Patents Assigned to BioCure, Inc.
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Patent number: 9232805Abstract: A composition comprising a macromer that can be in situ polymerized into a hydrogel wound dressing directly on a wound and one or more antimicrobial agents intended to achieve bacteriostasis and/or be bacteriocidal. The antimicrobial agent is released upon application and trapped in the hydrogel upon its formation and also released over a period of time into the wound.Type: GrantFiled: June 28, 2011Date of Patent: January 12, 2016Assignee: BIOCURE, INC.Inventors: Bruktawit T. Asfaw, John C. Jackson, Zhihua Lu, Xiaowen Zhai, Sameer Shums, Thomas Hirt, Xianbo Hu, Claude-Raymond René
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Patent number: 8221735Abstract: Embolic compositions comprising macromers having a backbone comprising a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure, such as polyvinyl alcohol, and pendant chains bearing crosslinkable groups and, optionally, other modifiers. When crosslinked, the macromers form hydrogels having many properties advantageous for use as embolic agents to block and fill lumens and spaces. The embolic compositions can be used as liquid embolic agents and crosslinked in situ or as preformed embolic articles, such as microspheres.Type: GrantFiled: April 23, 2009Date of Patent: July 17, 2012Assignee: BioCure, Inc.Inventors: Dennis W. Goupil, Hassan Chaouk, Troy Holland, Bruktawit T. Asfaw, Stephen D. Goodrich, Lucas Latini
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Patent number: 7070809Abstract: Hydrogel biomedical articles formed from macromers having a polymeric backbone comprising 1,2-diol and/or 1,3-diol units, such as polyvinyl alcohol, and pendant chains bearing crosslinkable groups and, optionally, other modifiers.Type: GrantFiled: March 13, 2001Date of Patent: July 4, 2006Assignee: BioCure, Inc.Inventors: Dennis W. Goupil, Hassan Chaouk, Troy Holland, Bruktawit T. Asfaw, Stephen D. Goodrich, Lucas Latini
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Patent number: 6916488Abstract: Vesicles made from amphiphilic copolymers are disclosed. The amphiphilic copolymers can be ABA copolymers, where one of A and B is hydrophilic and the other is hydrophobic. AB copolymers can also be used. The copolymers may be crosslinked to form nanocapsules. Crosslinking can be accomplished using a variety of methods, including end to end polymerization of copolymers having terminal unsaturated groups. Molecules, such as membrane proteins, can be incorporated into the wall of the vesicles or nanocapsules.Type: GrantFiled: July 13, 2000Date of Patent: July 12, 2005Assignee: BioCure, Inc.Inventors: Wolfgang Meier, Thomas Hirt, Corinne Nardin
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Publication number: 20050129656Abstract: Compositions comprising macromers having a backbone comprising units having a 1,2-diol and/or 1,3-diol structure for tissue bulking and coating. Such polymers include poly(vinyl alcohol) (PVA) and hydrolyzed copolymers of vinyl acetate, for example, copolymers with vinyl chloride, N-vinylpyrrolidone, etc. The backbone polymer contains pendant chains bearing crosslinkable groups and, optionally, other modifiers. When crosslinked, the macromers form hydrogels having many properties advantageous for use as agents to hulk and coat tissues.Type: ApplicationFiled: January 13, 2005Publication date: June 16, 2005Applicant: BioCure, Inc.Inventors: Dennis Goupil, Hassan Chaouk, Troy Holland, Bruktawit Asfaw, Stepehen Goodrich, Lucas Latini
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Patent number: 6723814Abstract: Membranes made from amphiphilic copolymers are disclosed. The amphiphilic copolymers can be ABA copolymers, where one of A and B is hydrophilic and the other is hydrophobic. The copolymers may be crosslinked to form more stable structures. Crosslinking can be accomplished using a variety of methods, including end to end polymerization of copolymers having terminal unsaturated groups. Molecules such as membrane proteins can be incorporated into the membrane to allow the transport there through of selected components.Type: GrantFiled: May 16, 2001Date of Patent: April 20, 2004Assignee: BioCure, Inc.Inventors: Wolfgang Meier, Corinne Nardin, Mathias Winterhalter
