Patents Assigned to Biofusion, Inc.
  • Patent number: 4578167
    Abstract: Apparatus for fusing cells by applying an alternating voltage across a pair of spaced-apart elongated electrodes. The electrodes form between themselves an elongated fusion chamber for receiving a suspension of cells to be fused. The electrodes have a cross-sectional shape adapted to produce an inhomogenous electric field within the fusion chamber suitable for inducing dielectrophoretic movement of suspended cells towards the electrodes and for maintaining strings or lines of two or more cells in contact with the electrodes along an elongated, narrow attachment zone on each electrode. A voltage pulse is applied across the electrodes after the cells have become attached thereto. The duration and amplitude of the pulse is selected to be sufficient to cause the strings of cells to fuse into a single cell.
    Type: Grant
    Filed: September 28, 1982
    Date of Patent: March 25, 1986
    Assignee: Biofusion, Inc.
    Inventor: Wolfgang Schoner