Patents Assigned to Biolab Ltd
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Publication number: 20180043036Abstract: Provided are modified lipid compounds and their use in the formation of lipid assemblies. Also provided are lipid assemblies including (a) an amphoteric lipid including in covalent association with (i) one or more acyl chains; (ii) one or more weak base moiety; (iii) one or more weak acid moiety; the lipid assembly also including (b) one or more additional lipids, at least one of which being a zwitterionic lipid. In some embodiments, the amphoteric lipid is a compound including (a) a tri-functional moiety; (b) two non-phosphate lipid chains associated with two of the functional moieties of said tri-functional moiety; (c) optionally a spacer moiety associated with the third of the functional moieties of said tri-functional moiety; and (d) a polyalkylamine optionally including a short peptide with one to several carboxylic acid residues. Further provided are the uses of the lipid assembly, inter alia, for transfection or cancer treatment.Type: ApplicationFiled: February 4, 2016Publication date: February 15, 2018Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., QBI Enterprises Ltd., Rosetta Genomics, Biolab Ltd.Inventors: Sharon AVKIN-NACHUM, Tirtsa KLEINMAN, Noga YERUSHALMI, Yechezkel BARENHOLZ, Rivka COHEN, Kirill MAKEDONSKI, Eylon YAVIN, Andreas Ingemann JENSEN, Keren TURJEMAN
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Patent number: 8673285Abstract: The present invention concerns the use of a sphingoid-polyalkylamine conjugate as a capturing agent of biologically active molecules, such as antigens. In a particular embodiment, the spinogid-polyalkylamines are used for the preparation of pharmaceutical composition for modulating the immune response of a subject. Other aspects of the invention concern methods for modulating the immune response of a subject by the use of the conjugate, complexes comprising, the sphingoid-polyalkylamine conjugate in combination with a biologically active molecule capable of modulating an immune response of a subject, compositions comprising the conjugate as well as kits making use of said conjugate. A preferred conjugate according to the invention is N palmitoyl D-erythro sphingosyl 1 carbamoyl spermine.Type: GrantFiled: June 17, 2004Date of Patent: March 18, 2014Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Biolab Ltd.Inventors: Yechezkel Barenholz, Aviva Joseph, Eliezer Kedar
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Patent number: 7906122Abstract: The present invention concerns the use of a sphingoid-polyalkylamine conjugate as a capturing agent of biologically active molecules, such as antigens. In a particular embodiment, the spinogid-polyalkylamines are used for the preparation of pharmaceutical composition for stimulating or enhancing an immune response of a subject to protect against Hepatitis B Virus (HBV) infection. Other aspects of the invention concern methods for stimulating or enhancing an immune response of a subject to protect against Hepatitis B Virus (HBV) infection, by the use of the sphingoid-polyalkylamine conjugate, complexes comprising the sphingoid-polyalkylamine conjugate and a biologically active molecule, the latter, having an effect of stimulating or enhancing an immune response of a subject against to protect Hepatitis B Virus (HBV) infection, as well as kits making use of said conjugates and complexes. A preferred conjugate according to the invention is N-palmitoyl D-erythro sphingosyl-1-carbamoyl spermine (CCS).Type: GrantFiled: February 2, 2006Date of Patent: March 15, 2011Assignees: Yissum Research Development Company of the Hebrew University of Jersusalem, Biolab Ltd., Nasvax Ltd.Inventors: Yechezkel Bareholz, Eliezer Kedar, Sarit Samira
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Publication number: 20100305333Abstract: The present disclosure provides processes for the preparation of lipid conjugated cyclic carbonate derivatives. More specifically, the present disclosure is based on the finding that reacting lipids, such as, ceramides, with N,N?-disuccinimidyl derivative, resulted in the formation of, isolatable, substituted cyclic [1,3]-dioxan-2-one and [1,3]-dioxan-2-thione compounds. These isolatable cyclic substituted compounds and derivatives thereof may be used for various applications, such as in vaccination.Type: ApplicationFiled: May 11, 2008Publication date: December 2, 2010Applicants: BIOLAB LTD., NASVAX LTD., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEMInventors: Aaron Garzon, Jean Hildesheim
