Patents Assigned to BioChem Pharma Inc.
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Publication number: 20030004175Abstract: (−)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one, its pharmaceutically acceptable derivatives, pharmaceutical formulation thereof, methods for its preparation and its uses as an antiviral agent are describedType: ApplicationFiled: January 30, 2001Publication date: January 2, 2003Applicant: BioChem Pharma Inc.Inventors: Jonathan Allan Coates, Ian Martin Mutton, Charles Richard Penn, Christopher Williamson, Richard Storer
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Publication number: 20020137947Abstract: A novel compound which inhibits certain integrins, particularly &agr;v integrins. Additionally, the novel compound may be used in a method of treating tumors or cancer which comprises administering a pharmaceutically effective amount of the compound to a patient. Additionally, the novel compound may be used in a method of inhibiting angiogensis. Finally, a method of producing the novel compound is disclosed.Type: ApplicationFiled: January 16, 2002Publication date: September 26, 2002Applicant: BioChem Pharma Inc.Inventors: Denis Labrecque, Serge Lamothe, Marc Courchesne, Laval Chan, Giorgio Attardo, Karen Meerovitch
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Patent number: 6444656Abstract: The present invention relates to a novel nucleotide analogue having the general formula (I) and pharmaceutically acceptable salts, esters, or salt of such esters: wherein n, X, Q U R1′, R1, Z and R2 are defined here within. The compounds object of the present invention may be a single enantiomers or as mixtures of said enantiomers, the compounds may have a &agr;D, &agr;-L, &bgr;-D, &bgr;-L, R or S configuration at each chiral center or mixtures thereof. This invention also relates to pharmaceutical compositions containing them, alone or in combination with other therapeutic agents, and their use as antiviral agents, particularly against HIV and/or HBV infections in mammals.Type: GrantFiled: March 24, 2000Date of Patent: September 3, 2002Assignee: BioChem Pharma, Inc.Inventors: Nghe Nguyen-Ba, Rabindra Rej
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Publication number: 20020107225Abstract: The present invention provides a novel method for treating leukemia and more particularly acute myelogenous leukemia (AML) in a host comprising administering to the host a therapeutically effective amount of a compound having the formula I: 1Type: ApplicationFiled: January 16, 2002Publication date: August 8, 2002Applicant: BioChem Pharma Inc.Inventors: Henriette Gourdeau, Francis J. Giles
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Publication number: 20020099072Abstract: The present invention is concerned with novel [1,8] naphthyridine derivatives useful for the inhibition of the hepatitis virus, more specifically the hepatitis C virus.Type: ApplicationFiled: December 27, 2001Publication date: July 25, 2002Applicant: BioChem Pharma Inc.Inventors: Benoit Bachand, Nghe Nguyen-Ba, Arshad Siddiqui, Sophie Levesque
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Publication number: 20020058670Abstract: The present invention relates to methods and compositions for preparing biologically important nucleoside analogues containing 1,3-dioxolane sugar rings. In particular, this invention relates to the stereoselective synthesis of the beta (cis) isomer by glycosylating the base with an intermediate of formula (II) below a temperature of about −10° C.Type: ApplicationFiled: November 16, 2001Publication date: May 16, 2002Applicant: BIOCHEM PHARMA INC.Inventors: Tarek Mansour, Alex Cimpoia, Krzysztof Bednarski
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Patent number: 6369066Abstract: This invention relates to single enantiomers of novel cis-substituted 1,3-oxathiolanes, of the formula (I): wherein; R1 is hydrogen, and R2 is cytosine or 5-fluorocytosine; and pharmaceutically acceptable salts and esters thereof. This invention also relates to pharmaceutical compositions containing them and to the use of these compounds as antiviral agents, particularly in combination therapy.Type: GrantFiled: November 28, 2000Date of Patent: April 9, 2002Assignee: BioChem Pharma, Inc.Inventors: Tarek S. Mansour, Haolun Jin
