Patents Assigned to BioChemics, Inc.
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Patent number: 10751309Abstract: A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal. for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient.Type: GrantFiled: January 15, 2016Date of Patent: August 25, 2020Assignee: BioChemics, Inc.Inventors: Stephen G. Carter, Zhen Zhu, Kanu Patel, John J. Masiz
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Patent number: 10624867Abstract: The invention provides a topical formulation for treating pain comprising a nonsteroidal anti-inflammatory agent or a Cox-2 inhibitor and a gabapentin family member.Type: GrantFiled: May 9, 2018Date of Patent: April 21, 2020Assignee: Biochemics, Inc.Inventors: Gyula Varadi, Zhen Zhu, John J. Masiz, Stephen G. Carter
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Patent number: 10537536Abstract: A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal. for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient.Type: GrantFiled: December 28, 2015Date of Patent: January 21, 2020Assignee: BioChemics, Inc.Inventors: Stephen G. Carter, Zhen Zhu, Kanu Patel, John J. Masiz
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Patent number: 10322077Abstract: Methods and formulations for removing a tattoo by using a cell disrupter in combination with a vasodilator, and optionally one or more of an osmotic modifying agent, a chelation agent, and an occlusive modifying agent. Embodiments optionally further include using one or more of an antibiotic, anesthetic, penetration enhancer, excipient, carrier and vehicle.Type: GrantFiled: January 28, 2016Date of Patent: June 18, 2019Assignee: BioChemics, Inc.Inventors: Stephen G. Carter, Zhen Zhu, Kanu Patel, Diane L. Kozwich, Laura Stephens, John J. Masiz, David H. Donabedian
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Patent number: 9566256Abstract: A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal. for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient.Type: GrantFiled: September 22, 2009Date of Patent: February 14, 2017Assignee: Biochemics, Inc.Inventors: Stephen G. Carter, Zhen Zhu, Kanu Patel, John J. Masiz
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Patent number: 9561174Abstract: Set forth herein is a preparation of ibuprofen (2-(4-isobutylphenyl) propionic acid) in the free acid form that is suitable for topical administration. The topical ibuprofen formulation is prepared by dissolving the free acid form of ibuprofen, or preparing a homogeneous suspension of the free acid form of ibuprofen, in the presence of a pharmaceutically acceptable solvent so as to produce a topical drug formulation compatible with the penetration of 2-(4-isobutylphenyl) propionic acid through the skin tissue. Topical formulations of ibuprofen can be based on a pharmaceutically acceptable solvent such as, e.g., a pyrrolidone solvent or dimethylacetamide.Type: GrantFiled: September 5, 2012Date of Patent: February 7, 2017Assignee: BioChemics, Inc.Inventors: Stephen G. Carter, Zhen Zhu, Kanu Patel, Diane Kozwich
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Patent number: 9278233Abstract: Methods and formulations for removing a tattoo by using a cell disrupter in combination with a vasodilator, and optionally one or more of an osmotic modifying agent, a chelation agent, and an occlusive modifying agent. Embodiments optionally further include using one or more of an antibiotic, anesthetic, penetration enhancer, excipient, carrier and vehicle.Type: GrantFiled: December 4, 2009Date of Patent: March 8, 2016Assignee: BioChemics, Inc.Inventors: Stephen G. Carter, Zhen Zhu, Kanu Patel, Diane L. Kozwich, Laura Stephens, John J. Masiz, David H. Donabedian
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Patent number: 8802085Abstract: A method for treating a patient suffering from a wound, ulcer, or inflammation includes providing a topical formulation comprising a carrier and a combination of active ingredients that includes at least one retinoid and at least one blood vessel dilator, and applying the topical formulation to the skin of the patient to cause healing, accelerated healing or prevention of the wound, ulcer or inflammation. Additional active ingredients may include a promoter of mitochondrial function or an antioxidant.Type: GrantFiled: December 4, 2012Date of Patent: August 12, 2014Assignee: BioChemics, Inc.Inventors: Stephen G. Carter, Zhen Zhu, Kanu Patel, Diane L. Kozwich
