Abstract: Methods, compositions, and kits are provided for rapidly analyzing microbial growth and/or number in a plurality of water-in-oil emulsion droplets.

Abstract: A method of testing a biological sample, the method comprising: providing a centrifuge sample holder having a camera; arranging a transparent container comprising a fluid test medium in a recess of said centrifuge sample holder, wherein the camera is arranged to image a portion of the container comprising said fluid test medium; arranging said biological sample above and not in contact with said fluid test medium in said container; and with the camera, imaging a mixing of said biological sample with said fluid test medium while centrifuging the sample holder.

Abstract: Provided herein are methods and compositions for detecting Salmonella typhimurium in a sample.

Abstract: An apparatus for classifying a picture of a reaction of reactants in a predetermined container; the apparatus comprising a first neural network arranged for receiving an input picture of a reaction of reactants in a predetermined container and for providing, for each reaction category of a first plurality of reaction categories, a probability that the input picture shows a reaction that belongs to said reaction category; a second neural network arranged for, if the first neural response provides a highest probability that the input picture shows a reaction that belongs to a predetermined reaction category, receiving a predetermined portion of the input picture and providing, for each reaction category of a second plurality of reaction categories, a probability that said predetermined portion of the input picture shows a reaction that belongs to said reaction category.

Abstract: The present invention relates to the use of a control marker for implementing analysis methods on spots, in particular in the context of multiplex analyses. The present invention thus relates to solid supports containing said control marker, their preparation method and their use in analysis methods. The present invention makes it possible to verify the presence, location and/or integrity of the spots at the end of the analysis method, and thus to secure the obtained results while guaranteeing that the yielded result indeed results from a present, intact and localized spot.

Abstract: The present invention relates to a polypeptide carrying a human BNP(1-32) epitope according to Formula (I): a1-R1-X1-FGRKMDR-X2-R2-a2 as well as ligands specific of the FGRKMDR epitope.

Abstract: Methods, compositions, and kits are provided for rapidly analyzing microbial growth and/or number in a plurality of water-in-oil emulsion droplets.

Abstract: The present invention relates to the use of absorbent particles to improve the detection of a signal corresponding to the presence of an analyte in an analysis method on spot(s), in particular when the signal detection takes place in the presence of a liquid phase. The present invention also relates to an analysis method on spot(s) making it possible to improve the detection of a signal corresponding to the presence of an analyte, in the presence of a liquid phase comprising absorbent particles.

Abstract: The present invention concerns a method for the in vitro detection of an increased risk of diabetic nephropathy in a subject suffering from diabetes and being normoalbuminuric. Another aspect of the invention pertains to a method for the in vitro identification of a marker for prediction of diabetic nephropathy. Finally, the invention concerns a kit comprising means for detecting at least two proteins selected from the group consisting of heparan sulfate proteoglycan core protein or fragments thereof, carbonic anhydrase 1, prothrombin or fragments thereof, tetranectin, CD59 glycoprotein, plasma serine protease inhibitor, mannan-binding lectin serine protease 2 or isoforms thereof, antithrombin-III, alpha-1-antitrypsin, collagen alpha-1(I) chain, alpha-enolase, histone H2B type 1-O, glutaminyl-peptide cyclotransferase, protein AMBP and zinc-alpha-2-glycoprotein.

Abstract: The present invention relates to controls which may be used to secure the results of multiplex analysis methods. The present invention thus relates to solid supports comprising one or several controls and their use in multiplex analysis methods to detect several analytes potentially present in a sample.

Abstract: A pipette tip container comprising a pipette tip having a lumen extending between a proximal opening of a first diameter and a distal orifice of a second smaller diameter; a pellet arranged in the lumen of the pipette tip between said proximal opening and distal orifice, the second diameter being too narrow to let the pellet pass; and a retainer arranged between the pellet and the proximal opening and arranged to prevent the pellet from moving past the retainer in the lumen but to let fluid move past the retainer in the lumen; the retainer having a distal end such that a portion of its periphery does not contact the inner wall of the lumen, a proximal end such that a portion of its periphery maintains the retainer in the lumen by friction with the inner wall of the lumen; and a radial opening between the distal and proximal ends.

