Abstract: Processes that, make nitrogen-containing compounds include converting succinic acid (SA) or monoammonium succinate (MAS) derived from a diammoniurn succinate (DAS)- or MAS-containing fermentation broth to produce such compounds Including diammobmane (DAB), succinic dinitrile (SDN), succinic amino nitrile (SAN), succinamide (DAM), and related polymers.
Type:
Application
Filed:
August 30, 2011
Publication date:
May 15, 2014
Applicant:
BIOAMBER S.A.S.
Inventors:
Olan S. Fruchey, Leo E. Manzer, Dilum Dunuwila, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Bernard D. Dombek
Abstract: A method of removing color bodies from a fermentation broth includes precipitating a color-forming impurity (color body) by adjusting the fermentation broth to a pH greater than about 13; filtering our precipitated color-forming impurities from the broth; and bleaching a second color impurity by treating the broth with an oxidizing agent.
Abstract: Processes for making monoammonium succinate (MAS) and/or succinic acid (SA) from either a clarified diammonium succinate (DAS)-containing fermentation broth or a clarified MAS-containing fermentation broth include (a) distilling the broth to form an overhead that includes water and optionally ammonia and a liquid bottoms that includes MAS or SA; (b) cooling and/or evaporating the bottoms and optionally adding an antisolvent to the bottoms to attain a temperature and composition sufficient to cause the bottoms to produce a solid portion that contains MAS or SA in contact with a liquid portion; (c) separating the solid portion from the liquid portion; and (d) recovering the solid portion.
Type:
Grant
Filed:
March 18, 2011
Date of Patent:
January 7, 2014
Assignee:
BioAmber S.A.S.
Inventors:
Olan S. Fruchey, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Dilum Dunuwila, Bernard D. Dombek
Abstract: The present application provides genetically modified yeast cell comprising an active succinate fermentation pathway, as well as methods of using these cells to produce succinate.
Inventors:
Kenneth R. Finley, Jeanette M. Huryta, Beth M. Mastel, Thomas W. McMullin, Gregory M. Poynter, Brian J. Rush, Kevin T. Watts, Arlene M. Fosmer, Vernon L. McIntosh, JR., Keith M. Brady
Abstract: Processes for making pyrrolidones include providing a clarified diammonium succinate (DAS)-containing and/or monoammonium succinate (MAS)-containing fermentation broth; distilling the broth under super atmospheric pressure at a temperature of greater than 100° C. to about 300° C. to form an overhead that includes water and ammonia, and a liquid bottoms that includes SA, and at least about 20 wt % water; cooling and/or evaporating the bottoms to attain a temperature and composition sufficient to cause the bottoms to separate into a liquid portion and a solid portion that is substantially pure SA; separating the solid portion from the liquid portion; and converting the solid SA portion to pyrrolidones.
Type:
Application
Filed:
May 17, 2011
Publication date:
July 11, 2013
Applicant:
BIOAMBER S.A.S.
Inventors:
Olan S. Fruchey, Leo E. Manzer, Dilum Dunuwila, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Bernard D. Dombek
Abstract: Processes that make nitrogen-containing compounds include converting succinic acid (SA) or monoammonium succinate (MAS) derived from a diammonium succinate (DAS)- or MAS-containing fermentation broth to produce such compounds including diaminobutane (DAB), succinic dinitrile (SDN), succinic amino nitrile (SAN), succinamide (DAM), and related polymers.
Type:
Application
Filed:
May 18, 2011
Publication date:
July 4, 2013
Applicant:
BIOAMBER S.A.S.
Inventors:
Olan S. Fruchey, Leo E. Manzer, Dilum Dunuwila, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Bernard D. Dombek
Abstract: A process for making a hydrogenated product comprising caprolactone (CLO) and 1,6-hexanediol (HDO) and derivatives thereof from adipic acid (AA) obtained from fermentation broths containing diammonium adipate (DAA) or monoammonium adipate (MAA).
Type:
Application
Filed:
June 10, 2011
Publication date:
June 20, 2013
Applicant:
BIOAMBER S.A.S.
