Patents Assigned to BIOAPPLICATIONS INC.
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Patent number: 11958883Abstract: The present invention provides a recombinant expression vector comprising a gene encoding canine parvovirus 2a VP2 or 2b VP2 protein, a recombinant plant into which the vector is transformed, a vaccine composition against canine parvovirus, comprising canine parvovirus 2a VP2 or 2b VP2 protein obtained from the recombinant plant, and a composition for diagnosing canine parvovirus. When the recombinant plant of the present invention is used, canine parvovirus 2a VP2 or 2b VP2 antigen protein can be rapidly produced with high efficiency. Since the composition for diagnosing canine parvovirus according to the present invention uses a recombinant antigen protein, there is no possibility of contamination due to live virus handling, and thus the composition is safe, and the presence or absence of canine parvovirus infection can be rapidly diagnosed from a large amount of samples.Type: GrantFiled: April 17, 2020Date of Patent: April 16, 2024Assignees: REPUBLIC OF KOREA(ANIMAL AND PLANT QUARANTINE AGENCY), BIOAPPLICATIONS INC.Inventors: In-Ohk Ouh, Jae-Young Song, Ju-Yeon Lee, Soo Dong Cho, Jienny Lee, Yongjik Lee
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Patent number: 11845945Abstract: Provided is a technique for highly expressing a target protein in a plant cell by using a glycosylation domain, a recombinant vector comprising a gene encoding a fusion protein of a glycosylation domain and a target protein, a recombinant cell, a transformed plant, and a method of producing a target protein using these.Type: GrantFiled: February 14, 2022Date of Patent: December 19, 2023Assignee: BIOAPPLICATIONS INC.Inventors: In Hwan Hwang, Hyang Ju Kang
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Publication number: 20230203101Abstract: The present invention relates to a recombinant spike protein of the COVID-19 virus forming a trimer and a method for mass-producing the recombinant spike protein, and more specifically to a method for designing a recombinant gene expressing a recombinant spike protein of the COVID-19 virus forming a trimer for the purposes of enhancing immunogenicity and effective antigen delivery, and a method for mass-producing the recombinant spike protein in plants.Type: ApplicationFiled: April 22, 2021Publication date: June 29, 2023Applicants: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION, KOREA NATIONAL INSTITUTE OF HEALTH, BIOAPPLICATIONS INCInventors: In Hwan HWANG, Shijian SONG, Rezaul Islam Khan MD, Haiping DIAO, Eun Ju SOHN, Bo Hwa CHOI, Jang Hoon CHOI, Eun Young JANG, Young Jae LEE
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Publication number: 20230173055Abstract: The present invention relates to an influenza virus surface protein-derived recombinant hemagglutinin (HA) protein forming a trimer and use thereof, and more specifically to a recombinant vector for producing an influenza virus surface protein-derived HA protein forming a trimer, a transformant transformed by the recombinant vector, a method for producing an influenza virus surface protein-derived HA protein forming a trimer using the recombinant vector, an influenza virus surface protein-derived HA protein produced by the method, and the use thereof in preventing, ameliorating or treating influenza virus-infected disease.Type: ApplicationFiled: April 22, 2021Publication date: June 8, 2023Applicants: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION, BIOAPPLICATIONS INC, INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY, KONKUK UNIVERSITY INDUSTRIAL COOPERATION CORPInventors: In Hwan HWANG, Jun Ho LEE, Diao HAIPING, Shijian SONG, Woe Yeon KIM, Min Gab KIM, Gyeong Ryul RYU, Gyeong Im SHIN, Chang Seon SONG, Ji Ho LEE, Deok Hwan KIM
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Publication number: 20230113417Abstract: The present invention relates to a method for mass-producing a target protein in a plant and, more specifically, to a method for producing high levels of protein in plant leaf cells, in which an expression cassette construct for high expression of a target gene and an expression cassette construct for high expression of p38 as a gene silencing suppressor, are prepared, a binary vector for transient expression in plant cells, having the construct together, is then prepared, and the binary vector is then subjected to agrobacterium-mediated transformation by using a single agrobacterium culture.Type: ApplicationFiled: February 1, 2021Publication date: April 13, 2023Applicants: POSTECH ACADEMY-INDUSTRY FOUNDATION, BioApplications Inc.Inventors: In Hwan HWANG, Hyang Ju KANG, Jun Ho LEE, Shijian SONG, Selvan Thangarasu MUTHAMIL
