Patents Assigned to Bio Capital Holdings, LLC
  • Publication number: 20230212588
    Abstract: Described herein are devices and methods for increasing the production of steviol glycosides, which have industrial and economic value. The steviol glycosides produced by the devices and methods disclosed herein do not require the ultra purification that is common in conventional or commercial methods and do not have a bitter aftertaste, making them better suited as flavor-enhancing additives to food, pharmaceutical, and nutritional supplement products.
    Type: Application
    Filed: June 9, 2022
    Publication date: July 6, 2023
    Applicant: Bio Capital Holdings, LLC
    Inventor: Raul CUERO RENGIFO
  • Patent number: 11639505
    Abstract: Described herein are UV-resistant or UV-protective biological devices and extracts produced therefrom. The biological devices include microbial cells transformed with a DNA construct containing genes for producing UV-resistant proteins such as, for example, hexokinase, heat shock proteins, alcohol dehydrogenase, transferrin, flavonol synthase, zinc oxidase, and iron oxidase. Methods for producing and using the devices are also described herein. Finally, compositions and methods for using the devices and extracts to reduce or prevent UV-induced damage or exposure to materials, items, plants, and human and animal subjects are described herein.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: May 2, 2023
    Assignee: Bio Capital Holdings, LLC
    Inventor: Raul Cuero Rengifo
  • Patent number: 11635439
    Abstract: Described herein are devices and methods for simultaneously expressing amyloid precursor protein and TonB protein. These devices and methods increase the production of these two proteins while also minimizing costs, making the proteins more widely accessible for medical research purposes, including the development of diagnostic tests for numerous diseases associated with elevated production of amyloid proteins. The amyloid precursor protein and TonB produced by the devices and methods described herein, as well as the devices themselves, can be used in experiments designed to model the interactions between metals and amyloids such as ?-amyloid that are characteristic of numerous diseases such as Alzheimer's. Finally, provided herein are diagnostic tests that can detect Alzheimer's disease in samples from patients; the tests are sensitive enough to identify diseases such as Alzheimer's even at pre-clinical stages, before the appearance of symptoms.
    Type: Grant
    Filed: June 17, 2020
    Date of Patent: April 25, 2023
    Assignee: Bio Capital Holdings, LLC
    Inventors: Raul Cuero Rengifo, Diana Vasquez Forero, Juliana Londoño Murillo
  • Patent number: 11603549
    Abstract: Described herein are devices and methods for using the same to produce carotenoids. The carotenoids produced by the devices and methods disclosed herein do not require the ultra purification that is common in conventional or commercial methods. The devices and methods disclosed herein also enhance one or more physical properties of plants treated with the devices described herein.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: March 14, 2023
    Assignee: Bio Capital Holdings, LLC
    Inventor: Raul Cuero Rengifo
  • Patent number: 11365417
    Abstract: Described herein are devices and methods for increasing the production of steviol glycosides, which have industrial and economic value. The steviol glycosides produced by the devices and methods disclosed herein do not require the ultra purification that is common in conventional or commercial methods and do not have a bitter aftertaste, making them better suited as flavor-enhancing additives to food, pharmaceutical, and nutritional supplement products.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: June 21, 2022
    Assignee: Bio Capital Holdings, LLC
    Inventor: Raul Cuero Rengifo
  • Publication number: 20210011029
    Abstract: Described herein are devices and methods for simultaneously expressing amyloid precursor protein and TonB protein. These devices and methods increase the production of these two proteins while also minimizing costs, making the proteins more widely accessible for medical research purposes, including the development of diagnostic tests for numerous diseases associated with elevated production of amyloid proteins. The amyloid precursor protein and TonB produced by the devices and methods described herein, as well as the devices themselves, can be used in experiments designed to model the interactions between metals and amyloids such as ?-amyloid that are characteristic of numerous diseases such as Alzheimer's. Finally, provided herein are diagnostic tests that can detect Alzheimer's disease in samples from patients; the tests are sensitive enough to identify diseases such as Alzheimer's even at pre-clinical stages, before the appearance of symptoms.