Inventors:
Olan S. Fruchey, Leo E. Manzer, Dilum Dunuwila, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Bernard D. Dombek
Abstract: Processes for removing color bodies from crude succinic acid comprising distillation of crude succinic acid and collecting the distillate in a water-containing receiver. The color bodies substantially remain in the distillation bottoms and the purified succinic acid in the water-containing receiver is substantially free of color bodies.
Abstract: Processes for making hydrogenated products including caprolactame (CL) caprolactone (CLO) or 1,6-hexanediol (HDO) and derivative thereof from monoammonium adipate (MAA) and/or adipic acid (AA) obtained from a clarified diammonium adipate-containing (DAA-containing) fermentation broth or monoammonium adipate-containing (MAA-containing) fermentation broth.
Type:
Application
Filed:
June 10, 2011
Publication date:
June 13, 2013
Applicant:
BIOAMBER S.A.S.
Inventors:
Olan S. Fruchey, Leo E. Manzer, Dilum Dunuwila, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Bernard D. Dombek
Abstract: A process for making a NH4+OOC—R—COOH compound from a clarified NH4+OOC—R—COO?NH4+ compound-containing fermentation broth includes (a) distilling the broth to form an overhead that includes water and ammonia, and a liquid bottoms that includes a NH4+OOC˜R˜COOH compound, at least some of a NH4+QOC—R—COO?NH4+ compound, and at least about 20 wt % water; (b) cooling the bottoms to a temperature sufficient to cause the bottoms to separate into a NH4+OOC—R˜C00?NH4+ compound-containing liquid portion in contact with a NH4+OOC—R—COOH compound-containing solid portion that is substantially free of the NH4+OOC—R—COO?NH4+ compound; (c) separating the solid portion from the liquid portion; and (d) recovering the solid portion.
Type:
Application
Filed:
April 15, 2011
Publication date:
June 6, 2013
Applicant:
BIOAMBER S.A.S.
Inventors:
Olan S. Fruchey, Leo E. Manzer, Dilum Dunuwila, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Bernard D. Dombek
Abstract: Processes for making pyrrolidones include making MAS and/or SA from a clarified DAS- and/or MAS-containing fermentation broth and converting the MAS or SA to the pyrrolidones, typically with catalysts at selected temperatures and pressures.
Type:
Application
Filed:
May 18, 2011
Publication date:
June 6, 2013
Applicant:
BIOAMBER S.A.S.
Inventors:
Olan S. Fruchey, Leo E. Manzer, Dilum Dunuwila, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Bernard D. Dombek
Abstract: Processes for producing caprolactam (CL) and derivatives thereof from adipic acid (AA) obtained from fermentation broths containing diammonium adipate (DAA) or monoammonium adipate (MAA).
Type:
Application
Filed:
June 10, 2011
Publication date:
May 23, 2013
Applicant:
BIOAMBER S.A.S.
Inventors:
Olan S. Fruchey, Leo E. Manzer, Dilum Dunuwila, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Bernard D. Dombek
Abstract: Processes for making caprolactam (CL) from monoammonium adipate (MAA) and/or adipic aicd (AA) obtained from a clarified diammonium adipate-containing (DAA-containing) fermentation broth or MAA-containing fermentation broth and converting the MAA or AA to the CL with hydrogen in the presence of a catalyst at selected temperatures and pressures.
Type:
Application
Filed:
June 10, 2011
Publication date:
May 9, 2013
Applicant:
BIOAMBER S.A.S.
Inventors:
Olan S. Fruchey, Leo E. Manzer, Dilum Dunuwila, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Bernard D. Dombek
Abstract: Processes for making SA from either a clarified DAS-containing fermentation broth or a clarified MAS-containing fermentation broth that include distilling the broth under super atmospheric pressure at a temperature of >100° C. to about 300° C. to form an overhead that comprises water and ammonia, and a liquid bottoms that includes SA, and at least about 20 wt % water; cooling the bottoms to a temperature sufficient to cause the bottoms to separate into a liquid portion and a solid portion that is substantially pure SA; and separating the solid portion from the liquid portion. A method also reduces the broth distillation temperature and pressure by adding an ammonia separating and/or water azeotroping solvent to the broth.
