Patents Assigned to Bioferma Murcia S.A.
  • Process for preparing cephalosporanic acid derivatives using a-ketoacid derivatives
    Publication number: 20040181056
    Abstract: A process for preparing cephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C compound of formula III:— 1
    Type: Application
    Filed: March 19, 2004
    Publication date: September 16, 2004
    Applicant: Bioferma Murcia S.A.
    Inventors: Alvaro Sanchez-Ferrer, Jose Aniceto Lopez-Mas, Francisco Garcia-Carmona
  • Process for preparing cephalosporanic acid derivatives using alpha-ketoacid derivatives
    Publication number: 20040175783
    Abstract: A process for preparing cephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C compound of formula III:— 1
    Type: Application
    Filed: March 19, 2004
    Publication date: September 9, 2004
    Applicant: Bioferma Murcia S.A.
    Inventors: Alvaro Sanchez-Ferrer, Jose Aniceto Lopez-Mas, Francisco Garcia-Carmona
  • Process for preparing cephalosporanic acid derivatives using &bgr;-ketoacid derivatives
    Patent number: 6730497
    Abstract: A process for preparing cephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C compound of formula III: into a 3-thiolated-&agr;-ketoadipyl-7-aminocephalosporanic acid derivative of formula IV: wherein R is a heterocyclic group comprising at least a nitrogen atom. Compounds of formula IV are used in the preparation of cephalosporin C antibiotics and derivatives thereof.
    Type: Grant
    Filed: April 19, 2002
    Date of Patent: May 4, 2004
    Assignee: Bioferma Murcia S.A.
    Inventors: Alvaro Sánchez-Ferrer, José Aniceto López-Más, Francisco García-Carmona
  • Process for preparing cephalosporin derivatives
    Publication number: 20040067549
    Abstract: An enzymatic process for preparing 3-thiolated 7-aminocephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C of the formula I: 1
    Type: Application
    Filed: September 25, 2003
    Publication date: April 8, 2004
    Applicant: Bioferma Murcia S.A.
    Inventors: Alvaro Sanchez-Ferrer, Jose Aniceto Lopez-Mas, Francisco Garcia-Carmona
  • Process for preparing cephalosporin derivatives
    Patent number: 6642020
    Abstract: An enzymatic process for preparing 3-thiolated 7-aminocephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C of the formula I: to form a 3-thiolated-glutaryl-7-ACA of the formula II and enzymatically converting a compound of formula II to form a 3-thiolated-7-ACA of the formula III wherein R is a heterocyclic group comprising at least one nitrogen atom and R1 and R2 are both hydrogen atoms or one of them is a hydrogen atom and the other is an acyl donor.
    Type: Grant
    Filed: April 19, 2002
    Date of Patent: November 4, 2003
    Assignee: Bioferma Murcia S.A.
    Inventors: Álvaro Sánchez-Ferrer, José Aniceto López-Más, Francisco Garcia-Carmona