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Patent number: 11484589Abstract: Provided is a swine fever antigen fused with a porcine Fc fragment, and more particularly, to a vaccine composition having an autoimmune-enhancing effect by binding the Fc fragment to a swine fever antigen, and a preparation method thereof.Type: GrantFiled: September 16, 2019Date of Patent: November 1, 2022Assignees: BIOAPPLICATIONS INC., REPUBLIC OF KOREA (ANIMAL AND PLANT QUARANTINE AGENCY)Inventors: Yongjik Lee, Dong-Jun An, Se Eun Choe, Jae-Young Song, In-Soo Cho
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Patent number: 11434496Abstract: Provided is a recombinant vector including a new BiP gene fragment, and when a target protein is prepared using the recombinant vector of the subject matter, use stability can be enhanced and the production amount of target protein can also be increased by minimizing a foreign peptide sequence remaining in the target protein.Type: GrantFiled: December 6, 2018Date of Patent: September 6, 2022Assignee: BIOAPPLICATIONS INC.Inventor: Yongjik Lee
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Publication number: 20220235366Abstract: Provided is a technique for highly expressing a target protein in a plant cell by using a glycosylation domain, a recombinant vector comprising a gene encoding a fusion protein of a glycosylation domain and a target protein, a recombinant cell, a transformed plant, and a method of producing a target protein using these.Type: ApplicationFiled: February 14, 2022Publication date: July 28, 2022Applicant: BIOAPPLICATIONS INC.Inventors: In Hwan HWANG, Hyang Ju KANG
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Patent number: 11279943Abstract: Provided is a technique for highly expressing a target protein in a plant cell by using a glycosylation domain, a recombinant vector comprising a gene encoding a fusion protein of a glycosylation domain and a target protein, a recombinant cell, a transformed plant, and a method of producing a target protein using these.Type: GrantFiled: January 17, 2018Date of Patent: March 22, 2022Assignee: BIOAPPLICATIONS INC.Inventors: In Hwan Hwang, Hyang Ju Kang
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Patent number: 10947278Abstract: Provided is a recombinant vector including a porcine Fc fragment. By fusing the porcine Fc fragment with various target proteins by using the recombinant vector of the present invention, not only target proteins may be expressed using various hosts including plants, but the productivity and stability of target proteins may also be increased.Type: GrantFiled: April 3, 2019Date of Patent: March 16, 2021Assignee: BIOAPPLICATIONS INC.Inventor: Yongjik Lee
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Patent number: 10857217Abstract: Provided is an antigen fused with a porcine Fc fragment, a vaccine composition having a self-adjuvanting effect by binding an Fc fragment to various antigens, and a method of producing the antigen.Type: GrantFiled: April 3, 2019Date of Patent: December 8, 2020Assignee: BIOAPPLICATIONS INC.Inventor: Yongjik Lee
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Publication number: 20200354737Abstract: Provided is a technique for highly expressing a target protein in a plant cell by using a glycosylation domain, a recombinant vector comprising a gene encoding a fusion protein of a glycosylation domain and a target protein, a recombinant cell, a transformed plant, and a method of producing a target protein using these.Type: ApplicationFiled: January 17, 2018Publication date: November 12, 2020Applicant: BIOAPPLICATIONS INC.Inventors: In Hwan HWANG, Hyang Ju KANG
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Publication number: 20200289641Abstract: Provided is a swine fever antigen fused with a porcine Fc fragment, and more particularly, to a vaccine composition having an autoimmune-enhancing effect by binding the Fc fragment to a swine fever antigen, and a preparation method thereof.Type: ApplicationFiled: September 16, 2019Publication date: September 17, 2020Applicants: BIOAPPLICATIONS INC., REPUBLIC OF KOREA (ANIMAL AND PLANT QUARANTINE AGENCY)Inventors: Yongjik LEE, Dong-Jun AN, Se Eun CHOE, Jae-Young SONG, In-Soo CHO
