Patents Assigned to BioDelivery Sciences International, Inc.
-
Publication number: 20160310409Abstract: The present invention provides methods for enhancing transmucosal uptake of a medicament, e.g., fentanyl or buprenorphine, to a subject and related devices. The method includes administering to a subject a transmucosal drug delivery device comprising the medicament. Also provided are devices suitable for transmucosal administration of a medicament to a subject and methods of their administration and use. The devices include a medicament disposed in a mucoadhesive polymeric diffusion environment and a barrier environment.Type: ApplicationFiled: June 30, 2016Publication date: October 27, 2016Applicant: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Niraj Vasisht
-
Patent number: 8703177Abstract: The present invention provides abuse deterrent mucoadhesive devices for delivery of buprenorphine. Each device comprises a mucoadhesive layer and a backing layer, and the pH in each layer is selected, such that absorption of buprenorphine is maximized.Type: GrantFiled: August 20, 2012Date of Patent: April 22, 2014Assignee: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Niraj Vasisht
-
Patent number: 8642073Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.Type: GrantFiled: January 11, 2007Date of Patent: February 4, 2014Assignees: BioDelivery Sciences International, Inc., University of Medicine and Dentistry of New JerseyInventors: Raphael J. Mannino, Susan Gould-Fogerite, Sara L. Krause-Elsmore, David Delmarre, Ruying Lu
-
Patent number: 8546555Abstract: Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.Type: GrantFiled: November 17, 2011Date of Patent: October 1, 2013Assignee: Biodelivery Sciences International, Inc.Inventors: Susan Gould-Fogerite, Raphael J. Mannino, Patrick Ahl, Gaofeng Shang, Zi Wei Chen, Sara L. Krause-Elsmore
-
Publication number: 20120294901Abstract: A process for producing a small-sized, lipid-based cochleates. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca2+ or Zn2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing biologically relevant molecules.Type: ApplicationFiled: April 6, 2012Publication date: November 22, 2012Applicants: University of Medicine and Dentistry of New Jersey, BioDelivery Sciences International, Inc.Inventors: Leila Zarif, Tuo Jin, Ignacio Segarra, Raphael J. Mannino
-
Publication number: 20120282322Abstract: Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.Type: ApplicationFiled: November 17, 2011Publication date: November 8, 2012Applicant: BIODELIVERY SCIENCES INTERNATIONAL, INC.Inventors: Susan Gould-Fogerite, Raphael J. Mannino, Patrick Ahl, Gaofeng Shang, Zi Wei Chen, Sara L. Krause-Elsmore
-
Publication number: 20120232260Abstract: The present invention is directed to cochleate compositions that include a nucleotide that is associated with a positively charged amphiphile. The present invention also includes methods for making and using the compositions provided herein.Type: ApplicationFiled: February 9, 2012Publication date: September 13, 2012Applicant: BioDelivery Sciences International, Inc.Inventors: Ruying Lu, Raphael J. Mannino
-
Publication number: 20120231064Abstract: The present invention relates to a pharmaceutical delivery device for application of a pharmaceutical to mucosal surfaces. The device comprises an adhesive layer and a non-adhesive backing layer, and the pharmaceutical may be provided in either or both layers. Upon application, the device adheres to the mucosal surface, providing localized drug delivery and protection to the treatment site. The kinetics of erodability are easily adjusted by varying the number of layers and/or the components.Type: ApplicationFiled: October 10, 2011Publication date: September 13, 2012Applicant: BIODELIVERY SCIENCES INTERNATIONAL, INC.Inventors: Gilles H. Tapolsky, David W. Osborne
-
Publication number: 20120195932Abstract: The present invention provides geodate delivery vehicles and methods of manufacture and administration. A vehicle including a lipid monolayer disposed about a hydrophobic domain is disclosed, that can be part of an emulsion or other mixture, or further disposed in a lipid strata. A vehicle including a lipid strata disposed about a hydrophobic domain is also disclosed. The vehicle can be incorporated into a variety of medicinal, food preparations, and personal care products to deliver or stabilize a cargo moiety. Packaged delivery vehicles for to later addition of cargo moieties are also contemplated.Type: ApplicationFiled: January 25, 2010Publication date: August 2, 2012Applicant: BioDelivery Sciences International, Inc.Inventors: Raphael J. Mannino, Sara L. Krause-Elsmore, Susan Gould-Fogerite, David Delmarre, Ruying Lu
-
Publication number: 20120178793Abstract: The present invention is directed to cochleate composition that include a nucleotide. The nucleotide may generally be bound via a linker to a component of the cochleate, or to a lipophilic tail. Additionally or alternatively, the nucleotide may he associated with a transfection agent. The present invention also includes methods for making and using, the compositions provided herein.Type: ApplicationFiled: March 19, 2012Publication date: July 12, 2012Applicant: BioDelivery Sciences International, Inc.Inventors: Raphael J. Mannino, Susan Gould-Fogerite
-