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Patent number: 6358963Abstract: The current invention is down to (+) an (−) enantiomers, as well as racemic mixtures of nucleoside analogs, wherein the carbohydrate portion of the analog is a dioxolane moiety and the nucleobase moiety is N6-carbocyclic-alkylamino-substituted-2-amino-purine moiety attached via its N9 position to the dioxolane moiety. The compounds are useful for treating viral infections such as HBV and HIV infections, alone or in combination with other therapeutic agents.Type: GrantFiled: December 22, 1999Date of Patent: March 19, 2002Assignee: BioChem Pharma Inc.Inventor: Nghe Nguyen-Ba
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Patent number: 6350753Abstract: Nucleoside analogues containing a 1,3-dioxolane structure are suitable antiviral agents, particulary for the treatment of the HIV infections in mammals, especially humans. Examples of the nucleoside analogues include: cis-2-acetoxymethyl-4-(thymin-1′-yl)-1,3,-dioxolane, cis-2-hydroxymethyl-4-(thymin-1′-yl)-1,3-dioxolane, cis-2-benzoyloxymethyl-4-(cytosin-1′-yl)-1,3-dioxolane, and cis-2-hydroxymethyl-4-(cytosin-1′-yl)-1,3-dioxolane. These compounds can be in the form of their racemates or their separate enantiomers.Type: GrantFiled: September 30, 1998Date of Patent: February 26, 2002Assignee: Biochem Pharma Inc.Inventors: Bernard Belleau, Dilip M. Dixit, Paul Nguyen-Ba
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Publication number: 20010049372Abstract: In accordance with the present invention there is provided a nucleoside analogue of formula (I) or (Ia) which is useful as an antiviral agent.Type: ApplicationFiled: June 29, 2001Publication date: December 6, 2001Applicant: BioChem Pharma Inc.Inventor: Nghe Nguyen-Ba
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Publication number: 20010041797Abstract: Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: 1Type: ApplicationFiled: January 16, 2001Publication date: November 15, 2001Applicant: BioChem Pharma Inc.Inventors: Bernard Belleau, Tarek Mansour, Allan Tse, Colleen A. Evans, Haolun Jin, Boulos Zacharie, Nghe Nguyen-Ba
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Publication number: 20010031765Abstract: The present invention relates to heterocyclic Compounds having antiviral activity.Type: ApplicationFiled: February 5, 2001Publication date: October 18, 2001Applicant: BioChem Pharma Inc.Inventors: Jean Bedard, Robert Rando, Jean-Francois Lavallee, Guy Falardeau
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Patent number: 6287574Abstract: A highly conserved, immunologically accessible antigen at the surface of Neisseria meningitidis organisms. Immunotherapeutic, prophylactic and diagnostic compositions and methods useful in the treatment, prevention an diagnosis of Neisseria meningitidis diseases. A proteinase K resistant Neisseria meningitidis surface protein having an apparent molecular weight of 22 kDa, the corresponding nucleotide and derived amino acid sequences (SEQ ID NO: 1, NO:3, NO:5 and NO:7: SEQ ID NO: 2, NO:4, NO:6, and NO:8), recombinant DNA methods for the production of the Neisseria meningitidis 22 kDA surface protein, and antibodies that bind to the Neisseria meningitidis 22 kDA surface protein.Type: GrantFiled: November 13, 1997Date of Patent: September 11, 2001Assignee: BioChem Pharma Inc.Inventors: Bernard R. Brodeur, Denis Martin, Josee Hamel, Clement Rioux
