Patents Assigned to BIODESY, LLC
  • Method Using A Nonlinear Optical Technique for Detection of Interactions Involving A Conformational Change
    Publication number: 20140187431
    Abstract: A nonlinear optical technique, such as second or third harmonic or sum or difference frequency generation, is used to detect binding interactions, or the degree or extent of binding, that comprise conformational change. In one aspect of the present invention, the nonlinear optical technique detects a conformational change in a probe due to target binding. In another aspect of the invention, the nonlinear optical technique screens candidate probes by detecting a conformational change due to a probe-target interaction. In another aspect of the invention, the nonlinear optical technique screens candidate modulators of a probe-target interaction by detecting a conformational change in the presence of the modulator.
    Type: Application
    Filed: March 15, 2013
    Publication date: July 3, 2014
    Applicant: BIODESY, LLC
    Inventor: BIODESY, LLC
  • Method Using A Nonlinear Optical Technique for Detection of Interactions Involving A Conformational Change
    Publication number: 20140186854
    Abstract: A nonlinear optical technique, such as second or third harmonic or sum or difference frequency generation, is used to detect binding interactions, or the degree or extent of binding, that comprise conformational change. In one aspect of the present invention, the nonlinear optical technique detects a conformational change in a probe due to target binding. In another aspect of the invention, the nonlinear optical technique screens candidate probes by detecting a conformational change due to a probe-target interaction. In another aspect of the invention, the nonlinear optical technique screens candidate modulators of a probe-target interaction by detecting a conformational change in the presence of the modulator.
    Type: Application
    Filed: March 15, 2013
    Publication date: July 3, 2014
    Applicant: BIODESY, LLC
    Inventor: Joshua S. Salafsky
  • METHOD USING A NONLINEAR OPTICAL TECHNIQUE FOR DETECTION OF INTERACTIONS INVOLVING A CONFORMATIONAL CHANGE
    Publication number: 20100120164
    Abstract: A nonlinear optical technique, such as second or third harmonic or sum or difference frequency generation, is used to detect binding interactions, or the degree or extent of binding, that comprise conformational change. In one aspect of the present invention, the nonlinear optical technique detects a conformational change in a probe due to target binding. In another aspect of the invention, the nonlinear optical technique screens candidate probes by detecting a conformational change due to a probe-target interaction. In another aspect of the invention, the nonlinear optical technique screens candidate modulators of a probe-target interaction by detecting a conformational change in the presence of the modulator.
    Type: Application
    Filed: September 30, 2009
    Publication date: May 13, 2010
    Applicant: BIODESY, LLC
    Inventor: Joshua S. Salafsky