Publication number: 20120164191Abstract: The present invention provides methods for enhancing transmucosal uptake of a medicament, e.g., fentanyl or buprenorphine, to a subject and related devices. The method includes administering to a subject a transmucosal drug delivery device comprising the medicament. Also provided are devices suitable for transmucosal administration of a medicament to a subject and methods of their administration and use. The devices include a medicament disposed in a mucoadhesive polymeric diffusion environment and a barrier environment.Type: ApplicationFiled: March 6, 2012Publication date: June 28, 2012Applicant: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Niraj Vasisht
-
Patent number: 8147866Abstract: The present invention provides methods for enhancing transmucosal uptake of a medicament, e.g., fentanyl or buprenorphine, to a subject and related devices. The method includes administering to a subject a transmucosal drug delivery device comprising the medicament. Also provided are devices suitable for transmucosal administration of a medicament to a subject and methods of their administration and use. The devices include a medicament disposed in a mucoadhesive polymeric diffusion environment and a barrier environment.Type: GrantFiled: July 15, 2011Date of Patent: April 3, 2012Assignee: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Niraj Vasisht
-
Publication number: 20120027839Abstract: The present invention relates to a pharmaceutical delivery device for application of a pharmaceutical to mucosal surfaces. The device comprises an adhesive layer and a non-adhesive backing layer, and the pharmaceutical may be provided in either or both layers. Upon application, the device adheres to the mucosal surface, providing localized drug delivery and protection to the treatment site. The kinetics of erodability are easily adjusted by varying the number of layers and/or the components.Type: ApplicationFiled: February 24, 2011Publication date: February 2, 2012Applicant: BIODELIVERY SCIENCES INTERNATIONAL, INC.Inventors: Gilles H. Tapolsky, David W. Osborne
-
Publication number: 20110262522Abstract: The present invention provides methods for enhancing transmucosal uptake of a medicament, e.g., fentanyl or buprenorphine, to a subject and related devices. The method includes administering to a subject a transmucosal drug delivery device comprising the medicament. Also provided are devices suitable for transmucosal administration of a medicament to a subject and methods of their administration and use. The devices include a medicament disposed in a mucoadhesive polymeric diffusion environment and a barrier environment.Type: ApplicationFiled: July 15, 2011Publication date: October 27, 2011Applicant: BioDelivery Sciences International, Inc.Inventors: Andrew Finn, Niraj Vasisht
-
Publication number: 20110189259Abstract: The present invention relates to a pharmaceutical dosage form for transmucosal delivery of an active agent to two or more mucosal surfaces. The dosage form is presented as a transmucosal delivery device. The devices of the invention may include at least two mucoadhesive surfaces. The devices may further include an intermediate layer disposed between the mucoadhesive layers. The pharmaceutical can be incorporated in any one or all of the mucoadhesive layers or the intermediate layer. Upon application, the device adheres to at least two surfaces, providing transmucosal delivery of the drug to at least two surfaces.Type: ApplicationFiled: June 23, 2009Publication date: August 4, 2011Applicant: BIODELIVERY SCIENCES INTERNATIONAL, INC.Inventors: Niraj Vasisht, Andrew Finn
-
Publication number: 20110091523Abstract: Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.Type: ApplicationFiled: February 11, 2010Publication date: April 21, 2011Applicant: BioDelivery Sciences International, Inc.Inventors: Susan Gould-Fogerite, Raphael J. Mannino, Patrick Ahl, Gaofeng Shang, Zi Wei Chen, Sara L. Krause-Elsmore
-
Publication number: 20100178325Abstract: The present invention is directed to cochleate compositions that include a nucleotide that is associated with a positively charged amphiphile. The present invention also includes methods for making and using the compositions provided herein.Type: ApplicationFiled: August 22, 2007Publication date: July 15, 2010Applicant: BioDelivery Sciences International, Inc.Inventor: Ruying LU
-
Publication number: 20090028904Abstract: A process for producing a small-sized, lipid-based cochleate. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca2+ or Zn2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing biologically relevant molecules.Type: ApplicationFiled: April 23, 2008Publication date: January 29, 2009Applicant: BioDelivery Sciences International, Inc.Inventors: Leila Zarif, Tuo Jin, Ignacio Segarra, Raphael J. Mannino
-
Publication number: 20080242625Abstract: The present invention is directed to cochleate composition that include a nucleotide. The nucleotide may generally be bound via a linker to a component of the cochleate, or to a lipophilic tail. Additionally or alternatively, the nucleotide may be associated with a transfection agent. The present invention also includes methods for making and using the compositions provided herein.Type: ApplicationFiled: April 11, 2005Publication date: October 2, 2008Applicant: BioDelivery Sciences International, Inc.Inventors: Raphael J. Mannino, Susan Gould-Fogerite
-
Publication number: 20080009457Abstract: Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.Type: ApplicationFiled: January 11, 2007Publication date: January 10, 2008Applicant: BioDelivery Sciences International, Inc.Inventors: Susan Gould-Fogerite, Raphael Mannino, Patrick Ahl, Gaofeng Shang, Zi Chen, Sara Krause-Elsmore