    Type: Application
    Filed: June 17, 2020
    Publication date: January 14, 2021
    Applicant: Bio Capital Holdings, LLC
    Inventors: Raul CUERO RENGIFO, Diana VASQUEZ FORERO, Juliana LONDOÑO MURILLO
  • Publication number: 20200270662
    Abstract: Described herein are biological devices and methods for using the same to produce a polyactive carbohydrate. The biological devices include microbial cells transformed with a DNA construct containing genes for producing a chitin synthase, a chitosanase, and a chitin deacetylase. In some instances, the biological devices also include a gene for lipase. Methods for using the polyactive carbohydrate are also provided herein, including, but not limited to, enhancing the physiological properties of plants; medical applications; applications in the construction, materials science, and home goods industries; personal care, grooming, cosmetics, and oral care compositions containing the polyactive carbohydrate; methods for water decontamination; and the production of polyurethanes.
    Type: Application
    Filed: September 12, 2018
    Publication date: August 27, 2020
    Applicant: Bio Capital Holdings, LLC
    Inventors: Raul CUERO RENGIFO, Juliana LONDONO MURILLO
  • Publication number: 20200270616
    Abstract: Described herein are devices and methods for increasing the production of steviol glycosides, which have industrial and economic value. The steviol glycosides produced by the devices and methods disclosed herein do not require the ultra purification that is common in conventional or commercial methods and do not have a bitter aftertaste, making them better suited as flavor-enhancing N additives to food, pharmaceutical, and nutritional supplement products.
    Type: Application
    Filed: September 10, 2018
    Publication date: August 27, 2020
    Applicant: Bio Capital Holdings, LLC
    Inventor: Raul CUERO RENGIFO
  • Publication number: 20200270667
    Abstract: Described herein are devices and methods for using the same to produce carotenoids. The carotenoids produced by the devices and methods disclosed herein do not require the ultra purification that is common in conventional or commercial methods. The devices and methods disclosed herein also enhance one or more physical properties of plants treated with the devices described herein.
    Type: Application
    Filed: September 10, 2018
    Publication date: August 27, 2020
    Applicant: Bio Capital Holdings, LLC
    Inventor: Raul CUERO RENGIFO
  • Publication number: 20200056188
    Abstract: Described herein are biological devices and methods for using the same to produce carbo sugars. The biological devices include microbial cells transformed with a DNA construct containing genes for producing a cellulose synthase and galactomannan galactosyltransferase. In some instances, the biological devices also include a gene for lipase. Methods for altering the viscosity of petroleum oil using the carbo sugars are also described herein. Finally, methods for degreasing or decontaminating water mixed with petroleum oil or other fatty substances or a surface coated with petroleum oil or other fatty substances using the carbo sugars are described herein.
    Type: Application
    Filed: October 30, 2017
    Publication date: February 20, 2020
    Applicant: Bio Capital Holdings, LLC
    Inventors: Raul CUERO RENGIFO, Juliana LONDONO MURILLO, Mariana SANCHEZ LONDONO, Daniel AGUDELO VALENCIA, Juan Miguel SANCHEZ BUSTAMANTE, Mario Antonio FRANCO JIMENEZ, Lina Clemencia SANCHEZ BUSTAMANTE
  • Publication number: 20190338326
    Abstract: Described herein are biological devices and methods for using the same to produce carbo sugars. The biological devices include microbial cells transformed with a DNA construct containing genes for producing a cellulose synthase and galactomannan galactosyltransferase. In some instances, the biological devices also include a gene for lipase. Methods for altering the viscosity of petroleum oil using the carbo sugars are also described herein. Finally, methods for degreasing or decontaminating water mixed with petroleum oil or other fatty substances or a surface coated with petroleum oil or other fatty substances using the carbo sugars are described herein.
    Type: Application
    Filed: April 30, 2019
    Publication date: November 7, 2019
    Applicant: Bio Capital Holdings, LLC
    Inventors: Raul CUERO RENGIFO, Juliana LONDOÑO MURILLO, Mariana SANCHEZ LONDOÑO, Daniel AGUDELO VALENCIA, Juan SANCHEZ BUSTAMANTE, Mario Antonio FRANCO JIMENEZ, Lina Clemencia SANCHEZ BUSTAMANTE