    Abstract: The present invention provides compositions and methods for modulating cellular nitric oxide (NO) production and for treating a clinical condition associated therewith.
    Type: Application
    Filed: April 21, 2009
    Publication date: December 3, 2009
    Applicant: Bio Holding, Inc.
    Inventor: Leland Shapiro