Patents Assigned to Biocompatibles UK Limited
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Publication number: 20160258962Abstract: The present invention relates to a method of monitoring live cells, comprising the sequential steps of: (i) contacting the cells with self-assembled constructs associated with an imaging agent at t=0; (ii) incubating the cells for a period of time t1; (iii) imaging at least a sample of the live cells by means of the said imaging agent after time t1; wherein in step (i), at least some of the constructs are taken up into the cells; and wherein the constructs comprise an amphiphilic block copolymer having a hydrophilic and hydrophobic block.Type: ApplicationFiled: May 16, 2016Publication date: September 8, 2016Applicant: BIOCOMPATIBLES UK LIMITEDInventor: Giuseppe BATTAGLIA
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Publication number: 20160106673Abstract: The present invention provides a composition comprising vesicles and encapsulated within the vesicles, nucleic acid comprising less than 1000 nucleotides, wherein the vesicles comprise an amphiphilic block copolymer having a hydrophilic and a hydrophobic block. Methods of forming vesicles and methods of delivering nucleic acid, in particular, iRNA into cells, are also provided.Type: ApplicationFiled: December 28, 2015Publication date: April 21, 2016Applicant: BIOCOMPATIBLES UK LIMITEDInventors: Andrew Lennard LEWIS, Giuseppe BATTAGLIA, Irene CANTON, Peter William STRATFORD
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Publication number: 20160089389Abstract: A composition for chemoembolotherapy of solid tumours comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.Type: ApplicationFiled: December 8, 2015Publication date: March 31, 2016Applicant: BIOCOMPATIBLES UK LIMITEDInventors: Andrew Lennard LEWIS, Peter William STRATFORD, Simon LEPPARD, Pedro GARCIA, Brenda HALL, Maria Victoria Fajardo GONZALEZ
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Publication number: 20160089445Abstract: The present disclosure relates to a new polymerisation process in which ethylenically unsaturated monomers are polymerised by a living radical polymerisation process in the presence of an initiator and a catalyst. Polymers produced by this new process are also thought to be novel and may be used to derivatise biological molecules to improve their efficacy as therapeutic treatments. A preferred polymer is of formula The polymers are particularly suitable for derivatising proteins, such as interferon-?.Type: ApplicationFiled: August 6, 2015Publication date: March 31, 2016Applicant: BIOCOMPATIBLES UK LIMITEDInventors: Stephen James BROCCHINI, Antony Robert GODWIN, Yiqing TANG, Andrew Lennard LEWIS
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Patent number: 9254258Abstract: The present invention provides a composition comprising vesicles and encapsulated within the vesicles, nucleic acid comprising less than 1000 nucleotides, wherein the vesicles comprise an amphiphilic block copolymer having a hydrophilic and a hydrophobic block. Methods of forming vesicles and methods of delivering nucleic acid, in particular, iRNA into cells, are also provided.Type: GrantFiled: May 14, 2009Date of Patent: February 9, 2016Assignee: BIOCOMPATIBLES UK LIMITEDInventors: Andrew Lennard Lewis, Giuseppe Battaglia, Irene Canton, Peter William Stratford
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Patent number: 9241895Abstract: A composition for chemoembolotherapy of solid tumors comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.Type: GrantFiled: April 30, 2013Date of Patent: January 26, 2016Assignee: BIOCOMPATIBLES UK LIMITEDInventors: Andrew Lennard Lewis, Peter William Stratford, Simon Leppard, Pedro Garcia, Brenda Hall, Maria Victoria Fajardo Gonzalez
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Publication number: 20150328160Abstract: A pharmaceutical product comprising lyophilised polymer matrix including a biologically active compound, of particular utility for embolisation, having improved rehydration properties is packaged in an airtight package under vacuum.Type: ApplicationFiled: July 21, 2015Publication date: November 19, 2015Applicant: BIOCOMPATIBLES UK LIMITEDInventors: Sean WILLIS, Rosemary PALMER
