Patents Assigned to Biocompatibles, UK
-
Publication number: 20230355833Abstract: The present disclosure relates to radiopaque PVA polymers where the PVA has a first pendant group and a second pendant group, wherein the first pendant group comprises a first phenyl group bearing 1 to 5 iodine atoms, and the second pendant group comprises either (a) a second phenyl group bearing 1 to 3 substituents selected from the group W and optionally 1 to 4 iodine substituents, the group(s) W and the optional iodines being the sole substituents of the second phenyl group. Each W is selected from —OH, —COOH, —SO3H, —OPO3H2, —O—(C1-4alkyl), —O—(C1-4alkyl)OH, —O—(C1-4alkyl)R2, —O—(C2H5O)qR1 —(C?O)—O— C1-4alkyl and —O—(C?O)C1-4alkyl; wherein R1 is H or C1-4 alkyl; R2 is —COOH, —SO3H, or —OPO3H2; q is an integer from 1 to 4; wherein the group W may be in the form of a pharmaceutically acceptable salt; or (b) a pyridyl group; which is optionally in the form of a pyridinium ion.Type: ApplicationFiled: July 18, 2023Publication date: November 9, 2023Applicant: BIOCOMPATIBLES UK LIMITEDInventors: Koorosh Ashrafi, Hugh Britton, Francesco Cuda, Andrew Lennard Lewis, Cristian Parisi, Yiqing Tang, Sean Leo Willis
-
Patent number: 11786285Abstract: A cryoablation tool has a primary fluid circuit for cryogenically cooling or heating tissue surrounding the distal portion of the cryoablation tool. The primary fluid circuit has a primary-primary heat exchanger facilitating recuperative heat exchange between a high pressure stream of a primary fluid and a low pressure stream of the primary fluid. The cryoablation tool has a secondary fluid circuit having a secondary-secondary heat exchanger for permitting recuperative heat exchange between a high pressure stream of a secondary fluid and a low pressure stream of the secondary fluid. The secondary fluid circuit also has a primary-secondary heat exchanger permitting heat exchange between the high pressure stream of the primary fluid and the low pressure stream of the secondary fluid.Type: GrantFiled: August 14, 2020Date of Patent: October 17, 2023Assignee: BIOCOMPATIBLES UK LIMITEDInventors: Satish Ramadhyani, Graig Kveen, Harishankar Natesan
-
Patent number: 11759247Abstract: Various aspects of the present invention are directed towards apparatuses, systems, and method that may include a tissue ablation system. The tissue ablation system may include an ablation device, an ablation generator, and a controller configured to initiate a pre-ablation procedure in a medium, and during the pre-ablation procedure monitor temperature data and/or power data.Type: GrantFiled: March 12, 2021Date of Patent: September 19, 2023Assignee: BIOCOMPATIBLES UK LIMITEDInventors: Catherine Condie, Charles Houtz, Daniel Kollmann, Oleg Mosesov
-
Patent number: 11737824Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that may include a microwave ablation probe. The microwave ablation probe may include a feedline having an inner conductor, an outer conductor and a dielectric; and an antenna including a helical arm, the helical arm being electrically connected to the outer conductor of the feedline at a junction point, and a linear arm, the linear arm being electrically connected to the inner conductor of the feedline.Type: GrantFiled: August 7, 2020Date of Patent: August 29, 2023Assignee: BIOCOMPATIBLES UK LIMITEDInventors: Oleg F. Mosesov, Daniel T. Kollmann
-
Patent number: 11672876Abstract: This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead. The beads are prepared by activating pre-formed hydrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with chemotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.Type: GrantFiled: January 22, 2020Date of Patent: June 13, 2023Assignees: BIOCOMPATIBLES UK LIMITED, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICESInventors: Matthew R. Dreher, Bradford J. Wood, Ayele H. Negussie, Andrew Lennard Lewis, Yiqing Tang
-
Patent number: 11446074Abstract: A magnetic resonance imaging (MRI) guided surgical system is provided that includes one or more surgical tools having components configured to develop reactive effects when exposed to MR signals generated by the MRI system. The system includes a control system that can determine whether the MR system is generating MR signals, and if the control system determines that the MR system is generating MR signals, mitigates the reactive effects of MR signals on components of the surgical tools. The system can include a cryoablation system with a cryoprobe having a probe shaft being made of a metallic material. If the control system determines that the MR system is generating MR signals, the control system can electrically disconnect the cryoprobe and/or ignore electrical signals generated by the electric heater in response to exposure to MR signals, and/or initiate a cooling operation of the probe shaft, whereby the cooling operation.Type: GrantFiled: November 13, 2018Date of Patent: September 20, 2022Assignee: BIOCOMPATIBLES UK LIMITEDInventors: Daniel T. Kollmann, Timothy J. Davis, Satish Ramadhyani, Luan T. Chan
-
Patent number: 11040104Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-dil or 1,3-diol groups acetalized with radiopaque species.Type: GrantFiled: January 3, 2020Date of Patent: June 22, 2021Assignee: BIOCOMPATIBLES UK LTD.Inventors: Stephane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
-
Patent number: 10925979Abstract: This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres comprising the polymers. The microspheres are imageable during embolization procedures and can be loaded with drugs or other therapeutic agents to provide an imageable drug delivery system.Type: GrantFiled: January 3, 2020Date of Patent: February 23, 2021Assignee: BIOCOMPATIBLES UK LTD.Inventors: Stephane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
-