Abstract: The present invention relates to the use of a control marker for implementing analysis methods on spots, in particular in the context of multiplex analyses. The present invention thus relates to solid supports containing said control marker, their preparation method and their use in analysis methods. The present invention makes it possible to verify the presence, location and/or integrity of the spots at the end of the analysis method, and thus to secure the obtained results while guaranteeing that the yielded result indeed results from a present, intact and localized spot.

Abstract: A method of testing a biological sample, the method comprising: providing a centrifuge sample holder having a camera; arranging a transparent container comprising a fluid test medium in a recess of said centrifuge sample holder, wherein the camera is arranged to image a portion of the container comprising said fluid test medium; arranging said biological sample above and not in contact with said fluid test medium in said container; and with the camera, imaging a mixing of said biological sample with said fluid test medium while centrifuging the sample holder.

Abstract: Blood typing systems and methods are provided. In one embodiment, the method may be achieved by applying a sample to a surface of a substrate having one or more binding agents immobilized thereon, wherein the one or more binding agents are capable of binding to one or more substances in the sample; substantially removing unbound material from at least a portion of the substrate having immobilized binding agent; and detecting substances bound to the one or more binding agents immobilized on the substrate; wherein the applying the sample to the surface of the substrate step is concurrent with the removing unbound material from at least a portion of the substrate step. Systems and other methods are also described and illustrated.

Abstract: The use of at least one colorant is provided in order to improve the detection of a signal corresponding to the presence of an analyte in a dot analysis method, in particular when the detection of the signal takes place in the presence of a liquid phase. Also provided is a dot analysis method that can be used to improve the detection of a signal corresponding to the presence of an analyte, in the presence of a liquid phase containing at least one colorant.

Abstract: The present disclosure relates to a device for detecting an analyte in a sample, and especially for detecting antigen/antibody reactions, wherein said device comprises a layer composed of a low-density immiscible compound. The disclosure also relates to a method for detecting an analyte in a sample and especially for detecting antigen/antibody reactions in a device comprising a layer composed of a low-density immiscible compound. The disclosure further relates to the uses of such low-density immiscible compound.

Abstract: The present invention relates to a polypeptide carrying a human BNP(1-32) epitope according to Formula (I): a1-R1—X1—FGRKMDR—X2—R2-a2 as well as ligands specific of the FGRKMDR epitope.

Abstract: A pipette tip container comprising a pipette tip having a lumen extending between a proximal opening of a first diameter and a distal orifice of a second smaller diameter; a pellet arranged in the lumen of the pipette tip between said proximal opening and distal orifice, the second diameter being too narrow to let the pellet pass; and a retainer arranged between the pellet and the proximal opening and arranged to prevent the pellet from moving past the retainer in the lumen but to let fluid move past the retainer in the lumen; the retainer having a distal end such that a portion of its periphery does not contact the inner wall of the lumen, a proximal end such that a portion of its periphery maintains the retainer in the lumen by friction with the inner wall of the lumen; and a radial opening between the distal and proximal ends.

Abstract: The application concerns means for determining the stage of hepatic tissue damage, in particular the hepatic fibrosis score of subjects infected with one or more hepatitis viruses. In particular, the means of the invention involve measuring the levels of expression of selected genes, said selected genes being: SPP1, and at least one gene from among A2M and VIM, and at least one gene from among IL8, CXCL10 and ENG, and optionally, at least one gene from among the list of the following sixteen genes: IL6ST, p14ARF, MMP9, ANGPT2, CXCL11, MMP2, MMP7, S100A4, TIMP1, CHI3L1, COL1A1, CXCL1, CXCL6, IHH, IRF9 and MMP1.

Abstract: The invention relates to a station for uncovering a receptacle comprising a body in which a plurality of adjacent holes, initially sealed by a cover, are formed. The station comprises at least one cutting member for making at least one cut in the cover between two adjacent holes, so as to form at least one cover portion closing off at least one of the holes of the receptacle, i.e., the selected hole; and at least one heating gripping device which is arranged so as to heat and remove said cover portion, thereby opening the selected hole.