Patents Assigned to Bioactives, Inc.
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Patent number: 8883225Abstract: The present invention is drawn to water-soluble compositions for providing hops constituents, particularly alpha acids, iso-alpha acids, and beta acids. A pharmaceutical gel composition can comprise a hops extract and a surfactant. Such compositions can be formulated into products for various therapeutic applications, including oral and topical uses. Such compositions can also be dissolved in water to yield a clear solution containing more dilute hops acids. The invention also provides methods of treatment comprising administering water-soluble hops compositions. The present invention is also drawn to methods for making water-soluble preparations of hops constituents.Type: GrantFiled: January 8, 2013Date of Patent: November 11, 2014Assignee: Bioactives, Inc.Inventor: Eric H. Kuhrts
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Publication number: 20140023599Abstract: The present invention is drawn to water-soluble compositions for providing hops constituents, particularly alpha acids, iso-alpha acids, and beta acids. A pharmaceutical gel composition can comprise a hops extract and a surfactant. Such compositions can be formulated into products for various therapeutic applications, including oral and topical uses. Such compositions can also be dissolved in water to yield a clear solution containing more dilute hops acids. The invention also provides methods of treatment comprising administering water-soluble hops compositions. The present invention is also drawn to methods for making water-soluble preparations of hops constituents.Type: ApplicationFiled: January 8, 2013Publication date: January 23, 2014Applicant: Bioactives, Inc.Inventor: Bioactives, Inc.
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Publication number: 20130123368Abstract: Methods of reducing 15-F2t-IsoP levels in mammalian subjects are disclosed herein. In addition, methods of reducing or preventing oxidative stress and treating or preventing related diseases are disclosed.Type: ApplicationFiled: December 28, 2012Publication date: May 16, 2013Applicant: BIOACTIVES, INC.Inventor: BIOACTIVES, INC.
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Patent number: 8349375Abstract: The present invention is drawn to water-soluble compositions for providing hops constituents, particularly alpha acids, iso-alpha acids, and beta acids. A pharmaceutical gel composition can comprise a hops extract and a surfactant. Such compositions can be formulated into products for various therapeutic applications, including oral and topical uses. Such compositions can also be dissolved in water to yield a clear solution containing more dilute hops acids. The invention also provides methods of treatment comprising administering water-soluble hops compositions. The present invention is also drawn to methods for making water-soluble preparations of hops constituents.Type: GrantFiled: December 5, 2011Date of Patent: January 8, 2013Assignee: Bioactives, Inc.Inventor: Eric H. Kuhrts
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Publication number: 20120059052Abstract: Methods and formulations for increasing the water solubility and/or bioavailability of prenylfiavonoids are disclosed. The formulations may be employed to treat a disease states, including cancer.Type: ApplicationFiled: November 9, 2011Publication date: March 8, 2012Applicant: BIOACTIVES, INC.Inventor: Eric Kuhrts
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Patent number: 8071136Abstract: The present invention is drawn to water-soluble compositions for providing hops constituents, particularly alpha acids, iso-alpha acids, and beta acids. A pharmaceutical gel composition can comprise a hops extract and a surfactant. Such compositions can be formulated into products for various therapeutic applications, including oral and topical uses. Such compositions can also be dissolved in water to yield a clear solution containing more dilute hops acids. The invention also provides methods of treatment comprising administering water-soluble hops compositions. The present invention is also drawn to methods for making water-soluble preparations of hops constituents.Type: GrantFiled: April 21, 2006Date of Patent: December 6, 2011Assignee: Bioactives, Inc.Inventor: Eric H. Kuhrts
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Publication number: 20110003888Abstract: Methods and mixtures for extracting prenylflavonoids from prenylflavonoid-containing hops materials are provided.Type: ApplicationFiled: January 14, 2008Publication date: January 6, 2011Applicant: Bioactives, Inc.Inventor: Eric Kuhrts
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Publication number: 20100330215Abstract: Disclosed are novel anti-inflammatory pharmaceutical compositions and related methods that exhibit potent and selective inhibition of the cycloooxygenase-2 (COX-2) enzyme. The formulation can comprise a hops extract that exhibits COX-2 selectivity as defined by dividing the IC50 COX-2/IC50COX-1 concentrations that are determined by testing with the William Harvey Whole Blood Assay (WHMA), and can fall within the range of 0.011 to 0.2. Such compositions may also optionally contain high levels of alpha acids and low levels of beta acids, some flavonoid compounds, and virtually no essential oils. Such compositions are useful for treating conditions that manifest as inflammatory pain, or are impacted by the COX-2 enzyme. The recited compositions are particularly beneficial for treating osteoarthritis and rheumatoid arthritis, and can be used for chronic pain with reduced gastric side-effects.Type: ApplicationFiled: September 1, 2010Publication date: December 30, 2010Applicant: Bioactives, Inc.Inventor: Eric Kuhrts
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Publication number: 20090227535Abstract: The present invention provides a process for producing ?-(3-(1,3/1,6)-D-glucan from a cellular source comprising the steps of alkali extraction of the cellular source; water extraction; acid extraction; and water extraction, where at least one step of water extraction includes pasteurization by steam injection to a temperature of about 100° C. for 15 to about 30 minutes. The solid component produced comprises at least ?-70% 1 (1,3/1,6)-D-glucan by dry weight. The present invention also provides a process of producing mannan and manno-protein complexes comprising the steps of collecting a liquid phase obtained in one an alkali extraction step of the ?(3-(1,3/1,6)-D-glucan process; adjusting the pH of the liquid phase to about 5.0-8.0 with an acid; pasteurizing the liquid phase by steam injection to a temperature of about 100° C. for 15 to about 30 minutes; and isolating the mannans and manno-proteins complexes from the pasteurized liquid phase.Type: ApplicationFiled: October 18, 2005Publication date: September 10, 2009Applicant: Progressive BioActives IncInventors: Philip Anthony Courie, JR., Shane Patelakis, Amy Jo Miles
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Publication number: 20070254962Abstract: Disclosed are novel anti-inflammatory pharmaceutical compositions and related methods that exhibit potent and selective inhibition of the cycloooxygenase-2 (COX-2) enzyme. The formulation can comprise a hops extract that exhibits COX-2 selectivity as defined by dividing the IC50 COX-2/IC50COX-1 concentrations that are determined by testing with the William Harvey Whole Blood Assay (WHMA), and can fall within the range of 0.011 to 0.2. Such compositions may also optionally contain high levels of alpha acids and low levels of beta acids, some flavonoid compounds, and virtually no essential oils. Such compositions are useful for treating conditions that manifest as inflammatory pain, or are impacted by the COX-2 enzyme. The recited compositions are particularly beneficial for treating osteoarthritis and rheumatoid arthritis, and can be used for chronic pain with reduced gastric side-effects.Type: ApplicationFiled: April 17, 2007Publication date: November 1, 2007Applicant: Bioactives, Inc.Inventor: Eric Kuhrts