Type:
Grant
Filed:
August 19, 2011
Date of Patent:
August 21, 2012
Assignee:
BioAmber S.A.S.
Inventors:
Olan S. Fruchey, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Dilum Dunuwila, Bernard D. Dombek
Abstract: Processes for making monoammonium succinate (MAS) and/or succinic acid (SA) from either a clarified diammonium succinate (DAS)-containing fermentation broth or a clarified MAS-containing fermentation broth include (a) distilling the broth to form an overhead that includes water and optionally ammonia and a liquid bottoms that includes MAS or SA; (b) cooling and/or evaporating the bottoms and optionally adding an antisolvent to the bottoms to attain a temperature and composition sufficient to cause the bottoms to produce a solid portion that contains MAS or SA in contact with a liquid portion; (c) separating the solid portion from the liquid portion; and (d) recovering the solid portion.
Type:
Grant
Filed:
August 17, 2011
Date of Patent:
June 19, 2012
Assignee:
BioAmber S.A.S.
Inventors:
Olan S. Fruchey, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Dilum Dunuwila, Bernard D. Dombek
Abstract: Processes for making SA from either a clarified DAS-containing fermentation broth or a clarified MAS-containing fermentation broth that include distilling the broth under super atmospheric pressure at a temperature of >100° C. to about 300° C. to form an overhead that comprises water and ammonia, and a liquid bottoms that includes SA, and at least about 20 wt % water; cooling the bottoms to a temperature sufficient to cause the bottoms to separate into a liquid portion and a solid portion that is substantially pure SA; and separating the solid portion from the liquid portion. A method also reduces the broth distillation temperature and pressure by adding an ammonia separating and/or water azeotroping solvent to the broth.
Type:
Application
Filed:
September 16, 2011
Publication date:
January 26, 2012
Applicant:
BIOAMBER S.A.S.
Inventors:
Olan S. Fruchey, Brian T. Keen, Brooke A. Albin, Bernard D. Dombek, Nye A. Clinton, Paul R. Zitzelsberger, Matthew B. Brumley
Abstract: A process for making a hydrogenated product includes providing a clarified DAS-containing fermentation broth; distilling the broth under super atmospheric pressure at a temperature of >100° C. to about 300° C. to form an overhead that includes water and ammonia, and a liquid bottoms that includes SA, and at least about 20 wt % water; cooling the bottoms to a temperature sufficient to cause the bottoms to separate into a liquid portion in contact with a solid portion that is substantially pure SA; separating the solid portion from the liquid portion; recovering the solid portion; hydrogenating the solid portion in the presence of at least one hydrogenation catalyst to produce the hydrogenated product including at least one of THF, GBL or BDO; and recovering the hydrogenated product.
Type:
Grant
Filed:
August 19, 2011
Date of Patent:
December 27, 2011
Assignee:
BioAmber S.A.S.
Inventors:
Olan S. Fruchey, Leo E. Manzer, Dilum Dunuwila, Brian Terry Keen, Brooke Ashley Albin, Nye A. Clinton, Bernard Duane Dombek
Abstract: A process for making a hydrogenated product includes providing a clarified DAS-containing fermentation broth; distilling the broth under super atmospheric pressure at a temperature of >100° C. to about 300° C. to form an overhead that includes water and ammonia, and a liquid bottoms that includes SA, and at least about 20 wt % water; cooling the bottoms to a temperature sufficient to cause the bottoms to separate into a liquid portion in contact with a solid portion that is substantially pure SA; separating the solid portion from the liquid portion; recovering the solid portion; hydrogenating the solid portion in the presence of at least one hydrogenation catalyst to produce the hydrogenated product including at least one of THF, GBL or BDO; and recovering the hydrogenated product.
Type:
Application
Filed:
August 19, 2011
Publication date:
December 15, 2011
Applicant:
BioAmber S.A.S.
Inventors:
Olan S. Fruchey, Leo E. Manzer, Dilum Dunuwila, Brian Terry Keen, Brooke Ashley Albin, Nye A. Clinton, Bernard Duane Dombek