Abstract: Compounds represented by the formula:
wherein A is selected from the group consisting of
W is NH2 or H; and each X, Y and Z is individually selected from the group consisting of OH, H and halogen provided at least one of X and Y is H; tautomers, or pharmaceutically acceptable salts thereof; are provided. Compounds of the present invention are useful as inhibitors of PNP and of T-cell proliferation. Compounds of the present invention are useful for treating Cancer. Method for preparing the compounds of the present invention are also provided.
Type:
Grant
Filed:
March 22, 2001
Date of Patent:
May 14, 2002
Assignee:
Biocryst Pharmacueticals, Inc.
Inventors:
Philip E. Morris, Jr., John A. Montgomery, Yarlagadda S. Babu