Patent number: 10568967Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-diol or 1,3-diol groups acetalised with radiopaque species.Type: GrantFiled: January 9, 2019Date of Patent: February 25, 2020Assignee: Biocompatibles UK Ltd.Inventors: Stéphane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
-
Patent number: 10556022Abstract: This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres comprising the polymers. The microspheres are imageable during embolization procedures and can be loaded with drugs or other therapeutic agents to provide an imageable drug delivery system.Type: GrantFiled: September 5, 2018Date of Patent: February 11, 2020Assignee: Biocompatibles UK Ltd.Inventors: Stéphane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
-
Patent number: 10525004Abstract: The present invention relates to composition comprising vesicles and associated with the vesicles, a chemical agent, for use in a method of treatment by therapy wherein the chemical agent is delivered trans- and/or intra-epithelially to a human or animal body, wherein the constructs comprise an amphiphilic block copolymer having a hydrophilic and a hydrophobic block. Methods for forming the composition are also provided.Type: GrantFiled: May 14, 2009Date of Patent: January 7, 2020Assignee: BIOCOMPATIBLES UK LIMITEDInventor: Giuseppe Battaglia
-
Patent number: 10406257Abstract: Pharmaceutical compositions comprising embolic particles, that optionally comprise pharmaceutical actives, in oil or emulsion formulations that are useful in therapeutic embolization procedures, particularly for the treatment of vascularised neoplasias, such as liver carcinomas.Type: GrantFiled: September 16, 2014Date of Patent: September 10, 2019Assignee: BIOCOMPATIBLES UK LTD.Inventors: Matthew R. Dreher, Andrew Lennard Lewis
-
Patent number: 10369343Abstract: An apparatus includes a fluid path, a coupling, and a nozzle. The fluid path is to carry a fluid including one or more microparticles. The coupling is located in the fluid path. The nozzle is located in the fluid path to move the fluid through a stagnant region located near the coupling.Type: GrantFiled: June 30, 2006Date of Patent: August 6, 2019Assignee: Biocompatibles UK LimitedInventors: Thomas J. Simpson, Jim Hagerman
-
Patent number: 10369344Abstract: An apparatus includes a fluid path, a coupling, and a nozzle. The fluid path is to carry a fluid including one or more microparticles. The coupling is located in the fluid path. The nozzle is located in the fluid path to move the fluid through a stagnant region located near the coupling. A method includes introducing a fluid including one or more microparticles into a fluid conduit including a coupling, aligning the fluid conduit near the coupling with a force field, and introducing the fluid includes delivering the one or more microparticles to a vasculature.Type: GrantFiled: July 5, 2012Date of Patent: August 6, 2019Assignee: Biocompatibles UK LimitedInventors: Thomas J. Simpson, Jim Hagerman
-
Patent number: 10350295Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-diol or 1,3-diol groups acetalized with radiopaque species.Type: GrantFiled: September 5, 2014Date of Patent: July 16, 2019Assignee: BIOCOMPATIBLES UK LTD.Inventors: Stéphane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
-
Patent number: 10307493Abstract: This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead. The beads are prepared by activating pre-formed hydrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with chemotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.Type: GrantFiled: March 14, 2014Date of Patent: June 4, 2019Assignees: Biocompatible UK Limited, National Institutes of HealthInventors: Matthew R. Dreher, Bradford J. Wood, Ayele H. Negussie, Andrew Leonard Lewis, Yiqing Tang
-
Publication number: 20190070332Abstract: The present invention provides emulsion compositions comprising an continuous oil phase, a discontinuous aqueous phase and a plurality of microparticles. The composition may comprise a pharmaceutical active ingredient located in the oil phase, the particulate phase or the aqueous phase. The emulsion compositions have improved stability and coherence and are useful in the treatment of tumours by embolotherapy.Type: ApplicationFiled: March 10, 2017Publication date: March 7, 2019Applicant: BIOCOMPATIBLES UK LIMITEDInventors: Matthew R. DREHER, Andrew Lennard LEWIS, Sean Leo WILLIS, Shui Ting CHUNG, Marcus Gordon CAINE
-
Patent number: 10098972Abstract: This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres comprising the polymers. The microspheres are imageable during embolization procedures and can be loaded with drugs or other therapeutic agents to provide an imageable drug delivery system.Type: GrantFiled: September 5, 2014Date of Patent: October 16, 2018Assignee: BIOCOMPATIBLES UK LTD.Inventors: Stéphane Hohn, Andrew Lennard Lewis
-
Publication number: 20180250230Abstract: New cationic polymers are provided that are suitable for the preparation of microspheres. The microspheres are capable of loading and eluting anionic species such as drugs and find use in i.a.Type: ApplicationFiled: September 5, 2016Publication date: September 6, 2018Applicant: BIOCOMPATIBLES UK LIMITEDInventors: Clare Louise HEAYSMAN, Andrew LLOYD, Gary James PHILLIPS, Andrew Lennard LEWIS
-
Patent number: RE47873Abstract: Embolic compositions comprising macromers having a backbone comprising a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure, such as polyvinyl alcohol, and pendant chains bearing crosslinkable groups and, optionally, other modifiers. When crosslinked, the macromers form hydrogels having many properties advantageous for use as embolic agents to block and fill lumens and spaces. The embolic compositions can be used as liquid embolic agents and crosslinked in situ or as preformed embolic articles, such as microspheres.Type: GrantFiled: March 16, 2015Date of Patent: February 25, 2020Assignee: BIOCOMPATIBLES UK LIMITEDInventors: Dennis W. Goupil, Hassan Chaouk, Troy Holland, Bruktawit T. Asfaw, Stephen D. Goodrich, Lucas Latini