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Publication number: 20150320684Abstract: A pharmaceutical product comprising lyophilised polymer matrix including a biologically active compound, of particular utility for embolisation, having improved rehydration properties is packaged in an airtight package under vacuum.Type: ApplicationFiled: July 21, 2015Publication date: November 12, 2015Applicant: BIOCOMPATIBLES UK LIMITEDInventors: Sean WILLIS, Rosemary PALMER
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Patent number: 9109016Abstract: The present disclosure relates to a new polymerisation process in which ethylenically unsaturated monomers are polymerised by a living radical polymerisation process in the presence of an initiator and a catalyst. Polymers produced by this new process are also thought to be novel and may be used to derivatise biological molecules to improve their efficacy as therapeutic treatments. A preferred polymer is of formula The polymers are particularly suitable for derivatising proteins, such as interferon-?.Type: GrantFiled: September 26, 2013Date of Patent: August 18, 2015Assignee: BIOCOMPATIBLES UK LIMITEDInventors: Stephen James Brocchini, Antony Robert Godwin, Yiqing Tang, Andrew Lennard Lewis
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Patent number: 9107833Abstract: A pharmaceutical product comprising lyophilized polymer matrix including a biologically active compound, of particular utility for embolization, having improved rehydration properties is packaged in an airtight package under vacuum.Type: GrantFiled: June 22, 2007Date of Patent: August 18, 2015Assignee: BIOCOMPATIBLES UK LIMITEDInventors: Sean Willis, Rosemary Palmer
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Publication number: 20140162969Abstract: There is provided a new use of microspheres comprising a water-insoluble, water-swellable polymer which is anionically charged at pH7, and electrostatically associated with the polymer, in releasable form, a cationically charged chemotherapeutic agent, in the manufacture of a composition for use in the treatment of a brain tumour, wherein in the treatment the composition is introduced into the brain and the chemotherapeutic agent is released from the microspheres, wherein the microspheres, when equilibrated in water at 37° C., comprise at least 40 wt % water based on weight of polymer plus water. Compositions comprising the microspheres and methods for the treatment of brain tumours are also provided.Type: ApplicationFiled: February 14, 2014Publication date: June 12, 2014Applicant: BIOCOMPATIBLES UK LIMITEDInventors: Andrew Lennard LEWIS, Yiqing TANG, Peter William STRATFORD
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Patent number: 8691791Abstract: There is provided a new use of microspheres comprising a water-insoluble, water-swellable polymer which is anionically charged at pH7, and electrostatically associated with the polymer, in releasable form, a cationically charged chemotherapeutic agent, in the manufacture of a composition for use in the treatment of a brain tumor, wherein in the treatment the composition is introduced into the brain and the chemotherapeutic agent is released from the microspheres, wherein the microspheres, when equilibrated in water at 37° C., comprise at least 40 wt % water based on weight of polymer plus water. Compositions comprising the microspheres and methods for the treatment of brain tumors are also provided.Type: GrantFiled: October 10, 2007Date of Patent: April 8, 2014Assignee: Biocompatibles UK LimitedInventors: Andrew Lennard Lewis, Yiqing Tang, Peter William Stratford
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Publication number: 20140030210Abstract: The present disclosure relates to a new polymerisation process in which ethylenically unsaturated monomers are polymerised by a living radical polymerisation process in the presence of an initiator and a catalyst. Polymers produced by this new process are also thought to be novel and may be used to derivatise biological molecules to improve their efficacy as therapeutic treatments. A preferred polymer is of formula The polymers are particularly suitable for derivatising proteins, such as interferon-?.Type: ApplicationFiled: September 26, 2013Publication date: January 30, 2014Applicant: BIOCOMPATIBLES UK LIMITEDInventors: Stephen James BROCCHINI, Antony Robert GODWIN, Yiqing TANG, Andrew Lennard LEWIS
