Abstract: Among other things, the present disclosure provides compositions and methods for an elastomeric cross-linked polyester material. Such an elastomeric cross-linked polyester material, in some embodiments, comprises a plurality of polymeric units of the general formula (-A-B-)p, wherein p is an integer greater than 1; and a plurality of urethane cross-links each of which covalently links two polymeric units to one another, which two linked polymeric unit each had at least one free hydroxyl or amino group prior to formation of the crosslink.
Type:
Grant
Filed:
January 11, 2022
Date of Patent:
May 30, 2023
Assignees:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC., BIOCANT-CENTER OF INNOVATION AND BIOTECHNOLOGY
Inventors:
Robert S. Langer, Jeffrey M. Karp, Maria Jose Maio Nunes-Pereira, Ben Ouyang, Lino da Silva Ferreira, Debanjan Sarkar
Abstract: Among other things, the present disclosure provides compositions and methods for an elastomeric cross-linked polyester material. Such an elastomeric cross-linked polyester material, in some embodiments, comprises a plurality of polymeric units of the general formula (-A-B-)p, wherein p is an integer greater than 1; and a plurality of urethane cross-links each of which covalently links two polymeric units to one another, which two linked polymeric unit each had at least one free hydroxyl or amino group prior to formation of the crosslink.
Type:
Grant
Filed:
February 25, 2021
Date of Patent:
February 22, 2022
Assignees:
Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., Biocant-Center of Innovation and Biotechnology
Inventors:
Robert S. Langer, Jeffrey M. Karp, Maria Jose Maio Nunes-Pereira, Ben Ouyang, Lino da Silva Ferreira, Debanjan Sarkar
Abstract: Among other things, the present disclosure provides compositions and methods for an elastomeric cross-linked polyester material. Such an elastomeric cross-linked polyester material, in some embodiments, comprises a plurality of polymeric units of the general formula (-A-B—)p, wherein p is an integer greater than 1; and a plurality of urethane cross-links each of which covalently links two polymeric units to one another, which two linked polymeric unit each had at least one free hydroxyl or amino group prior to formation of the crosslink.
Type:
Grant
Filed:
June 29, 2018
Date of Patent:
April 20, 2021
Assignees:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC., BIOCANT-CENTER OF INNOVATION AND BIOTECHNOLOGY
Inventors:
Robert S. Langer, Jeffrey M. Karp, Maria Jose Maio Nunes-Pereira, Ben Ouyang, Lino da Silva Ferreira, Debanjan Sarkar
Abstract: Among other things, the present disclosure provides compositions and methods for an elastomeric cross-linked polyester material. Such an elastomeric cross-linked polyester material, in some embodiments, comprises a plurality of polymeric units of the general formula (-A-B—)p, wherein p is an integer greater than 1; and a plurality of urethane cross-links each of which covalently links two polymeric units to one another, which two linked polymeric unit each had at least one free hydroxyl or amino group prior to formation of the crosslink.
Type:
Grant
Filed:
August 26, 2012
Date of Patent:
July 31, 2018
Assignees:
Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., Biocant-Center of Innovation and Biotechnology
Inventors:
Robert S. Langer, Jeffrey M. Karp, Maria Jose Maio Nunes-Pereira, Ben Ouyang, Lino Da Silva Ferreira, Debanjan Sarkar