Patents Assigned to Bio-Technical Resources
  • Patent number: 7842497
    Abstract: The invention provides a biological method of producing isoprenoids.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: November 30, 2010
    Assignee: Bio-Technical Resources, a division of Arkion Life Sciences, LLC
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • Patent number: 7838279
    Abstract: The invention provides a biological method of producing isoprenoids.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: November 23, 2010
    Assignee: Bio-Technical Resources, a division of Arkion Life Sciences, LLC
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • Patent number: 7732161
    Abstract: The invention provides a biological method of producing isoprenoids.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: June 8, 2010
    Assignee: Bio-Technical Resources, a division of Arkion Life Sciences, LLC
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • Patent number: 7718417
    Abstract: The invention provides a biological method of producing isoprenoids.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: May 18, 2010
    Assignee: Bio-Technical Resources, a division of Arkion Life Sciences, LLC
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • Publication number: 20090017520
    Abstract: The present invention relates to a method and materials for producing glucosamine by fermentation of a genetically modified microorganism. Included in the present invention are genetically modified microorganisms useful in the present method for producing glucosamine, as well as recombinant nucleic acid molecules and the proteins produces by such recombinant nucleic acid molecules.
    Type: Application
    Filed: June 22, 2007
    Publication date: January 15, 2009
    Applicant: Arkion Life Sciences LLC d/b/a Bio-Technical Resources
    Inventors: Alan Berry, Richard P. Burlingame, James R. Millis
  • Publication number: 20060094085
    Abstract: The present invention relates to a method and materials for producing glucosamine by fermentation of a genetically modified microorganism. Included in the present invention are genetically modified microorganisms useful in the present method for producing glucsamine, as well as recombinant nucleic acid molecules and the proteins produces by such recombinant nucleic acid molecules.
    Type: Application
    Filed: October 5, 2005
    Publication date: May 4, 2006
    Applicant: Arkion Life Sciences LLC d/b/a Bio-Technical Resources
    Inventors: Alan Berry, Richard Burlingame, James Millis
  • Publication number: 20030125573
    Abstract: The invention provides a method of producing &agr;-tocopherol and &agr;-tocopheryl esters. The method comprises using a biological system to produce farnesol or geranylgeraniol. Then, the farnesol or geranylgernaiol is chemically converted into &agr;-tocopherol or an &agr;-tocopheryl ester.
    Type: Application
    Filed: July 9, 2001
    Publication date: July 3, 2003
    Applicant: DCV, Inc., d/b/a Bio-Technical Resources
    Inventors: James R. Millis, Gabriel G. Saucy, Julie Maurina-Brunker, Thomas W. McMullin
  • Publication number: 20030092144
    Abstract: The invention provides a biological method of producing farnesol or geranylgeraniol.
    Type: Application
    Filed: July 20, 2001
    Publication date: May 15, 2003
    Applicant: DCV, Inc. d/b/a Bio-Technical Resources.
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • Patent number: 5998329
    Abstract: The invention is directed to an unsintered spherical adsorbent particle composition having high mechanical strength and controlled pore size distribution, comprising finely divided silica hydrogel particles bonded together with a silica or metal oxide sol.
    Type: Grant
    Filed: June 30, 1997
    Date of Patent: December 7, 1999
    Assignee: Bio-Technical Resources
    Inventors: Mahlon Robert Derolf, Leonard Harris Smiley, Reinhard Herbert Witt
  • Patent number: 5902579
    Abstract: Natamycin biomass comprising 5-60% natamycin, most preferably 25-60% natamycin, and methods for forming the biomass, are disclosed. The natamycin biomass can be mixed with compatible carrier to form a premix comprising 0.2-5% natamycin. The premlix may be mixed with animal feed to form an animal feed mixture comprising cracked grain and 1.1-110 ppm of natamycin.
    Type: Grant
    Filed: April 29, 1996
    Date of Patent: May 11, 1999
    Assignee: Bio-Technical Resources
    Inventors: Michael Alan Eisenschink, James R. Millis, Phillip Terry Olson, Bruce Dexter King, Mary Ellen Rowland
  • Patent number: 5900370
    Abstract: The present invention is directed to methods for the production of ascorbic acid by culturing organisms of the genus Prototheca and recovering ascorbic acid from the fermentation medium.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 4, 1999
    Assignee: Bio-Technical Resources
    Inventor: Jeffrey Running
  • Patent number: 5753180
    Abstract: A non-biocidal method for inhibiting microbially influenced corrosion of susceptible metal surfaces having an anaerobic biofilm containing active sulfate-reducing bacteria comprising contacting the biofilm with a liquid dispersion of anthraquinone compound.
    Type: Grant
    Filed: August 9, 1996
    Date of Patent: May 19, 1998
    Assignee: Bio-Technical Resources
    Inventor: Edward Daniel Burger
  • Patent number: 5728898
    Abstract: Process for making water-soluble hydroquinone salts by reacting an aqueous liquid solution of (a) a formamidinesulfinic acid and (b) an alkali metal or quaternary ammonium hydroxide in which is dispersed a (c) quinone and water-soluble hydroquinone salts made thereby.
    Type: Grant
    Filed: June 27, 1996
    Date of Patent: March 17, 1998
    Assignee: Bio-Technical Resources, L.P.