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Publication number: 20140030350Abstract: The present invention relates to microparticles comprising a gel body, wherein the gel body comprises a synthetic polymer and a drug, wherein the microparticles have an average diameter in the range 40 to 1500 ?m, wherein the polymer is cross-linked by groups comprising disulfide linkages and is in the form of a hydrogel.Type: ApplicationFiled: January 27, 2012Publication date: January 30, 2014Applicant: BIOCOMPATIBLES UK LIMITEDInventors: Koorosh Ashrafi, Andrew Lennard Lewis, Clare Heaysman, Andrew Lloyd, Gary Philips
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Patent number: 8586098Abstract: A process is described for loading hydrophilic polymer particles with a water-insoluble solvent-soluble drug. The particles are preferably embolic agents. The method provides particles having little or no drug at the surface and in a surface layer, whereby the burst effect is minimised. The drug is precipitated in the core of the particle, leading to extended release. The drug is, for instance, paclitaxel, rapamycin, dexamethasone or ibuprofen.Type: GrantFiled: June 15, 2011Date of Patent: November 19, 2013Assignee: Biocompatibles UK LimitedInventors: Andrew Lennard Lewis, Yiqing Tang, Maria Victoria Gonzalez Fajardo
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Patent number: 8575397Abstract: The present disclosure relates to a new polymerization process in which ethylenically unsaturated monomers are polymerised by a living radical polymerization process in the presence of an initiator and a catalyst. Polymers produced by this new process are also thought to be novel and may be used to derivatise biological molecules to improve their efficacy as therapeutic treatments. A preferred polymer is of formula The polymers are particularly suitable for derivatising proteins, such as interferon-?.Type: GrantFiled: February 12, 2008Date of Patent: November 5, 2013Assignee: Biocompatibles UK LimitedInventors: Stephen James Brocchini, Antony Robert Godwin, Yiqing Tang, Andrew Lennard Lewis
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Publication number: 20130243695Abstract: A composition for chemoembolotherapy of solid tumours comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.Type: ApplicationFiled: April 30, 2013Publication date: September 19, 2013Applicant: BIOCOMPATIBLES UK LIMITEDInventors: Andrew Lennard LEWIS, Peter William STRATFORD, Simon LEPPARD, Pedro GARCIA, Brenda HALL, Maria Victoria Fajardo GONZALEZ
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Patent number: 8455003Abstract: A composition for chemoembolotherapy of solid tumors comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.Type: GrantFiled: April 20, 2012Date of Patent: June 4, 2013Assignee: Biocompatibles UK LimitedInventors: Andrew Lennard Lewis, Peter William Stratford, Simon Leppard, Pedro Garcia, Brenda Hall, Maria Victoria Fajardo Gonzalez
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Patent number: 8445612Abstract: An initiator for the terminal group of the polymer product of an atom or group radical transfer polymerisation has an activated carboxyl or an amine group which is reacted with an amine or carboxyl (respectively) group containing biologically active compound. The initiator is preferably 4-(3-(2-bromo, 2-methyl-propionate)phenyl)-propionic acid N-hydroxysuccinimide ester or 2-bromo, 2-methyl-propionic acid N-hydroxysuccinimide ester. The monomers preferably comprise a zwitterionic monomer such as 2-methacryloxyethyl-2?-trimethyl ammoniumethyl phosphate inner salt.Type: GrantFiled: September 23, 2011Date of Patent: May 21, 2013Assignee: Biocompatibles UK LimitedInventors: Andrew Lennard Lewis, Simon William Leppard
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Patent number: 8431113Abstract: The present invention relates to conjugates of biologically active compounds, preferably therapeutically active compounds, with polymeric moieties having low polydispersity, as well as controlled polymerisation processes for producing the conjugates. An initiation for a controlled radical polymerisation process comprises a biologically active, usually therapeutically active, moiety and the monomer includes zwitterionic monomer for instance 2-methacryloyloxyethyl-2?-trimethylammonium ethyl phosphate inner salt. The process allows close control of the molecular weight and polydispersity of the polymeric moiety and the possibility of optimising the delivery characteristics of the active agent.Type: GrantFiled: September 23, 2011Date of Patent: April 30, 2013Assignee: Biocompatibles UK LimitedInventor: Andrew Lennard Lewis