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Patent number: 6274620Abstract: The present invention comprises compounds that are effective inhibitors of integrins, particularly &agr;v&bgr;3 and &agr;v&bgr;5 integrins. Particularly, the compounds are of formula I and pharmaceutically acceptable salts thereof wherein X,Y1 W, R1 to R5, A and B are defined according to the disclosure herein.Type: GrantFiled: June 7, 2000Date of Patent: August 14, 2001Assignee: BioChem Pharma Inc.Inventors: Denis Labrecque, Giorgio Attardo, Monica Bubenik, Laval Chan, Sylvie Charron, Réal Denis, Guy Falardeau, Serge Lamothe, Patrice Préville, Boulos Zacharie
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Patent number: 6255318Abstract: The present invention relates to heterocyclic Compounds having antiviral activity. In particular, Compounds of formula (I): wherein B, W, X, Y, Q, R1, R2, R3, R4 and n are as defined herein, are useful in the therapy and prophylaxis of viral infection in mammals.Type: GrantFiled: December 11, 1998Date of Patent: July 3, 2001Assignee: Biochem Pharma Inc.Inventors: Jean Bédard, Robert Rando, Jean-Francois Lavallée, Guy Falardeau
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Patent number: 6228860Abstract: This invention relates to single enantiomers of novel cis-substituted 1,3-oxathiolanes, of the formula (I): wherein; R1 is hydrogen, and R2 is cytosine or 5-fluorocytosine, and pharmaceutically acceptable salts and esters thereof. This invention also relates to pharmaceutical compositions containing them and to the use of these compounds as antiviral agents, particularly in combination therapy.Type: GrantFiled: November 26, 1996Date of Patent: May 8, 2001Assignee: Biochem Pharma Inc.Inventors: Tarek S. Mansour, Haolun Jin
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Patent number: 6194576Abstract: Nucleotide analogues having the general formula (I) and pharmaceutically acceptable derivatives: wherein n is 0 or an integer; X is O or S, CH2, CH-halogen, CH—N3, or C═CH2; Q and U are independently selected from: O, S, and CH(Ra) wherein Ra is hydrogen, OH, halogen, N3 ,NH2, SH, carboxyl, C1-6 alkyl or Ra is CH2(Rb) wherein Rb is hydrogen, OH, SH, NH2, C1-6 alkyl or carboxyl; or both Q and U are CH when Q and U are linked by a double bond; Z is selected from: O, a C1-6 alkoxy, a C1-6 thioalkyl, a C1-6 aminoalkyl, (CH2)m wherein m is 0 or an integer, and N(Rc)2 wherein both Rc are independently hydrogen or a C1-6 alkyl; and R2 is a purine or pyrimidine base or an analogue or derivative thereof. Members of this series of analogues possess anti-viral activity.Type: GrantFiled: October 4, 1999Date of Patent: February 27, 2001Assignee: BioChem Pharma, Inc.Inventors: Nghe Nguyen-Ba, Miguel Quimpere, Laval Chan Chun Kong, William L. Brown, Gervais Dionne
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Patent number: 6180639Abstract: (−)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one, its pharmaceutically acceptable derivatives, pharmaceutical formulation thereof, methods for its preparation and its uses as an antiviral agent are described.Type: GrantFiled: February 20, 1992Date of Patent: January 30, 2001Assignee: BioChem Pharma Inc.Inventors: Jonathan Allan Coates, Ian Martin Mutton, Charles Richard Penn, Christopher Williamson, Richard Storer
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Patent number: 6175008Abstract: Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: wherein R2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S═O or SO2. The invention also relates to intermediates of use in the preparation of these compounds.Type: GrantFiled: June 6, 1995Date of Patent: January 16, 2001Assignee: BioChem Pharma Inc.Inventors: Bernard Belleau, Tarek Mansour, Allan Tse, Colleen A. Evans, Haolun Jin, Boulos Zacharie, Nghe Nguyen-Ba
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Patent number: 6156737Abstract: The present invention is directed to a method of treating hepatitis B viral infections in mammals comprising the administration of .beta.-L-5-fluoro-2',3'-dideoxycytidine and pharmaceutically acceptable derivatives thereof.Type: GrantFiled: April 12, 1995Date of Patent: December 5, 2000Assignee: BioChem Pharma Inc.Inventors: Tarek Mansour, Allan H.L. Tse