Abstract: A pharmaceutical composition for promoting osteoblastogenesis, in particular a yeast cell derived product for use for promoting osteoblastogenesis in an individual. The yeast cell-derived product may be derived from yeast cells of the genus Saccharomyces and from yeast cells of the species Saccharomyces boulardii.
Type:
Application
Filed:
September 2, 2021
Publication date:
September 7, 2023
Applicant:
BIOCODEX
Inventors:
Marie-Emmanuelle LE GUERN, Marc VERLEYE
Abstract: The present invention relates to a pharmaceutical oral formulation for use in the administration of at least two bacteria derived from fecal microbiota to mammals for the treatment and/or prevention of dysbiosis and associated pathologies. The pharmaceutical oral formulation is encapsulated mixture of at least two bacteria derived from fecal microbiota wherein the capsules are coated in a pH responsive polymer composition comprising: a. 50-70% poly(methyl acrylate-co-methyl methacrylate-co-methacrylic acid) 7:3:1 by weight of dry polymer, b. 10-30% poly(methacrylic acid-co-ethyl acrylate) 1:1 by weight of dry polymer, c. at least one fatty acid mono-, di- or tri-glyceride ester, or mixtures thereof, d. at least one plasticizer, e. at least one non-ionic emulsifier. The pharmaceutical oral formulation is especially designed to be delivered principally in the ileum and colon and to maintain the sample bacterial viability and diversity.
Abstract: The present invention relates to a compound of the following formula (I): or a pharmaceutically acceptable salt thereof, for use in the prevention or treatment of obsessions and/or compulsions in an individual.
Type:
Grant
Filed:
November 20, 2014
Date of Patent:
June 30, 2020
Assignee:
BIOCODEX
Inventors:
Marc Verleye, Marie-Emmanuelle Le Guern
Abstract: The present invention relates to a compound of the following formula (I): or a pharmaceutically acceptable salt thereof, for use in the prevention or treatment of autism spectrum disorders (ASD).
Type:
Grant
Filed:
July 23, 2018
Date of Patent:
June 9, 2020
Assignee:
BIOCODEX
Inventors:
Bernard Hublot, Rene Levy, Marie-Emmanuelle Le Guern
Abstract: The present invention relates to a dietary supplement or pharmaceutical composition, comprising lyophylized Saccharomyces boulardii as an active ingredient and as sole probiotic, optionally in association with a pharmaceutically acceptable vehicle, wherein the composition is in a closed vial a having a first airtight compartment comprising lyophilized S. boulardii powder, and a second compartment comprising a solution, wherein the first and second compartment can be brought in airtight communication with one another to yield a suspension of S. boulardii to be administered to an individual upon opening of the vial.
Type:
Grant
Filed:
June 11, 2015
Date of Patent:
January 7, 2020
Assignee:
BIOCODEX
Inventors:
Jean-Marie Lefevre, Gilles Renaud, Marie-Emmanuelle Le Guern
Abstract: The present invention relates to a compound of the following formula (I): or a pharmaceutically acceptable salt thereof, to be used in the prevention or treatment of light-induced damage and/or a degeneration of the retina in a patient.
Type:
Grant
Filed:
January 28, 2015
Date of Patent:
January 23, 2018
Assignee:
BIOCODEX
Inventors:
Marc Verleye, Philippe Girard, Marie-Emmanuelle Le Guern
Abstract: The present invention relates to a compound of the following formula (I): or a pharmaceutically acceptable salt thereof, for use in the prevention or treatment of peripheral neuropathies.
Type:
Grant
Filed:
March 18, 2010
Date of Patent:
January 6, 2015
Assignee:
Biocodex
Inventors:
Marie-Emmanuelle Le Guern, Marc Verleye, Jean-Marie Gillardin, Bernard Hublot
Abstract: The present invention relates to certain purines, which act as topoisomerase II catalytic inhibitors. These compounds are useful in combination with topoisomerase II poisons, such as anthracyclines and epipodophyllotoxins, in the treatment of proliferative conditions (e.g., cancer). These compounds are useful in the treatment of tissue damage associated with extravasation of a topoisomerase II poison, such as an anthracycline or an epipodophyllotoxin.
Abstract: The present invention relates to a pharmaceutical composition comprising as active substances: at least one compound of the following general formula (I): and at least one inhibitor of type 2 cyclooxygenase (COX-2), notably for use in the prevention or treatment of pain.