    Inventor: Mark Harry Krackov
  • Patent number: 5648258
    Abstract: Anthraquinone compounds inhibit methane production by methanogenic bacteria in the rumen of ruminant animals, increasing production of volatile fatty acids and feed utilization efficiency. Preferred anthraquinones are unsubstituted anthraquinone, 1-aminoanthraquinone, 1-chloroanthraquinone, 2-chloroanthraquinone, 2-chloro-3-carboxyanthraquinone, 1-hydroxyanthraquinone, and 9,10-dihydroanthraquinone.
    Type: Grant
    Filed: July 24, 1995
    Date of Patent: July 15, 1997
    Assignee: Bio-Technical Resources
    Inventor: James Martin Odom
  • Patent number: 5612184
    Abstract: Devices for the detection of small quantities either of divalent inorganic mercury ion (Hg.sup.2+) or of both Hg.sup.2+ and monomethyl mercury in water are disclosed. These devices comprises a bioluminescence detecting means and a bioluminescent biosensory microorganism cells, that emit significant light only when exposed to either to Hg.sup.2+ or to Hg.sup.2+ or momomethyl mercury. Plasmid cassettes and host microorganisms containing such cassettes are also disclosed The plasmid cassettes comprises a lux gene operon complex from Xenorhabdus luminescens. The lux operon complex comprises luxC, luxD, luxA, luxB, and luxE genes but is free of (1) a promoter for the complex and (2) an inducible regulatory gene for the complex.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 18, 1997
    Assignee: Bio-Technical Resources L.P.
    Inventor: Reinhardt A. Rosson
  • Patent number: 5591438
    Abstract: A process for the recovery of high purity natamycin from fermentaion broth by extraction with methanol is disclosed. In one embodiment the process comprises the steps:(1) adding methanol to a natamycin feed stream comprising at least 2 g/L of solid suspended natamycin to form an extraction medium, and maintaining the extraction medium at a temperature of 0.degree.-25.degree. C., preferably not over 15.degree. C.;(2) adjusting the pH of the extraction medium to 1.0 to 4.5 while maintaining the temperature at 0.degree.-25.degree. C. for 0.5 to 30 hours, but preferably not over 0.5 hours when the temperature is 15.degree.-25.degree. C.;(3) removing solids from the extraction medium to form an extraction liquor;(4) raising the pH of the extraction liquor to 6.0-9.0; and(5) recovering precipitated natamycin.
    Type: Grant
    Filed: May 3, 1994
    Date of Patent: January 7, 1997
    Assignee: Bio-Technical Resources L.P.
    Inventors: Phillip T. Olson, James R. Millis, Michael H. Reimer
  • Patent number: 5571722
    Abstract: Devices for the detection of small quantities either of divalent inorganic mercury ion (Hg.sup.2+) or of both Hg.sup.2+ and monomethyl mercury in water are disclosed. These devices comprises a bioluminescence detecting means and a bioluminescent biosensory microorganism cells, that emit significant light only when exposed to either to Hg.sup.2+ or to Hg.sup.2+ or momomethyl mercury. Plasmid cassettes and host microorganisms containing such cassettes are also disclosed The plasmid cassettes comprises a lux gene operon complex from Xenorhabdus luminescens. The lux operon complex comprises luxC, luxD, luxA, luxB, and luxE genes but is free of (1) a promoter for the complex and (2) an inducible regulatory gene for the complex.
    Type: Grant
    Filed: August 23, 1993
    Date of Patent: November 5, 1996
    Assignee: Bio-Technical Resources L.P.
    Inventor: Reinhardt A. Rosson
  • Patent number: 5521090
    Abstract: Microalgal biomass that comprises cells of Chlorella pyrenoidosa which contain greater than 2.0% by dry weight of L-ascorbic acid (Vitamin C), microorganisms and processes that form the biomass, and L-ascorbic acid enhanced animal feed compositions that contain the biomass are disclosed.
    Type: Grant
    Filed: February 10, 1994
    Date of Patent: May 28, 1996
    Assignee: Bio-Technical Resources
    Inventors: James A. Doncheck, Ronald J. Huss, Jeffrey A. Running, Thomas J. Skatrud
  • Patent number: 5500368
    Abstract: A method of inhibit sulfide production in a media containing sulfate-reducing bacteria is disclosed. The method comprises adding particles of a finely divided sulfide production-inhibiting anthraquinone to the medium. The particles have a particle size of 0.1 to 2.5 microns, preferably 2 to 0.1 microns.
    Type: Grant
    Filed: October 21, 1994
    Date of Patent: March 19, 1996
    Assignee: Bio-Technical Resources
    Inventor: Robert E. Tatnall
  • Patent number: 5470728
    Abstract: Cis-dihydrodiol compounds of the formula ##STR1## where n is 0 or 1 (preferably 0) are produced by the microbial oxidation of a diphenylaceylene compound of the formula ##STR2## using a mutant of a Pseudomonas bacteria at 25.degree. to 35.degree. C. and pH 6-8. The cis-dihydrodiol compound is in turn treated with an aqueous solution of a base to produce a corresponding 3-hydroxydiphenylacetylene compound or with an aqueous solution of an acid to produce a corresponding 2-hydroxyacetylene compound. The mutant strain is preferably Pseudomonas ATCC 55272.
    Type: Grant
    Filed: August 8, 1994
    Date of Patent: November 28, 1995
    Assignee: Bio-Technical Resources
    Inventor: Alan D. Grund