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Publication number: 20200263191Abstract: Provided is a recombinant vector including a new BiP gene fragment, and when a target protein is prepared using the recombinant vector of the subject matter, use stability can be enhanced and the production amount of target protein can also be increased by minimizing a foreign peptide sequence remaining in the target protein.Type: ApplicationFiled: December 6, 2018Publication date: August 20, 2020Applicant: BIOAPPLICATIONS INC.Inventor: Yongjik LEE
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Publication number: 20200087351Abstract: Provided is a recombinant vector including a porcine Fc fragment. By fusing the porcine Fc fragment with various target proteins by using the recombinant vector of the present invention, not only target proteins may be expressed using various hosts including plants, but the productivity and stability of target proteins may also be increased.Type: ApplicationFiled: April 3, 2019Publication date: March 19, 2020Applicant: BIOAPPLICATIONS INC.Inventor: Yongjik LEE
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Publication number: 20200085926Abstract: Provided is an antigen fused with a porcine Fc fragment, a vaccine composition having a self-adjuvanting effect by binding an Fc fragment to various antigens, and a method of producing the antigen.Type: ApplicationFiled: April 3, 2019Publication date: March 19, 2020Applicant: BIOAPPLICATIONS INC.Inventor: Yongjik LEE
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Publication number: 20180305710Abstract: A recombinant vector for transforming a plant, a plant transformed with the recombinant vector, a plant-made classical swine fever virus antigen pmE2 protein expressed in the plant and uses thereof is provided. By using a recombinant vector having a polynucleotide encoding a GP55 protein of CSFV according to the present invention; and a polynucleotide encoding a cellulose-binding domain protein; and a plant transformed with the recombinant vector, a plant-made classical swine fever virus antigen pmE2 protein may be produced with high efficiency, and has higher safety and stability than those achieved by other production methods. Also, since the plant-derived classical swine fever virus antigen protein pmE2 has a cellulose-binding domain (CBD) protein, it may be usefully used as an effective marker to determine a virus exposure pathway and an antibody producing pathway.Type: ApplicationFiled: May 12, 2016Publication date: October 25, 2018Applicants: BIOAPPLICATIONS INC., REPUBLIC OF KOREA (ANIMAL AND PLANT QUARANTINE AGENCY)Inventors: Dong Jun AN, Seong In LIM, Jae Young SONG, Hye Young JEOUNG, Eun Ju SOHN, In Hwan HWANG, Nam Jo PARK, Yong Jik LEE, Nam Hyung KIM, Sung Min GU
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Method for separating and purifying protein from plants using cellulose and cellulose binding domain
Patent number: 9512173Abstract: The present invention relates to a method of isolating a protein containing a cellulose binding domain from plants using various structures of cellulose and/or variants thereof. According to the method of isolating a protein, as a high affinity cellulose binding domain is used, a high purity recombinant protein is rapidly and effectively isolated in large quantities at low cost, and thus can be applied in various industrial fields.Type: GrantFiled: September 25, 2013Date of Patent: December 6, 2016Assignee: BIOAPPLICATIONS INC.Inventors: Inhwan Hwang, Soo Hong Park, Yong Jik Lee, Eun Ju Sohn, Kyung Min Min -
METHOD FOR SEPARATING AND PURIFYING PROTEIN FROM PLANTS USING CELLULOSE AND CELLULOSE BINDING DOMAIN
Publication number: 20150274772Abstract: The present invention relates to a method of isolating a protein containing a cellulose binding domain from plants using various structures of cellulose and/or variants thereof. According to the method of isolating a protein, as a high affinity cellulose binding domain is used, a high purity recombinant protein is rapidly and effectively isolated in large quantities at low cost, and thus can be applied in various industrial fields.Type: ApplicationFiled: September 25, 2013Publication date: October 1, 2015Applicant: BIOAPPLICATIONS INC.Inventors: Inhwan Hwang, Soo Hong Park, Yong Jik Lee, Eun Ju Sohn, Kyung Min Min