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Patent number: 7771711Abstract: The present invention concerns novel sphingolipid-polyalkylamines conjugates, a process for their preparation and pharmaceutical compositions comprising the same. In particular, the present invention concerns ceramide based polyalkylamine conjugates and its use as a capturing agent. A preferred ceramide polyalkylamine conjugate is a ceramide-spermine conjugate, more preferably, N-palmitoyl D-erythro sphingosyl-1-carbamoyl spermine.Type: GrantFiled: June 17, 2004Date of Patent: August 10, 2010Assignees: Yissum Research Development Company of The Hebrew University of Jerusalem, Biolab Ltd.Inventors: Yechezkel Barenholz, Dmitri Simberg, Elimelech Rochlin
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Patent number: 7687652Abstract: Novel cyclic and acyclic oxazaphospholanes are described, as well as their use in the synthesis of sphingomyelin and sphingomyelin analogous. The production of synthetic sphingomyelins is also described. 2S, 3R stereoisomers of oxazaphospholanes and sphingomyelins, and synthetic methods for their preparation are described.Type: GrantFiled: January 13, 2005Date of Patent: March 30, 2010Assignee: Biolab LtdInventors: Elimelech Rochlin, Jean Hildesheim, Alisa Berlin
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Publication number: 20080112917Abstract: The present invention concerns novel sphingolipid-polyalkylamines conjugates, a process for their preparation and pharmaceutical compositions comprising the same. In particular, the present invention concerns ceramide based polyalkylamine conjugates and its use as a capturing agent. A preferred ceramide polyalkylamine conjugate is a ceramide-spermine conjugate, more preferably, N-palmitoyl D-erythro sphingosyl-1-carbamoyl spermine.Type: ApplicationFiled: June 17, 2004Publication date: May 15, 2008Applicants: BIOLAB LTD., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEMInventors: Yechezkel Barenholz, Dmitri Simberg, Elimelech Rochlin
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Publication number: 20070264273Abstract: The present application discloses methods for stimulating or enhancing an immune response of a subject to protect against an infection caused by an agent selected from Hepatitis B Virus (HBV), avian influenza virus, the bacterium Bacillus anthracis or the bacterium Streptococcus pneumoniae, the method comprising administering to said subject a combination of sphingoid-polyalkylamine conjugate and a biologically active molecule, the combination being effective to provide said stimulation or enhancement of the immune response. Also disclosed are vaccines comprising a combination of the sphingoid-polyalkylamine conjugate and a biologically active molecule for stimulating or enhancing an immune response of a subject to protect against an infection caused by such an agent. Preferred conjugates are N-palmitoyl D-erythro sphingosyl-1-carbamoyl spermine (C-1 CCS), N-palmitoyl D-erythro sphingosyl-3-carbamoyl spermine (C-3 CCS) and mixtures thereof. Also disclosed are uses of C-3 CCS for various applications.Type: ApplicationFiled: May 9, 2007Publication date: November 15, 2007Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem, BioLab Ltd., NasVax Ltd.Inventors: Yechezkel BARENHOLZ, Eliezer Kedar, Sarit Samira
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Publication number: 20060171956Abstract: The present invention concerns the use of a sphingoid-polyalkylamine conjugate as a capturing agent of biologically active molecules, such as antigens. In a particular embodiment, the spinogid-polyalkylamines are used for the preparation of pharmaceutical composition for stimulating or enhancing an immune response of a subject to protect against Hepatitis B Virus (HBV) infection. Other aspects of the invention concern methods for stimulating or enhancing an immune response of a subject to protect against Hepatitis B Virus (HBV) infection, by the use of the sphingoid-polyalkylamine conjugate, complexes comprising the sphingoid-polyalkylamine conjugate and a biologically active molecule, the latter, having an effect of stimulating or enhancing an immune response of a subject against to protect Hepatitis B Virus (HBV) infection, as well as kits making use of said conjugates and complexes. A preferred conjugate according to the invention is N-palmitoyl D-erythro sphingosyl-1-carbamoyl spermine (CCS).Type: ApplicationFiled: February 2, 2006Publication date: August 3, 2006Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem, BIOLAB LTD., NasVax Ltd.Inventors: Yechezkel Bareholz, Eliezer Kedar, Sarit Samira