Abstract: The presently disclosed subject matter provides dual-depth thermoplastic microfluidic devices, related kits, microfluidic systems comprising the dual-depth thermoplastic microfluidic device, methods of isolating nucleic acid analytes from a liquid sample, and methods of isolating extracellular vesicles from a liquid sample.
Abstract: This invention provides methods and compositions for capturing circulating tumor cells (CTCs) as well as various divergent CTC phenotypes using seprase-specific affinity reagents. Methods of analyzing CTCs and assessing their metastatic potential in vivo and in vitro are also disclosed.
Type:
Application
Filed:
November 8, 2013
Publication date:
May 15, 2014
Applicants:
ROCHE MOLECULAR SYSTEMS, INC., THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, BIOFLUIDICA, INC
Inventors:
George Martin, Steven Soper, Makgorzata Witek, Jen Jen Yeh