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Publication number: 20130245538Abstract: In a method for treating an affected skin region of a patient having a skin disorder, a vasodilation composition is applied to an affected skin region of a patient, the affected skin region exhibiting a skin disorder characterized by at least one abnormal blood vessel, and the affected skin region is then treated so as to non-invasively disrupt tissue architecture, e.g., by inducing ischemia, of the at least one abnormal blood vessel. A vasoconstriction composition can then be applied to the skin region to cause vasoconstriction of the at least one blood vessel in order to promote healing.Type: ApplicationFiled: January 3, 2013Publication date: September 19, 2013Applicant: BIOCHEMICS, INC.Inventors: Stephen G. Carter, John J. Masiz, Laura Stephens, Zhen Zhu, Kanu Patel, David H. Donabedian
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Patent number: 8367122Abstract: In a method for treating an affected skin region of a patient having a skin disorder, a vasodilation composition is applied to an affected skin region of a patient, the affected skin region exhibiting a skin disorder characterized by at least one abnormal blood vessel, and the affected skin region is then treated so as to non-invasively disrupt tissue architecture, e.g., by inducing ischemia, of the at least one abnormal blood vessel. A vasoconstriction composition can then be applied to the skin region to cause vasoconstriction of the at least one blood vessel in order to promote healing.Type: GrantFiled: June 11, 2009Date of Patent: February 5, 2013Assignee: BioChemics, Inc.Inventors: Laura Stephens, John J. Masiz, Stephen G. Carter, Zhen Zhu, Kanu Patel
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Patent number: 8354116Abstract: The synthesis and use of bifunctional molecules to improve the topical and transdermal delivery efficiency of various types of therapeutic agents or agents designed to promote the transdermal delivery of those therapeutic agents either into the skin tissue or into the systemic circulation. Three major classes of molecules are covalently joined as bifunctional substances; chemical vasodilators, passive dermal penetration enhancers and therapeutic or diagnostic drugs. Chemical vasodilators may be delivered into the skin to increasing the blood flow in a tissue that has compromised circulation or they may be used as part of a delivery vehicle to promote the delivery of the drug. Passive dermal penetration enhancers are those chemicals that promote the passive penetration of drugs and other chemicals through the stratum corneum and epidermis of the skin tissue. Drugs and diagnostic agents are the third group of chemicals that are candidates for the linkage of molecules.Type: GrantFiled: June 18, 2007Date of Patent: January 15, 2013Assignee: BioChemics, Inc.Inventors: Stephen G. Carter, Kanu Patel, Zhen Zhu, Lixin Qiao
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Patent number: 8343486Abstract: A method for treating a patient suffering from a wound, ulcer, or inflammation includes providing a topical formulation comprising a carrier and a combination of active ingredients that includes at least one retinoid and at least one blood vessel dilator, and applying the topical formulation to the skin of the patient to cause healing, accelerated healing or prevention of the wound, ulcer or inflammation. Additional active ingredients may include a promoter of mitochondrial function or an antioxidant.Type: GrantFiled: January 22, 2009Date of Patent: January 1, 2013Assignee: BioChemics, Inc.Inventors: Stephen G. Carter, Zhen Zhu, Kanu Patel, Diane L. Kozwich
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Publication number: 20120329875Abstract: Set forth herein is a preparation of ibuprofen (2-(4-isobutylphenyl) propionic acid) in the free acid form that is suitable for topical administration. The topical ibuprofen formulation is prepared by dissolving the free acid form of ibuprofen, or preparing a homogeneous suspension of the free acid form of ibuprofen, in the presence of a pharmaceutically acceptable solvent so as to produce a topical drug formulation compatible with the penetration of 2-(4-isobutylphenyl) propionic acid through the skin tissue. Topical formulations of ibuprofen can be based on a pharmaceutically acceptable solvent such as, e.g., a pyrrolidone solvent or dimethylacetamide.Type: ApplicationFiled: September 5, 2012Publication date: December 27, 2012Applicant: BioChemics, Inc.Inventors: Stephen G. Carter, Zhen Zhu, Kanu Patel, Diane L. Kozwich
