Patents Assigned to Bioflexin AB
  • Patent number: 6183994
    Abstract: Synthesis of an amino-disaccharide, amino-oligosaccharide or a derivative thereof, characterized in that a monosaccharide, a disaccharide, an oligosaccharide, a glycoside or a derivative thereof, in the presence of a glycosidase as catalyst, is reacted with an amino-deoxy-saccharide or a glycoside or derivative thereof, and that the amino-saccharide is optionally isolated from the product mixture directly or after chemical/enzymatic modification.
    Type: Grant
    Filed: May 25, 1999
    Date of Patent: February 6, 2001
    Assignee: Bioflexin AB
    Inventor: Kurt G. I. Nilsson
  • Patent number: 6077695
    Abstract: Disclosed is a method of producing a compound which contains the Glc.beta.1-4GlcN structure involving reacting at least one donor substance Glc.beta.OR where R is an organic group, and at least one acceptor substance which is a glucopyranosamino derivative having the formula GlcNR"-R'", wherein NR" is an azido, 2-N-acetyl-, 2-N-phtalimido, or an organic group bound to the 2-N-group of glucosamine, wherein R'" is a glycosidically bound fluoro or is an O-, C-, N- or S-glycosidically bound aliphatic or aromatic compound, with the optional proviso that if NR" is NHAc then R'" is not OH and if NR" is not NHAc then R'" may be OH, in the presence of Bullera singularis or an E.C. group 3.2 glycosidase of essentially the same structure as an E.C. group 3.2 glucosidase obtained from Bullera singularis to form the Glc.beta.1-4GlcN derivative; and optionally isolating the compound which contains the Glc.beta.1-4GlcN structure.
    Type: Grant
    Filed: June 16, 1998
    Date of Patent: June 20, 2000
    Assignee: Bioflexin AB
    Inventor: Kurt G. I. Nilsson
  • Patent number: 5936075
    Abstract: Synthesis of an amino-disaccharide, amino-oligosaccharide or a derivative thereof, characterized in that a monosaccharide, a disaccharide, an oligosaccharide, a glycoside or a derivative thereof, in the presence of a glycosidase as catalyst, is reacted with an amino-deoxy-saccharide or a derivative thereof, and that the amino-saccharide is isolated from the product mixture directly or after chemical/enzymatic modification.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 10, 1999
    Assignee: Bioflexin AB
    Inventor: Kurt G. I. Nilsson
  • Patent number: 5882902
    Abstract: Method for synthesis of GalNAc.alpha.-serine or GalNAc.alpha.-threonine containing compounds, including at least one reaction where an .alpha.-saccharide or .alpha.-glycoside of GalNAca is used as gylcosyl donor and a derivative of serine of threonine is used as acceptor in a transglycosylation reaction with N-acetyl-.alpha.-D-galactosaminidase as the catalyst, wherein said acceptor has been modified in its N-terminal .alpha.-amino group and optionally in its c-terminal carboxyl group.
    Type: Grant
    Filed: May 12, 1997
    Date of Patent: March 16, 1999
    Assignee: Bioflexin AB
    Inventor: Kurt Nilsson
  • Patent number: 5856143
    Abstract: Synthesis of an amino-disaccharide, amino-oligosaccharide or a derivative thereof, characterized in that a monosaccharide, a disaccharide, an oligosaccharide, a glycoside or a derivative thereof, in the presence of a glycosidase as catalyst, is reacted with an amino-deoxy-saccharide or a derivative thereof, and that the amino-saccharide is isolated from the product mixture directly or after chemical/enzymatic modification.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 5, 1999
    Assignee: Bioflexin AB
    Inventor: Kurt G. I. Nilsson