Type:
Grant
Filed:
December 3, 2010
Date of Patent:
December 3, 2013
Assignee:
Biocodex
Inventors:
Philippe Girard, Marie-Emmanuelle Le Guern, Jean-Marie Gillardin, Bernard Hublot
Abstract: The present invention relates to a pharmaceutical composition comprising as active substances: at least one compound of the following general formula (I): and at least one compound of the following general formula (V): especially for its use in the prevention or treatment of pain.
Type:
Grant
Filed:
October 28, 2009
Date of Patent:
November 5, 2013
Assignee:
Biocodex
Inventors:
Philippe Girard, Marie-Emmanuelle Le Guern, Laurence Berthon-Cedille, Jean-Marie Gillardin, Bernard Hublot
Abstract: The present invention relates to the use of at least one compound of formula (I) below: or at least one of the pharmaceutically acceptable salts thereof, for the preparation of a medicament intended for the prevention or for the treatment of cerebral edemas.
Type:
Grant
Filed:
June 5, 2006
Date of Patent:
April 16, 2013
Assignee:
Biocodex
Inventors:
Marie-Emmanuelle Le Guern, Philippe Girard, Jean-Marie Gillardin, Laurence Berthon-Cedille, Bernard Hublot
Abstract: This invention relates to the use of at least one compound of the following formula (I): or its pharmaceutically acceptable salts, for the preparation of a medicinal compound having neuroprotective activity intended to prevent or treat neurone deteriorations.
Type:
Grant
Filed:
July 18, 2006
Date of Patent:
December 25, 2012
Assignee:
Biocodex
Inventors:
Marc Verleye, Marie-Emmanuelle Le Guern, Philippe Girard, Jean-Marie Gillardin, Laurence Berthon-Cedille, Bernard Hublot
Abstract: The invention relates to a method of preparation of fluoroquinolones of formula (I) from compounds of formula (II): in which R1, R2, R3, R4, R5, R6, R7, and X are as defined in Claim 1.
Type:
Grant
Filed:
May 22, 2008
Date of Patent:
January 10, 2012
Assignee:
Biocodex
Inventors:
Laurence Berthon-Cedille, Marie-Emmanuelle Leguern, Gilles Renaud, Francis Tombret
Abstract: The invention relates to the use of L-citrulline (I) or of one of its pharmaceutically acceptable salts in the preparation of a drug for the treatment of states or undernutrition as linked to a lowering of protein synthesis within the framework of pathologies which do not result from an intestinal insufficiency.
Abstract: The present invention relates to a method of treating or preventing weight loss of patients with inflammatory bowel diseases comprising administering to said patients an effective amount of Saccharomyces boulardii.
Type:
Grant
Filed:
December 23, 2004
Date of Patent:
September 21, 2010
Assignee:
Biocodex
Inventors:
Bernard Hublot, Herve Groux, Rene Levy, Marie-Emmanuelle Le Guern, Paul Bernasconi
Abstract: The present invention relates to the use of at least one compound of formula (I) below: or of its pharmaceutically acceptable salts, in the preparation of a medicament for the prevention or treatment of cerebral oedemas.
Type:
Grant
Filed:
July 18, 2006
Date of Patent:
August 4, 2009
Assignee:
Biocodex
Inventors:
Marie-Emmanuelle Le Guern, Philippe Girard, Jean-Marie Gillardin, Laurence Berthon-Cedille, Bernard Hublot
Abstract: The present invention relates to the use of L-citrulline (I) for the preparation of a medicament intended for the treatment of pathologies linked to an intestinal insufficiency.
Type:
Application
Filed:
June 30, 2006
Publication date:
November 2, 2006
Applicants:
BIOCODEX, UNIVERSITE RENE DESCARTES PARIS 5
Inventors:
Sylwia Osowska-Vincent, Christophe Moinard, Luc Cynober, Marie-Emmanuelle Le Guern, Bernard Hublot, Paul Bernasconi
Abstract: Process for reducing the extent of Cryptosporidium diarrhoeas, which comprises administering to a patient in need thereof a therapeutically effective amount of yeasts of the Saccharomyces boulardii species. The yeasts are freeze-dried living yeasts. The yeasts are provided in the form of unit doses containing 0.050 to 3.0 g of yeasts.