Abstract: A complex of Ag, Zn, Cu, Pt, Au, oxides, hydroxides and salts thereof; with a cyclodextrin of formula (I). Advantageously, the complex further includes an organic therapeutic agent, preferably an antibiotic agent. The complexation advantageously maintains the metal: organic therapeutic agent molar ratio. Even more advantageously, the complexation enhances the intrinsic aqueous solubility of the metal-organic therapeutic agent association. Also, compositions, pharmaceutical compositions and adequate formulations and uses thereof as well as devices including a complex of the invention. Lastly, a method for improving the aqueous solubility of a metal selected from Ag, Zn, Cu, Pt, Au, Ru, As, Sb, Bi, Ti, V, Ni, Hg, Pb, Co, oxides, hydroxides and salts thereof by providing a reaction mixture including the metal, an aqueous medium and a cyclodextrin of formula (I).
Abstract: A composition for protecting and/or preserving cells, tissues or organs, includes at least one cyclodextrin, preferably closely combined with an antioxidant. A process for producing this composition and its uses are also disclosed.
Type:
Grant
Filed:
December 12, 2007
Date of Patent:
September 13, 2011
Assignees:
Biocydex, Universite de Poitiers, Centre Hospitalier Universitaire de Poitiers, Institut National Sante Recherche Medicale
Inventors:
Yves Cenatiempo, El Mustapha Belgsir, Manilduth Ramnath, Frédéric Favreau, Michel Carretier, Gérard Mauco, Thierry Hauet
Abstract: A process for the preparation of cyclodextrin oligomers or polymers, whereby the cyclodextrin molecules are coupled to one another covalently via a spacer arm, based on a coupling reaction between an alkyne and an azide producing the formation of an aromatic heterocyclic bridge between the coupled units. Also described are the cyclodextrin oligomers or polymers that are obtained and their uses.
Type:
Application
Filed:
October 18, 2007
Publication date:
December 2, 2010
Applicant:
BIOCYDEX
Inventors:
Frederic Turpin, Carole Brigand, Yves Cenatiempo, EI Mustapha Belgsir
Abstract: The present invention relates to a reaction medium for identifying/detecting microorganisms, that comprises at least one active molecule encapsulated in a cyclodextrin.
Type:
Application
Filed:
April 28, 2008
Publication date:
May 13, 2010
Applicants:
Biomerieux, Biocydex
Inventors:
El Mustapha Belgsir, Yves Cenatiempo, Manilduth Ramnath, Denis Robichon
Abstract: The object of the invention is a composition for protecting and/or preserving cells, tissues or organs, characterized in that it comprises at least one cyclodextrin, preferably closely combined with an antioxidant. The invention also relates to a process for producing this composition and its uses.
Type:
Application
Filed:
December 12, 2007
Publication date:
May 14, 2009
Applicants:
BIOCYDEX, SOCIETE PAR ACTIONS SIMPLIFIEE, UNIVERSITE DE POITIERS, ETABLISSEMENT PUBLIC, CENTRE HOSPITALIER UNIVERSITAIRE DE POITIERS, ETABLISSEMENT D'HOSPITALISATION, INSTITUT NATIONAL SANTE RECHERCHE MEDICALE, ETABLISSEMENT PUBLIC
Inventors:
Yves CENATIEMPO, El Mustapha Belgsir, Manilduth Ramnath, Frederic Favreau, Michel Carretier, Gerard Mauco, Thierry Hauet