Patents Assigned to BIOASIS TECHNOLOGIES INC.
  • TREATMENT OF GAUCHER DISEASE
    Publication number: 20210113703
    Abstract: Disclosed are therapeutic payloads comprising p97 fragments coupled with active agents having blood-brain barrier (BBB) transport activity, including variants and combinations thereof, to facilitate delivery of therapeutic or diagnostic agents across the BBB. The therapeutic payloads can be effective in the treatment of Gaucher disease. Methods of treating Gaucher disease and pharmaceutical compositions are also disclosed.
    Type: Application
    Filed: May 18, 2019
    Publication date: April 22, 2021
    Applicant: Bioasis Technologies Inc.
    Inventors: Mei Mei Tian, Mark Day
  • P97-IDS fusion proteins
    Patent number: 10392605
    Abstract: Provided are fusion proteins between p97 (melanotransferrin) and iduronate-2-sulfatase (IDS), and related compositions and methods of use thereof, for instance, to facilitate delivery of IDS across the blood-brain barrier (BBB) and/or improve its tissue penetration in CNS and/or peripheral tissues, and thereby treat and/or diagnose Hunter Syndrome (Mucopolysaccharidosis type II; MPS II) and related lysosomal storage disorders, including those having a central nervous system (CNS) component.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: August 27, 2019
    Assignee: Bioasis Technologies Inc.
    Inventors: Timothy Z. Vitalis, Reinhard Gabathuler
  • Use of p97 As An Enzyme Delivery System For The Delivery of Therapeutic Lysosomal Enzymes
    Publication number: 20100303797
    Abstract: The present invention provides for compositions and methods for treating, ameliorating or preventing a lysosomal storage disease by administering to a patient suffering from a lysosomal storage disease a P97 conjugated with an enzyme which is capable of transportation into the lysosomes of cells on either sides of the blood brain barrier.
    Type: Application
    Filed: March 23, 2010
    Publication date: December 2, 2010
    Applicant: BIOASIS TECHNOLOGIES INC.
    Inventors: Christopher M. Starr, Todd Zankel