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Patent number: 6676971Abstract: Embolic compositions comprising macromers having a backbone comprising a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure, such as polyvinyl alcohol, and pendant chains bearing crosslinkable groups and, optionally, other modifiers. When crosslinked, the macromers form hydrogels having many properties advantageous for use as embolic agents to block and fill lumens and spaces. The embolic compositions can be used as liquid embolic agents and crosslinked in situ or as preformed embolic articles, such as microspheres.Type: GrantFiled: March 13, 2001Date of Patent: January 13, 2004Assignee: BioCure, Inc.Inventors: Dennis W. Goupil, Hassan Chaouk, Troy Holland, Bruktawit T. Asfaw, Stephen D. Goodrich, Lucas Latini
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Patent number: 6652883Abstract: Compositions comprising macromers having a backbone comprising units having a 1,2-diol and/or 1,3-diol structure for tissue bulking and coating. Such polymers include poly(vinyl alcohol) (PVA) and hydrolyzed copolymers of vinyl acetate, for example, copolymers with vinyl chloride, N-vinylpyrrolidone, etc. The backbone polymer contains pendant chains bearing crosslinkable groups and, optionally, other modifiers. When crosslinked, the macromers form hydrogels having many properties advantageous for use as agents to bulk and coat tissues.Type: GrantFiled: March 13, 2001Date of Patent: November 25, 2003Assignee: BioCure, Inc.Inventors: Dennis W. Goupil, Hassan Chaouk, Troy Holland, Bruktawit T. Asfaw, Stephen D. Goodrich, Lucas Latini
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Patent number: 6616946Abstract: Polymeric hollow particles for delivery of an agent are provided that change permeability in response to a change in an external stimulus such as pH, temperature, light, ionic strength, electric field, magnetic field and/or solvent composition. The particles can have a shell formed of an amphiphilic triblock ABA or BAB copolymer, where A is a hydrophilic block and B is a hydrophobic block. Low permeability particles with a reversibly permeable shell expand and increase permeability in response to a stimulus so that an active agent such as a therapeutic, prophylactic or diagnostic agent can be introduced. Removing the stimulus allows the particles to return to a low permeability state to form particles loaded with the active agent. Surfaces of the particles can be modified with specific ligands that allow the particles to be directed to a specific target via molecular recognition.Type: GrantFiled: November 15, 2000Date of Patent: September 9, 2003Assignee: BioCure, Inc.Inventors: Wolfgang Meier, Marc Sauer
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Patent number: RE47121Abstract: Embolic compositions comprising macromers having a backbone comprising a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure, such as polyvinyl alcohol, and pendant chains bearing crosslinkable groups and, optionally, other modifiers. When crosslinked, the macromers form hydrogels having many properties advantageous for use as embolic agents to block and fill lumens and spaces. The embolic compositions can be used as liquid embolic agents and crosslinked in situ or as preformed embolic articles, such as microspheres.Type: GrantFiled: July 17, 2014Date of Patent: November 13, 2018Assignee: BioCure, Inc.Inventors: Dennis W. Goupil, Hassan Chaouk, Troy Holland, Bruktawit T. Asfaw, Stephen D. Goodrich, Lucas Latini
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Patent number: RE48302Abstract: Embolic compositions comprising macromers having a backbone comprising a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure, such as polyvinyl alcohol, and pendant chains bearing crosslinkable groups and, optionally, other modifiers. When crosslinked, the macromers form hydrogels having many properties advantageous for use as embolic agents to block and fill lumens and spaces. The embolic compositions can be used as liquid embolic agents and crosslinked in situ or as preformed embolic articles, such as microspheres.Type: GrantFiled: July 26, 2018Date of Patent: November 10, 2020Assignee: BioCure, Inc.Inventors: Dennis Goupil, Hassan Chaouk, Troy Holland, Bruktawit Asfaw, Stephen D. Goodrich, Lucas Latini