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Publication number: 20100145256Abstract: Methods and formulations for removing a tattoo by using a cell disrupter in combination with a vasodilator, and optionally one or more of an osmotic modifying agent, a chelation agent, and an occlusive modifying agent. Embodiments optionally further include using one or more of an antibiotic, anesthetic, penetration enhancer, excipient, carrier and vehicle.Type: ApplicationFiled: December 4, 2009Publication date: June 10, 2010Applicant: BioChemics, Inc.Inventors: Stephen G. Carter, Zhen Zhu, Kanu Patel, Diane L. Kozwich, Laura Stephens, John J. Masiz, David H. Donabedian
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Publication number: 20100137443Abstract: Set forth herein is a preparation of ibuprofen (2-(4-isobutylphenyl)propionic acid) in the free acid form that is suitable for topical administration. The topical ibuprofen formulation is prepared by dissolving the free acid form of ibuprofen, or preparing a homogeneous suspension of the free acid form of ibuprofen, in the presence of a pharmaceutically acceptable solvent so as to produce a topical drug formulation compatible with the penetration of 2-(4-isobutylphenyl) propionic acid through the skin tissue. Topical formulations of ibuprofen can be based on a pharmaceutically acceptable solvent such as, e.g., a pyrrolidone solvent or dimethylacetamide.Type: ApplicationFiled: September 10, 2009Publication date: June 3, 2010Applicant: BIOCHEMICS, INC.Inventors: Stephen G. Carter, Zhen Zhu, Kanu Patel, Diane L. Kozwich
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Publication number: 20100076035Abstract: A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal. for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient.Type: ApplicationFiled: September 22, 2009Publication date: March 25, 2010Applicant: BIOCHEMICS, INC.Inventors: Stephen G. Carter, Zhen Zhu, Kanu Patel, John J. Masiz
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Publication number: 20100003353Abstract: In a method for treating an affected skin region of a patient having a skin disorder, a vasodilation composition is applied to an affected skin region of a patient, the affected skin region exhibiting a skin disorder characterized by at least one abnormal blood vessel, and the affected skin region is then treated so as to non-invasively disrupt tissue architecture, e.g., by inducing ischemia, of the at least one abnormal blood vessel. A vasoconstriction composition can then be applied to the skin region to cause vasoconstriction of the at least one blood vessel in order to promote healing.Type: ApplicationFiled: June 11, 2009Publication date: January 7, 2010Applicant: BIOCHEMICS, INC.Inventors: Laura Stephens, John J. Masiz, Stephen G. Carter, Zhen Zhu, Kanu Patel
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Publication number: 20090214504Abstract: A method for treating a patient suffering from a wound, ulcer, or inflammation includes providing a topical formulation comprising a carrier and a combination of active ingredients that includes at least one retinoid and at least one blood vessel dilator, and applying the topical formulation to the skin of the patient to cause healing, accelerated healing or prevention of the wound, ulcer or inflammation. Additional active ingredients may include a promoter of mitochondrial function or an antioxidant.Type: ApplicationFiled: January 22, 2009Publication date: August 27, 2009Applicant: BIOCHEMICS, INC.Inventors: Stephen G. Carter, Zhen Zhu, Kanu Patel, Diane L. Kozwich
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Patent number: 6635274Abstract: An efficient transdermal delivery system for delivering an active ingredient to the blood supply of a living body, comprising a vasodilator, an active ingredient, and a permeation enhancer for the active ingredient. The components of this mixture are combined in a manner that dissolves them into solution, eliminating the need for a polymeric binding agent and thus diminishing the total molecular weight of the mixture and increasing the penetration and delivery efficiency of the active drug molecules.Type: GrantFiled: October 27, 2000Date of Patent: October 21, 2003Assignee: BioChemics, Inc.Inventors: John J. Masiz, Stephen G. Carter