Patents Assigned to Bio-Layer Pty. Limited
-
Publication number: 20120214973Abstract: A method of immobilising a target molecule on a substrate, which comprises exposing the target molecule to the substrate in the presence of a metal complex, wherein the target molecule is an unmodified target molecule, and wherein the metal complex is selected to provide a stable binding interaction between the target molecule and the substrate.Type: ApplicationFiled: March 2, 2012Publication date: August 23, 2012Applicant: BIO-LAYER PTY LIMITEDInventors: Benjamin Ward MUIR, Michaael C. BARDEN, Dennis Brian RYLATT, N. Joe MAEJI, Carmel Judith HILLYARD, Alain-Dominique Jean-Pierre GORSE, Raisa Leonidovna MONTEIRO
-
Patent number: 8168445Abstract: A method of immobilizing a target molecule on a substrate, which comprises exposing the target molecule to the substrate in the presence of a metal complex, wherein the target molecule is an unmodified target molecule, and wherein the metal complex is selected to provide a stable binding interaction between the target molecule and the substrate.Type: GrantFiled: June 30, 2005Date of Patent: May 1, 2012Assignee: Bio-Layer Pty LimitedInventors: Benjamin Ward Muir, Michael C. Barden, Dennis Brian Rylatt, N. Joe Maeji, Carmel Judith Hillyard, Alain-Dominique Jean-Pierre Gorse, Raisa Leonidovna Monteiro
-
Patent number: 7881871Abstract: A method of producing a binding surface for a target molecule having a functional binding site, which method comprises: (i) identifying within the target molecule an anchor site which is remote from the functional binding site; (ii) generating a pharmacophore model for the anchor site; (iii) using the pharmacophore model to identify an anchor site binding ligand; and (iv) providing the anchor site binding ligand on a surface of a substrate such that the ability of the anchor site binding ligand to bind to the anchor site is preserved.Type: GrantFiled: December 10, 2004Date of Patent: February 1, 2011Assignee: Bio-Layer Pty LimitedInventor: Alain-Dominique Jean-Pierre Gorse
-
Publication number: 20090306342Abstract: A method of binding a target molecule from an analyte containing the target molecule in admixture with at least one non-target molecule, which method comprises exposing the analyte to a substrate comprising first and second surface binding components, wherein the first surface binding component has specific binding affinity with respect to the target molecule but is independently unable to provide effective binding of the target molecule to the substrate, wherein the second surface binding component has non-specific binding affinity with respect to the target molecule and is independently unable to provide effective specific binding of the target molecule to the substrate, and wherein the target molecule is immobilized on the substrate by the combined binding effect of the first and second surface binding components.Type: ApplicationFiled: December 29, 2006Publication date: December 10, 2009Applicant: BIO-LAYER PTY LIMITEDInventors: Joe Nobuyoshi Maeji, Alain-Dominique Jean-Pierre Gorse, Raisa Leonidovna Monteiro
-
Publication number: 20070099235Abstract: A method of producing a binding surface for a target molecule having a functional binding site, which method comprises: (i) identifying within the target molecule an anchor site which is remote from the functional binding site; (ii) generating a pharmacophore model for the anchor site; (iii) using the pharmacophore model to identify an anchor site binding ligand; and (iv) providing the anchor site binding ligand on a surface of a substrate such that the ability of the anchor site binding ligand to bind to the anchor site is preserved.Type: ApplicationFiled: December 10, 2004Publication date: May 3, 2007Applicant: Bio-Layer Pty LimitedInventor: Alain-Dominique Gorse
-
Patent number: 7144979Abstract: The present invention relates generally to a grafting process comprising the formation of a grafted polymeric structure having a substrate polymer in hybrid formation with one or more of the same or other polymers or monomeric subunits thereof. More particularly, the present invention contemplates a method of generating a homogenous or heterogenous grafted polymer by inducing or otherwise facilitating free radical formation to initiate polymerization of monomer units corresponding to the same or different polymers to a substrate polymer previously subjected to physical stress means. The resulting hybrid polymer may comprise a substrate polymer and a population of a second or further polymers in homogenous or heterogenous hybrid formation with the substrate polymer. A homogenous population includes a grafted population of the same polymer whereas a heterogenous population comprises a grafted population of two or more different polymers.Type: GrantFiled: December 19, 2001Date of Patent: December 5, 2006Assignee: Bio-Layer Pty. LimitedInventors: Nobuyoshi Joe Maeji, Geoffrey Wickham, Firas Rasoul