Abstract: The invention relates to substitution derivatives of N6-benzyladenosine-5?-monophosphate of the general formula I, wherein (R)n represents 1 to 4 substituents (n is in the range 1-4), which can be the same or different, and R is selected from the group comprising C1 to C8 alkyl, C1 to C8 alkoxy, amino, halogen, hydroxy, mercapto and nitro groups, and the pharmaceutically acceptable salts thereof. This invention also relates to methods of their preparation, their use as medicaments and in other biotechnological applications, and a therapeutic composition containing these derivatives.
Type:
Grant
Filed:
April 28, 2011
Date of Patent:
July 7, 2015
Assignees:
UNIVERZITA PALACKEHO V OLOMOUCI, BIOAPEX, S.R.O.
Inventors:
Marek Zatloukal, Karel Dolezal, Jiri Voller, Lukas Spichal, Miroslav Strnad
Abstract: This invention relates to novel saponin compounds of formula II wherein MBz denotes p-methoxybenzoyl, and R is selected from the group comprising C6-10 aryl, C6-10 aryl-C1-4 alkyl-, C1-18 alkanoyl, C3-18 alkenyl, C6-10 aryl-C(O)—, C6-10 aryl-C1-4 alkyl-C(O)—, wherein each of the groups can optionally be substituted. These compounds possess a selective cytostatic activity, useful, e.g., in the treatment of proliferative diseases. The invention further relates to methods of preparation of the novel compounds and to a pharmaceutical composition containing these compounds.
Type:
Grant
Filed:
February 8, 2010
Date of Patent:
October 8, 2013
Assignees:
Uniwersytet W Bialymstoku, Univerzita Palackeho V Olomouci, Bioapex, S.R.O.
Inventors:
Jacek Witold Morzycki, Agnieszka Wojtkielewicz, Jana Oklestkova, Lucie Hoffmannova, Miroslav Strnad
Abstract: Substitution derivatives of N6-benzyladenosine-5?-monophosphate of the general formula I, wherein (R)n represents 1 to 4 substituents (n is in the range 1-4), which can be the same or different, and R is selected from the group comprising C1 to C8 alkyl, C1 to C8 alkoxy, amino, halogen, hydroxy, mercapto and nitro groups, and the pharmaceutically acceptable salts thereof. A Method for their preparation, their use as medicaments and in other applications, and a therapeutic composition containing these derivatives is also disclosed.
Type:
Application
Filed:
April 28, 2011
Publication date:
February 14, 2013
Applicants:
BIOAPEX, S.R.O., UNIVERZITA PALACKEHO V OLOMOUCI
Inventors:
Marek Zatloukal, Karel Dolezal, Jiri Voller, Lukas Spichal, Miroslav Strnad